Effect of wortmannin and 2-(4-morpholinyl)8-phenyl-4H-1-benzopyran-4- one (LY294002) on N-formyl-methionyl-leucyl-phenylalanine-induced phospholipase D activation in differentiated HL60 cells: Possible involvement of phosphatidylinositol 3-kinase in phospholipase D activation

Biochemical Pharmacology

Volumn 53, Issue 12, 1997, Pages 1929-1936

  Nakamura, Mitsuhiro ^a   Nakashima, Shigeru ^b   Katagiri, Yoshihiro ^a   Nozawa, Yoshinori ^b  

^a GIFU UNIVERSITY HOSPITAL   (Japan)

^b GIFU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

HL60 cell; LY294002; Phosphatidylinositol 3 kinase; Phospholipase D; Wortmannin

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ANTIINFLAMMATORY AGENT; ARACHIDONIC ACID; FORMYLMETHIONYLLEUCYLPHENYLALANINE; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE D; TRITIUM; WORTMANNIN;

ANTIINFLAMMATORY ACTIVITY; ARACHIDONIC ACID METABOLISM; ARTICLE; CELL DIFFERENTIATION; CELL STRAIN HL 60; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LEUKOCYTE ACTIVATION; NEUTROPHIL; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; CELL DIFFERENTIATION; CELL MEMBRANE; CHROMONES; ENZYME ACTIVATION; HL-60 CELLS; HUMANS; MORPHOLINES; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE; PHOSPHATIDYLINOSITOL PHOSPHATES; PHOSPHODIESTERASE INHIBITORS; PHOSPHOLIPASE D; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); TETRADECANOYLPHORBOL ACETATE;

EID: 0030787558     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(97)00169-X     Document Type: Article

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