Modulation of cytokine production from an EpiOcular corneal cell culture model in response to Staphylococcus aureus superantigen

Australian and New Zealand Journal of Ophthalmology

Volumn 25, Issue SUPPL. 1, 1997, Pages

  Thakur, A ^a   Clegg, A ^a   Chauhan, A ^a   Willcox, M D P ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

CLPU; Contact lens; Cytokines; EpiOcular corneal model; Staphylococcus aureus

Indexed keywords

CYTOKINE; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; LEUKOTRIENE B4; STAPHYLOCOCCUS ENTEROTOXIN B; SUPERANTIGEN;

ARTICLE; CELL CULTURE; CELL DEATH; CORNEA CELL; CORNEA EPITHELIUM; CYTOTOXICITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; MODEL; STAPHYLOCOCCUS AUREUS;

EID: 0030789791     PISSN: 08149763     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1442-9071.1997.tb01754.x     Document Type: Article

References (9)

1. Willcox MDP, Sweeney DF, Sharma S et al. Culture negative peripheral ulcers are associated with bacterial contamination of contact lenses. Invest. Ophthalmol. Vis. Sci. 1995; 36: S152.
2. Iandolo JJ. Genetic analysis of extracellular toxins of Staphylococcus aureus. Annu. Rev. Microbiol. 1989; 43: 375-402.
3. Tokura Y, Yagi J, O'Malley M et al. Superantigenic staphylococcal enterotoxins induced T-cell proliferation in the presence of Langerhans cells or class II-bearing keratinocytes and stimulate keratinocytes to produce T-cell activating cytokines. J. Invest. Dermatol. 1994; 102: 31-8.
4. Challegan MC, Engel L, Hill JM, O'Callaghan R. Corneal virulence of Staphylococcus aureus: roles of alpha-toxin and protein A in pathogenesis. Infect. Immunol. 1994; 62: 2478-82.
5. Smith RE. Chronic blepharitis: a review. CLAO J. 1995; 21: 200-7.
6. Limberg MB. A review of bacterial keratitis and bacterial conjunctivitis. Am. J. Ophthalmol. 1991; 112: S2-9.
7. Bjork L, Andersson J, Cheska M, Andersson U. Endotoxin and Staphylococcus aureus enterotoxin induce different patterns of cytokines. Cytokine 1992; 4: 513-19.
8. Krakauer T. Cell adhesion molecules are co-receptors for staphylococcal enterotoxin B-induced activation and cytokine production. Immunol. Lett. 1994; 39: 121-5.
9. Jett M, Brinkley W, Neill R, Gemski P, Hunt R. Staphylococcus aureus enterotoxin B challenge of monkeys: correlation of plasma levels of AA cascade products with occurrence of illness. Infect. Immunol. 1990; 58: 3494-9.