Glutamate decarboxylase (GAD67 and GAD65) gene expression is increased in a subpopulation of neurons in the putamen of Parkinsonian monkeys

Synapse

Volumn 27, Issue 2, 1997, Pages 122-132

  Soghomonian, Jean Jacques ^a,b   Laprade, Nathalie ^a  

^a UNIVERSITÉ LAVAL   (Canada)

^b LAVAL UNIVERSITY   (Canada)

Author keywords

Caudate nucleus; GAD65; GAD67; Glutamic acid decarboxylase; Monkey; MPTP; Parkinson's disease; Putamen

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; GENE PRODUCT; GLUTAMATE DECARBOXYLASE; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAUDATE NUCLEUS; CELL SUBPOPULATION; CONTROLLED STUDY; ENZYME INDUCTION; ENZYME LOCALIZATION; ENZYME POLYMORPHISM; GABAERGIC SYSTEM; GENE EXPRESSION; NERVE PROJECTION; NONHUMAN; PARKINSONISM; PRIORITY JOURNAL; PUTAMEN; SQUIRREL MONKEY;

ANIMALS; DISEASE MODELS, ANIMAL; GENE EXPRESSION; GLUTAMATE DECARBOXYLASE; IN SITU HYBRIDIZATION; NEURONS; PARKINSON DISEASE; PUTAMEN; RNA, MESSENGER; SAIMIRI;

EID: 0030788119     PISSN: 08874476     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2396(199710)27:2<122::AID-SYN3>3.0.CO;2-G     Document Type: Article

References (40)

1. Albin, R., Young, A., and Penney, G.R. (1989) The functional anatomy of basal ganglia circuits: Neural substrates of parallel processing. Trends Neurosci., 12:366-375.
2. Aronin, N., DiFiglia, M., Graveland, G.A., Schwartz, W.J., and Wu, J.-Y. (1984) Localization of immunoreactive enkephalins in GABA synthesizing neurons of the rat neostriatum. Brain Res., 300:376-380.
3. Asselin, M.-C., Soghomonian, J.-J., Côté, P.-Y., and Parent, A. (1994) Striatal changes in preproenkephalin mRNA levels in parkinsonian monkeys. Neuroreport, 5:2137-2140.
4. Bu, D.F., Erlander, M.G., Hitz, B.C., Tillakaratne, N.J.K., Kaufman, D.L., Wagner, M.E.G.A., and Tobin, A.J. (1992) Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene. Proc. Natl. Acad. Sci. USA, 89:283-292.
5. Cenci, M.A., Campbell, K., and Björklund, A. (1993) Neuropeptide messenger RNA expression in the 6-hydroxydopamine-lesioned rat striatum reinnervated by fetal dopaminergic transplants: Differential effects of the grafts on preproenkephalin, preprotachykinin and prodynorphin messenger RNA levels. Neuroscience, 57:275-296.
6. Chesselet, M.-F., and Robbins, E. (1989) Characterization of striatal neurons expressing high levels of glutamic acid decarboxylase messenger RNA. Brain Res., 492:237-244.
7. Chesselet, M.-F., Weiss, L.T., Wuenschell, C., Tobin, A.J., and Affolter, H.U. (1987) Comparative distribution of mRNAs for glutamic acid decarboxylase, tyrosine hydroxylase and tachykinins in the basal ganglia: An in situ hybridization study in the rodent brain. J. Comp. Neurol., 262:125-140.
8. Cox, K.H., DeLeon, D.V., Angerer, L.M., and Angerer, R.C. (1984) Detection of mRNAs in sea urchin embryos by in situ hybridization using asymmetric RNA probes. Dev. Biol., 101:485-502.
9. Cruz, C.J., and Beckstead, R.M. (1989) Nigrostriatal dopamine neurons are required to maintain basal levels of substance P in the rat substantia nigra. Neuroscience, 30:331-338.
10. Emmers, R., and Akert, K. (1963) A Stereotaxic Atlas of the Brain of the Squirrel Monkey (Saimiri sciureus). University of Wisconsin Press, Madison, 102 pages.
11. Gerfen, C.R., and Young, S.Y. (1988) Distribution of striatonigral and striatopallidal peptidergic neurons in both patch and matrix compartments: An in situ hybridization histochemistry and fluorescent retrograde tracing study. Brain Res., 460:161-167.
12. Gerfen, C.R., Engber, T.M., Mahan, L.C., Susel, Z., Chase, T.N., Monsma, F.J., and Sibley, D.R. (1990) D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons. Science, 250:1429-1431.
13. Gonzales, C., Kaufman, D.L., Tobin, A.J., and Chesselet, M.-F. (1991) Distribution of glutamic acid decarboxylase (Mrs 67,000) in the basal ganglia of the rat: An immunohistochemical study with selective cDNA-generated polyclonal antibody. J. Neurocytol., 20: 953-961.
14. Herrero, M.-T., Augood, S.J., Hirsch, E.C., Javoy-Agid, F., Luquin, M.R., Agid, Y., Obeso, J.A., and Emson, P.C. (1995) Effects of L-DOPA on preproenkephalin and preprotachykinin gene expression in the MPTP-treated monkey striatum. Neuroscience, 68:1189-1198.
15. Jolkkonen, J., Jenner, P., and Marsden, C.D. (1995) L-DOPA reverses altered gene expression of substance P but not enkephalin in the caudate-putamen of common marmosets treated with MPTP. Mol. Brain Res., 32:297-307.
16. Kita, H., and Kitai, S.T. (1988) Glutamate decarboxylase immunoreactive neurons in rat neostriatum: Their morphological types and populations. Brain Res., 44:346-352.
17. Lavoie, B., Parent, A., and Bedard, P. (1991) Effects of dopamine denervation on striatal peptide expression in parkinsonian monkeys. J. Can. Neurol. Sci., 18:373-375.
18. Levy, R., Herrero, M.T., Ruberg, M., Villares, J., Faucheux, B., Guridi, J., Guillen, J., Luquin, M.R., Javoy-Agid, F. Obeso, J.A., Agid, Y., and Hirsch, E.C. (1995) Effects of nigrostriatal denervation and L-DOPA therapy on the GABAergic neurons of the striatum in MPTP-treated monkevs and Parkinson's disease: An in situ hybridization study of GAD67 mRNA. Eur. J. Neurosci., 7:1199-1209.
19. Li, S.J., Sivam, S.P., McGinty, J.F., Jiang, H.K., Douglass, J., Calavetta, L., and Hong, J.S. (1988) Regulation of the metabolism of striatal dynorphin by the dopaminergic system. J. Pharmacol. Exp. Ther., 246:403-408.
20. Lindefors, N., Brené, S., Herrera-Marschitz, M., and Persson, H. (1989a) Region specific regulation of glutamic acid decarboxylase mRNA expression by dopamine neurons in rat brain. Exp. Brain Res., 77:611-620.
21. Lindefors, N., Brodin, E., Tossman, U., Segovia, J., and Ungerstedt, U. (1989b) Tissue levels and in vivo release of tachykinins and GABA in striatum and substantia nigra of rat brain after unilateral striatal dopamine denervation. Exp. Brain Res., 74:527-534.
22. Mercugliano, M., Soghomonian, J.-J., Qin, Y., Nguyen, H.Q., Feldblum, S., Erlander, M.G., Tobin, A.J., and Chesselet, M.-F. (1992) Comparative distribution of messenger RNAs encoding glutamic acid decarboxylases (Mr 65,000 and Mr 67,000) in the basal ganglia of the rat. J. Comp. Neurol., 318:245-254.
23. Nisbet, A.P., Foster, O.J.F., Kingsbury, A., Eve, D.J., Daniel, S.E., Marsden, C.D., and Lees, A.J. (1995) Preproenkephalin and preprotachykinin messenger RNA expression in normal human basal ganglia and in Parkinson's disease. Neuroscience, 66:361-376.
24. Pan, H.S., Penney, J.B., and Young, A.B. (1985) Gamma-aminobutyric acid and benzodiazepine receptor changes induced by unilateral 6-hydroxydopamine lesions of the medial forebrain bundle. J. Neurochem., 45:1396-1404.
25. Pedneault, S., and Soghomonian, J.-J. (1994) Glutamate decarboxylase (GAD65) mRNA levels in the striatum and pallidum of parkinsonian primates. Mol. Brain Res., 25:351-354.
26. Pérez-Otaño, I., Herrero, M.T., Luquin, M.R., Obeso, J.A., and Del Río, J. (1992) Chronic MPTP treatment reduces substance P and metenkephalin content in the basal ganglia of the marmoset. Brain Res., 585:156-160.
27. Robertson, R.G., Graham, W.C., Sambrook, M.A., and Crossman, A.R. (1991) Further investigations into the pathophysiology of MPTP-induced parkinsonism in the primate: An intracerebral microdialysis study of gamma-aminobutyric acid in the lateral segment of the globus pallidus. Brain Res., 563:278-280.
28. Roeling, T.A.P., Docter, G.J., Voorn, P., Melchers, B.P.C., Wolters, E.C., and Groenewegen, H. J. (1995) Effects of unilateral 6-hydroxydopamine lesion on neuropeptide immunoreactivity in the basal ganglia of the common marmoset, Callithrix jacchus, a quantitative immunohistochemical analysis. J. Chem. Neuroanat., 9:155-164.
29. Segovia, J., Tossman, U., Herrera, M.M., Garcia, M.M., and Ungerstedt, U. (1986) Gamma-aminobutyric acid release in the globus pallidus in vivo after 6-hydroxydopamine lesion in the substantia nigra of the rat. Neurosci. Lett., 70:364-368.
30. Segovia, J., Tillakaratne, N.J.K., Whelan, K., Tobin, A.J., and Gale, K. (1990) Parallel increases in striatal glutamic acid decarboxylase activity and mRNA levels in rats with lesions of the nigrostriatal pathway. Brain Res., 529:345-348.
31. Smith, Y., Parent, A., Séguéla, P., and Descarries, L. (1987) Distribution of GABA-immunoreactive neurons in the basal ganglia of the squirrel monkey. J. Comp. Neurol., 259:50-64.
32. Soghomonian, J.-J., Gonzales, C., and Chesselet, M.-F. (1992) Messenger RNAs encoding glutamate decarboxylases are differentially affected by nigrostriatal lesions in subpopulations of striatal neurons. Brain Res., 567:68-79.
33. Soghomonian, J.-J., Pedneault, S., Audet, G., and Parent, A. (1994) Increased glutamate decarboxylase mRNA levels in the striatum and pallidum of MPTP-treated primates. J. Neurosci., 14:6256-6265.
34. Soghomonian, J.-J., Pedneault, S., Blanchet, P.J., Goulet, M., Di Paolo, T., and Bédard, P.J. (1996) L-DOPA regulates glutamate decarboxylases mRNA levels in MPTP-treated monkeys. Mol. Brain Res., 39:237-240.
35. Tossman, U., Segovia, J., and Ungerstedt, U. (1986) Extracellular levels of amino acids in striatum and globus pallidus of 6-hydroxydopamine-lesioned rats measured with microdialysis. Acta Physiol. Scand., 127:547-551.
36. Uhl, G.R., Navia, B., and Douglas, J. (1988) Differential expression of preproenkephalin and preprodynorphin mRNAs in striatal neurons: High levels of preproenkephalin expression depend on cerebral cortical afferents. J. Neurosci., 8:4755-4764.
37. Vernier, P., Julien, J.-F., Rataboul, P., Fourrier, O., Feuerstein, C., and Mallet, J. (1988) Similar time course changes in striatal levels of glutamic acid decarboxylase and proenkephalin mRNA following dopaminergic deafferentation in the rat. J. Neurochem., 51:1375-1380.
38. Voorn, P., Roest, G., and Groenewegen, H.J. (1987) Increase of enkephalin and decrease of substance P immunoreactivity in the dorsal and ventral striatum of the rat after midbrain 6-hydroxytryptamine lesions. Brain Res., 412:391-396.
39. Young, W.S., Bonner, T.I., and Brann, M.R. (1986) Mesencephalic dopamine neurons regulate the expression of neuropeptide mRNAs in the rat forebrain. Proc. Natl. Acad. Sci. USA, 83:9827-9831.
40. Zamir, N., Skofitsch, G., Bannon, M.J., Heike, C.J., Kopin, I.J., and Jacobowitz, D.M. (1984) Primate model of Parkinson's disease: Alterations in multiple opioid systems in the basal ganglia. Brain Res., 322:356-360.