Transforming growth factor-β1 regulates the expression of Pax-2, a developmental control gene, in renal tubule cells

Experimental Nephrology

Volumn 5, Issue 4, 1997, Pages 295-300

  Liu, Shigang ^a   Cieslinski, Deborah A ^a   Funke, Angela J ^a   David Humes, H ^a,b  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Gene regulation; Growth factors; Kidney; mRNA stability

Indexed keywords

EPIDERMAL GROWTH FACTOR; GENE PRODUCT; MESSENGER RNA; MITOGENIC AGENT; RETINOIC ACID; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DOSE RESPONSE; GENE; GENE EXPRESSION; GENETIC TRANSCRIPTION; HALF LIFE TIME; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; RABBIT;

ANIMALS; CELL DIFFERENTIATION; CELL DIVISION; CELL NUCLEUS; CELLS, CULTURED; DNA PROBES; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; KIDNEY TUBULES, PROXIMAL; PAX2 TRANSCRIPTION FACTOR; RABBITS; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA, MESSENGER; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA; TRETINOIN;

EID: 0030789506     PISSN: 10187782     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Edelman GM: Topobiology: An Introduction to Molecular Embryology. New York, Basic Books, 1988.
2. Edelman GM: Morphoregulation. Dev Dynamics 1992;193:2-10.
3. Saxen L: Organogenesis of the Kidney. Cambridge, Cambridge University Press, 1987.
4. Walther C, Guenet J, Simon D, Deutsch U, Jostes B, Goulding MD, Plachov D, Balling R, Gruss P: Pax: A murine multigene family of paired box-containing genes. Genomics 1991; 11:424-434.
5. Dressler GR, Deutsch U, Chowdhury K, Nornes HO, Gruss P: Pax 2, a new murine paired-box-containing gene and its expression in the developing excretory system. Development 1990;109:787-795.
6. Rothenspieler UW, Dressler GR: Pax-2 is required for mesenchyme-to-epithelium conversion during kidney development. Development 1993;119:711-720.
7. Dressler GR, Wilkinson JE, Rothenspieler UW, Patterson LT, Williams-Simons L, Westphal H: Deregulation of Pax-2 expression in transgenic mice generates severe kidney abnormalities. Nature 1993;362:65-67.
8. Keller SA, Jones JM, Boyle A, Barrow LL, Killen PD, Green DG, Kapousta NV, Hitchcock PF, Swank RT, Meisler MH: Kidney and retinal defects (Krd), a transgene-induced mutation with a deletion of mouse chromosome 19 that includes the Pax2 locus. Genomics 1994; 23:309-320.
9. Torres M, Gómez-Pardo E, Dressler GR, Gruss P: Pax-2 controls multiple steps of Urogenital development. Development 1995;121: 4057-4065.
10. Sanyanusin P, Schimmenti LA, McNoe LA, Ward TA, Pierpont MEM, Sullivan MJ, Dobyns WB, Eccles MR: Mutation of the PAX2 gene in a family with optic nerve colobomas, renal anomalies and vesicoureteral reflux. Nature Genet 1995;9:358-364.
11. Winyard PJD, Risdon RA, Sams VR, Dressler GR, Woolf AS: The PAX2 transcription factor is expressed in cystic and hyperproliferative dysplastic epithelia in human kidney malformations. J Clin Invest 1996;98:451-459.
12. Rogers SA, Ryan G, Hammerman MR: Insulin-like growth factors I and II are produced in the metanephros and are required for growth and development in vitro. J Cell Biol 1991;113: 1447-1453.
13. Rogers SA, Ryan G, Hammerman MR: Metanephric transforming growth factor-α is required for renal organogenesis in vitro. Am J Physiol 1992;262:F533-F539.
14. Heine UI, Munoz EF, Flanders KC, Ellingsworth LR, Lam HY, Thompson NL, Roberts AB, Sporn MB: Role of transforming growth factor-β in the development of the mouse embryo. J Cell Biol 1987;105:2861-2876.
15. Lehnert SA, Akhurst RJ: Embryonic expression pattern of TGF beta type-1 RNA suggests both paracrine and autocrine mechanisms of action. Development 1988;104:263-273.
16. Millan FA, Denhez F, Kondaiah P, Akhurst RJ: Embryonic gene expression patterns of TGF β1, β2, and β3 suggest different development functions in vivo. Development 1991; 111:131-144.
17. Schmid P, Cox D, Bilbe G, Maier R, McMaster GK: Differential expression of TGF β1, β2, and β3 genes during mouse embryogenesis. Development 1991;111:117-130.
18. Rossant J, Zirngibl R: Expression of a retinoic acid response element-hsplacZ transgene defines specific domains of transcriptional activity during mouse embryogenesis. Genes Dev 1991;5:1333-1344.
19. Humes HD, Cieslinski DA: Interaction between growth factors and retinoic acid in the induction of kidney tubulogenesis. Exp Cell Res 1992;201:8-15.
20. Humes HD, Cieslinski DA, Johnson LB, Sanchez IO: Triiodothyronine enhances epidermal growth factor induced mitogenesis in renal tubule cells by stimulating EGF receptor gene expression. Am J Physiol 1992;262:F540-F545.
21. Dressler GR, Douglass EC: Pax-2 is a DNA-binding protein expressed in embryonic kidney and Wilms' tumor. Proc Natl Acad Sci USA 1992;89:1179-1183.
22. Groudine M, Peretz M, Weintraub LT: Transcriptional regulation of hemoglobin switching in chicken embryos. Mol Cell Biol 1981;1:281-288.
23. Slack JMW: From Egg to Embryo, ed 2. Cambridge, Cambridge University Press, 1991.
24. Raff RA, Kaufman TC: Embryos, Genes and Evolution. Ames, Indiana University Press, 1983.
25. Scott MP, Tamkun JW, Hartzell GW: The structure and function of the homeodomain. Biochim Biophys Acta 1989;989:25-48.
26. Kessel M, Gruss P: Murine developmental control genes. Science 1990;249:374-379.
27. Ryan G, Steele-Perkins V, Morris J, Rauscher FJ, Dressler GR: Repression of Pax-2 by WT1 during normal kidney development. Development 1995;121:867-875.
28. Humes HD, Beals TF, Cieslinski DA, Sanchez IO, Page TP: Effects of transforming growth factor-alpha, transforming growth factor-beta and other growth factors on renal proximal tubule cells. Lab Invest 1991;64:538-545.
29. Humes HD, Nakamura T, Cieslinski DA, Miller D, Emmons RV, Border WA: Role of proteoglycans and cytoskeleton in the effects of TGF-B1 on renal proximal tubule cells. Kidney Int 1993;43:575-584.
30. Hentze MW: Determinants and regulation of cytoplasmic mRNA stability in eukaryotic cells. Biochim Biophys Acta 1991;1090:281-292.