Arginine-glycine-aspartic acid mimics can identify a transitional activation state of recombinant αIIbβ3 in human embryonic kidney 293 cells

Molecular Pharmacology

Volumn 52, Issue 2, 1997, Pages 227-236

  Abraham, Dicky G ^a   Nutt, Elka M ^a   Bednar, Rodney A ^a   Bednar, Bohumil ^a   Gould, Robert J ^a   Duong, Le T ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; ARGINYLGLYCYLASPARTIC ACID; COLLAGEN; CYCLOPEPTIDE; ECHISTATIN; FIBRINOGEN; INTEGRIN; LAMIFIBAN; RECEPTOR SUBUNIT; THROMBIN; THROMBOCYTE RECEPTOR;

ARTICLE; BINDING AFFINITY; CELL AGGREGATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYTOPLASM; DISSOCIATION; EMBRYO; ERYTHROLEUKEMIA CELL; HUMAN; HUMAN CELL; LIGAND BINDING; MOLECULAR MIMICRY; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN DOMAIN; RECEPTOR AFFINITY; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

EID: 0030788111     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.52.2.227     Document Type: Article

References (39)

1. Hynes, R. O. Integrins: versatility, modulation, and signaling in cell adhesion. Cell 69:11-25 (1992).
2. Loftus, J. C., J. W. Smith, and M. H. Ginsberg. Integrin-mediated cell adhesion: the extracellular face. J. Biol. Chem. 269:25235-25238 (1994).
3. Haas, T. A., and E. F. Plow. Integrin-ligand interactions: a year in review. Curr. Opin. Cell Biol. 6:656-662 (1994).
4. 3 subunit: cation displacement is involved in ligand binding. Cell 79:659-667 (1994).
5. Ginsberg. M. H., X. Du, and E. F. Plow. Inside-out integrin signaling. Curr. Opin. Cell Biol. 4:766-791 (1992).
6. Shattil, S. J., and J. S. Brugge. Protein tyrosine phosphorylation and the adhesive functions of platelets. Curr. Opin. Cell Biol. 3:869-879 (1991).
7. 1-integrin-linked protein kinase. Nature (Lond.) 379:91-96 (1996).
8. 3 subunit. J. Cell Biol. 131:807-816 (1995).
9. 2 integrin/LFA-1 binding to ICAM-1 induced by cytohesin-1, a cytoplasmic regulatory molecule. Cell 86:233-242 (1996).
10. Sastry, S. K., and A. F. Horwitz. Integrin cytoplasmic domains: mediators of cytoskeletal linkages and extra- and intracellular initiated transmembrane signaling. Curr. Opin. Cell Biol. 5:819-831 (1993).
11. Shattil, S. J., and L. F. Brass. Induction of the fibrinogen receptor on human platelets is mediated by intracellular mediators. J. Biol. Chem. 262:992-1000 (1987).
12. Shattil, S. J., M. Cunningham, T. Weidmer, J. Zhao, P. J. Sims, and L. F. Brass. Regulation of glycoprotein IIb-IIIa receptor function studied with platelets permeabilized by the pore-forming complement proteins C5b-9. J. Biol. Chem. 267:18429-18431 (1992).
13. Sims, P. J., M. H. Ginsberg, E. F. Plow, and S. J. Shattil. Effect of platelet activation on the conformation of the plasma membrane glycoprotein IIb-IIIa complex. J. Biol. Chem. 266:7345-7352 (1991).
14. Philips, D. R., I. F. Charo, L. V. Parise, and L. A. Fitzgerald. The platelet membrane glycoprotein IIb-IIIa complex. Blood 71:831-843 (1988).
15. Haverstick, D. M., J. F. Cowan, K. M. Yamada, and S. A. Santoro. Inhibition of platelet adhesion to fibronectin, fibrinogen, and von Willebrand factor substrates by a synthetic tetrapeptide derived from the cell-binding domain of fibronectin. Blood 66:946-952 (1985).
16. 3 (platelet GPIIb-IIIa). Cell 65:409-416 (1991).
17. Frelingher, A. L., III, S. C.-T. Lam, E. F. Plow, M. A. Smith, J. C. Loftus, and M. H. Ginsberg. Occupancy of an adhesion glycoprotein receptor modulates expression of antigenic site involved in cell adhesion. J. Cell Biol. 263:12397-12402 (1988).
18. Frelingher, A. L., III, I. Cohen, E. F. Plow, M. A. Smith, J. Roberts, C.-T. Lam, and M. H. Ginsberg. Selective inhibition of integrin function by antibodies specific for ligand-occupied receptor conformations. J. Biol. Chem. 265:6346-6352 (1990).
19. Smyth, S. S., C. C. Joneckis, and L. V. Parise. Regulation of vascular integrins. Blood 81:2827-2843 (1993).
20. 3 (glycoprotein IIb-IIIa) in a variant of Glanzmann thrombasthenia. Proc. Natl. Acad. Sci. USA 89:10169-10173 (1992).
21. Shattil, S. J., J. A. Hoxie, M. Cunningham, and L. F. Brass. Changes in the platelet membrane glycoprotein IIb-IIIa complex during platelet activation. J. Biol. Chem. 260:11107-11114 (1985).
22. Egbertson, M. S., B. Bednar, R. A. Bednar, G. D. Hartman, R. J. Gould, R. J. Lynch, L. M. Vassallo, and S. D. Young. Non-peptide glycoprotein IIb/IIIa inhibitors: centrally constrained alpha-sulfonamides are useful tools for exploring platelet receptor function. Bioorg. Med. Chem. Lett. 6:1415-1420 (1996)
23. Larsson, A., and T. L. Lindahl. Inhibition of fibrinogen binding to platelets by MK-852, a new GPIIb/IIIa antagonist. J. Med. Sci. 99:121-129 (1994).
24. Duggan, M. E., A. M. Naylor-Olsen, J. J. Perkins, P. S. Anderson, C. T. C. Chang, J. J. Cook, R. J. Gould, N. C. Ihle, G. D. Hartman, and J. J. Lynch. Non-peptide fibrinogen receptor antagonists: design and synthesis of a potent, orally active fibrinogen receptor antagonist. J. Med. Chem. 38: 3332-3341 (1995).
25. Kouns, W. C., D. Kirchofer, P. Hadváry, A. Edenhofer, T. Weller, G. Pfenninger, H. R. Baumgartner, L. K. Jennings, and B. Steiner. Reversible conformational changes induced in glycoprotein IIb-IIIa by a potent and selective peptidomimetic inhibitor. Blood 80:2539-2547 (1992).
26. Bennett, J. S., M. A. Kolodziej, G. Vilaire, and M. Poncz. Determinants of the intracellular fate of truncated forms of the platelet glycoproteins IIb and IIIa. J. Biol. Chem. 268:3580-3585 (1993).
27. 1-mediated cell migration on fibronectin. Mol. Biol. Cell 7:3408 (1996).
28. 3. Thromb. Haemostasis 69:785 (1993).
29. O'Toole, T. E., J. Ylanne, and B. M. Culley. Regulation of integrin affinity state through an NPXY motif in the β subunit cytoplasmic domain. J. Biol. Chem. 270:8553-8558 (1995).
30. Taub, R., R. J. Gould, V. M. Garsky, T. M. Ciccarone, J. Hoxie, P. A. Friedman, and S. J. Shattil. A monoclonal antibody against the platelet fibrinogen receptor contains a sequence that mimics a receptor recognition domain in fibrinogen. J. Biol. Chem. 264:259-265 (1989).
31. Gould, R. J., M. A. Polokoff, P. A. Friedman, T. F. Huang, J. C. Holt, J. J. Cook, and S. Niewiarowski. Disintegrins: a family of integrin inhibitory proteins from viper venoms. Proc. Soc. Exp. Biol. Med. 195:168-171 (1990).
32. Hughes, P. E., F. Diaz-Gonzaloz, L. Leong, C. Wu, J. A. McDonald, S. J. Shattil, and M. H. Ginsberg. Breaking the integrin hinge: a defined structural constraint regulates integrin signaling. J. Biol. Chem. 271:6571-6574 (1996).
33. Savage, B., and Z. M. Ruggeri. Selective recognition of adhesive sites in surface-bound fibrinogen by glycoprotein IIb-IIIa on nonactivated platelets. J. Biol. Chem. 266:11227-11233 (1991).
34. Nakatani, S., T. Hato, Y. Minamoto, and S. Fujita. Differential inhibition of fibrinogen binding to agonist- and RGDS peptide-activated states of GPIIb-IIIa by an anti-GPIIIa monoclonal antibody, PMA5. Thromb. Haemostasis 76:1030-1037 (1996).
35. 3. J. Biol. Chem. 271:20315-20321 (1996).
36. Furihata, K., D. J. Nugent, A. Bissonette, R. H. Aster, and T. Kunicki. On the association of the platelet-specific alloantigen, Pena, with glycoprotein IIIa: evidence for heterogeneity of glycoprotein IIIa. J. Clin. Invest. 80: 1624-1630 (1987).
37. 1 integrin from different cell types shows different binding affinities. J. Biol. Chem. 265:615-618 (1990).
38. Fujimoto, T., K. Fujimura, M. Noda, T. Takafuta, T. Shimomura, and A. Kuramoto. 50-Kd integrin-associated protein does not detectably influence several functions of glycoprotein IIb-IIIa complex in human platelets. Blood 86:2174-2182 (1995).
39. Pullman, W. E., and W. F. Bodmer. Cloning and characterization of a gene that regulates cell adhesion. Nature (Lond.) 365:529-533 (1992).