The relationship between beta-2-microglobulin, CD4 lymphocyte count, AIDS and death in HIV-positive individuals

Epidemiology and Infection

Volumn 118, Issue 3, 1997, Pages 259-266

  Mocroft, A ^a   Johnson, M A ^a   Sabin, C A ^a   Bofill, M ^a   Janossy, G ^a   Phillips, A N ^a  

^a ROYAL FREE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 MICROGLOBULIN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; ARTICLE; CONTROLLED STUDY; DEATH; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; NONBIOLOGICAL MODEL; PROGNOSIS; RISK ASSESSMENT; TIME;

EID: 0030789990     PISSN: 09502688     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0950268897007437     Document Type: Article

References (33)

1. Cooper EH, Forbes MA, Hambling MH. Serum beta-2-microglobulin and C-reactive protein concentrations in viral infections. J Clin Pathol 1984; 37: 1140-3.
2. Moss AR, Bachetti P, Osmond D, et al. Seropositivity for HIV and the development of AIDS or AIDS related condition: three year follow-up of the San Francisco General Hospital Cohort. BMJ 1988; 296: 745-50.
3. Lane HC, Masur H, Gelmann EP, et al. Correlation between immunological function and clinical sub-populations of patients with the acquired immunodeficiency syndrome. Am J Med 1985; 78: 417-22.
4. Phillips AN, Lee CA, Elford J, et al. Serial CD4 lymphocyte counts and development of AIDS. Lancet 1991; 337: 389-92.
5. Fahey JL, Taylor JMG, Detels R, et al. The prognostic vale of cellular and serological markers in infection with human immunodeficiency virus type-1. N Engl J Med 1990; 322: 168-72.
6. Schwartlander B, Bek B, Skarabis H, et al. Improvement of the predictive value of CD4+ lymphocyte count by beta-2-microglobulin, immunoglobulin A and erythrocyte sedimentation rate. AIDS 1993; 7: 813-21.
7. Hoffmann B, Wang Y, Cumberland WG, et al. Serum beta-2-microglobulin level increases in HIV-1 infection : Relation to seroconversion, CD4 T-cell fall and prognosis. AIDS 1990; 4: 207-14.
8. Sabin CA, Phillips AN, Lee CA, et al. Beta-2-microglobulin levels as a predictor of prognosis in HIV-infected men with haemophilia: a proposed strategy for use in clinical care. Brit J Haem 1994; 36: 366-71.
9. Anderson RE, Lang W, Shiboski S, et al. Use of beta-2-microglobulin and CD4 lymphocyte count to predict development of acquired immunodeficiency syndrome in persons with human immunodeficiency virus infection. Ann Intern Med 1990; 150: 73-7.
10. Mocroft AJ, Johnson MA, Sabin CA, et al. Staging system for clinical AIDS patients. Lancet 1995; 346: 12-7.
11. Mills GD, Jones PL. Relationship between CD4 lymphocyte count and AIDS mortality, 1986-1991. AIDS 1993; 7: 1383-6.
12. Colford JM, Ngo L, Tager I. Factors associated with survival in Human Immunodeficiency Virus-infected patients with very low CD4 counts. Am J Epidemiol 1994; 139: 206-18.
13. Kerlikowske RM, Katz MH, Allen S, et al. Beta-2-microglobulin as a predictor of death in HIV-infected women from Kigali, Rwanda. AIDS 1994; 8: 963-9.
14. Coates RA, Farewell VT, Raboud J, et al. Using serial observations to identify predictors of progression to AIDS in the Toronto sexual contact study. J Clin Epidemiol 1992; 45: 245-53.
15. Phillips AN, Sabin CA, Elford J, et al. Acquired immunodeficiency syndrome (AIDS) risk in recent and long-standing human immunodeficiency virus type-1 (HIV-I) infected patients with similar CD4 lymphocyte counts. Am J Epidemiol 1993; 138: 870-8.
16. Phillips AN, Pezzotti P, Cozzi Lepri A, et al. CD4 lymphocyte count as a determinant of the time from HIV seroconversion to AIDS and death from AIDS: Evidence from the Italian seroconcerter study. AIDS 1994; 8: 1299-305.
17. Center for Disease Control. Revision of the surveillance case definition for the acquired immunodeficiency syndrome. MMWR 1987; 36: (No. S-1).
18. SAS institute Inc. SAS users guide: statistics, Version 6, 3rd edn. Cary, NC., 1990.
19. Kaplan EL, Meier P. Non parametric estimation from incomplete observations. J Am Stat Ass 1958; 53: 457-81.
20. Sabin CA. The follow-up of a cohort of anti-HIV seropositive Haemophiliacs for up to 15 years from seroconversion. London, England: University of London Thesis (1995).
21. Bofill M, Janossy G, Lee CA, et al. Laboratory control values for CD4 and CD8 t-lymphocytes. Implications for HIV-1 diagnosis. Clin Exp Immunol 1992; 88: 243-52.
22. Biggar RJ and the International Registry of Seroconverters. AIDS incubation period in 1891 seroconverters from different exposure groups. AIDS 1990; 4: 1059-66.
23. Goedert JJ, Kessler CM, Aledort L, et al. A prospective study of human immunodeficiency virus type-1 infection and the development of AIDS in subjects with haemophilia. N Engl J Med 1989; 321: 1141-8.
24. Carre N, Deveau C, Belanger F, et al. Effect of age and exposure group on the onset of AIDS in heterosexual and homosexual HIV-infected patients. AIDS 1994; 8: 797-802.
25. Ehmann WC, Eyster ME, Wilson SE, et al. Relationship of CD4 lymphocyte counts to survival in a cohort of haemophiliacs infected with HIV. J Acq Imm Defic Synd 1994; 7: 1095-8.
26. Vella S, Giuilano M, Floridia M, et al. Effect of sex, age and transmission category on the progression to AIDS and survival of zidovudine-treated symptomatic patients. AIDS 1995; 9: 51-6.
27. Chaisson RE, Keruly JC, Moore RD. Race, sex, drug use and progression of human immunodeficiency virus disease. N Engl J Med 1995; 333: 751-6.
28. Fischl MA, Richman D, Grieco MH, et al. The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. N Engl J Med 1987; 317: 185-91.
29. Kramer A, Biggar RJ, Hampl H, et al. Immunological markers of disease progression to acquired immunodeficiency syndrome are time-dependent and illness-specific. Am J Epidemiol 1992; 136: 71-80.
30. Munoz A, Vlahov D, Solomon D, et al. Prognostic indicators for the development of AIDS among intravenous drug users. J Acq Imm Defic Synd 1992; 5: 694-700.
31. Whittle H, Egboga A, Todd J, et al. Clinical and laboratory predictors of survival in Gambian patients with symptomatic HIV-1 or HIV-2 infection. AIDS 1992; 6: 685-9.
32. Verhofstede C, Reniers S, van Wanzeele F, Plum J. Evaluation of proviral copy number and plasma RNA level as early indicators of progression in HIV-1 infection: Correlation with virological and immunological markers of disease. AIDS 1994; 8: 1421-7.
33. Spijkerman IJB, Koot M, Prins M, et al. Lower prevalence and incidence of HIV-1 syncytium inducing phenotype among injecting drug users compared with homosexual men. AIDS 1995; 9: 1085-92.