High performance liquid chromatographic assay for cisatracurium and its metabolites in human urine

Journal of Liquid Chromatography and Related Technologies

Volumn 20, Issue 13, 1997, Pages 2041-2051

  Bryant, B J ^a   James Jr , Charles D ^a   Ryan Cook, D ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATRACURIUM BESILATE; DRUG METABOLITE; LAUDANOSINE;

ACCURACY; ARTICLE; CALIBRATION; CATION EXCHANGE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG STABILITY; DRUG URINE LEVEL; FLUORESCENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; INTRAVENOUS DRUG ADMINISTRATION; NORMAL HUMAN; QUANTITATIVE ASSAY; TECHNIQUE; URINARY EXCRETION;

EID: 0030788567     PISSN: 10826076     EISSN: None     Source Type: Journal    
DOI: 10.1080/10826079708005563     Document Type: Article

References (5)

1. R. M. Welch, A. R. Brown, R. Dahl "The In Vitro Degradation of Cisatracurium, the R,Cis-R',Cis Isomer of Atracurium, in Human and Rat Plasma," Clin. Pharm. & Therap., 58(2), 132-142 (1995).
2. R. L. Stiller, D. R. Cook, S. Chakravorti, "In vitro Degradation of Atracurium in Human Plasma," Br. J. Anaesth., 57, 1085-1088 (1985).
3. C. D. James, M. O'Mara, C. Rawls, B. J. Bryant, L. Kanics, G. Ridout, G. Lovell, J. C. Harrelson "A High-Performance Liquid Chromatographic Assay for the Quantitation of Cisatracurium and its Metabolites in Human Plasma," Submitted for internal review; Prepared for Journal of Chromatography.
4. G. Lovell, J. Morgan, "The Analysis of the Geometric Isomers of Atracurium and Principal Metabolites in Biological Fluids Using Solid-Phase Extraction and Gradient Cation Exchange HPLC with Fluorescence Detection," 2nd International Symposium on Pharmaceutical and Biomedical Analysis, 4-7 Apr 1990.
5. M. R. Belmont, R. B. Maehr, W. B. Wastila, J. J. Savarese, "Pharmacodynamics and Pharmacokinetics of Benzylisoquinolinium (Curare-Like) Neuromuscular Blocking Agents," Anes. Clin. of North America, Quarterly Review, 2(2), June 1993.