Effect of drug particle size on content uniformity of low-dose solid dosage forms

International Journal of Pharmaceutics

Volumn 154, Issue 2, 1997, Pages 179-183

  Zhang, Ying ^a   Johnson, Kevin C ^a  

^a PFIZER INC   (United States)

Author keywords

Computer simulation; Content uniformity; Low dose; Particle size

Indexed keywords

CALCIUM PHOSPHATE DIBASIC; CHOLINESTERASE INHIBITOR; CP 118954; EXCIPIENT; MICROCRYSTALLINE CELLULOSE; STARCH GLYCOLATE SODIUM; UNCLASSIFIED DRUG;

ARTICLE; COMPUTER SIMULATION; DENSITY; DRUG DOSAGE FORM; MASS; PARTICLE SIZE; PRIORITY JOURNAL;

EID: 0030789163     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(97)00134-8     Document Type: Article

References (2)

1. Villalobos, A., Butler, T.W., Chapin, D.S., Chen, Y.L., De-Mattos, S.B., Ives, J.L., Jones, S.B., Liston, D.R., Nagel, A.A., Nason, D.M., Nielsen, J.A., Ramirez, A.D., Shalaby, I.A., White, W.F., 1995. 5,7-Dihydro-3-[2-[1-(phenylmethyl)-4-piperidinyl]ethyl]-6H-pyrrolo[3,2-f]-1,2- benzisoxazol-6-one: a potent and centrally-selective inhibitor of acetylcholinesterase with an improved margin of safety. J. Med. Chem. 38, 2802-2808.
2. Yalkowsky, S.H., Bolton, S., 1990. Particle size and content uniformity. Pharm. Res. 7, 962-966.