Biochemical and functional antigenic mimicry by a polyclonal anti-ldiotypic antibody for chlamydial exoglycolipid antigen

Pathobiology

Volumn 65, Issue 5, 1997, Pages 229-240

  An, Ling Ling ^a   Hudson, Alan P ^b   Prendergast, Robert A ^c   Brien, Terrence P O ^d   Stuart, Elizabeth S ^a   Whittum Hudson, Judith A ^c   Mac Donald, A Bruce ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c Ocular Immunology Service   (United States)

^d JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Anti Anti idiotype; Anti Id antibody; Chlamydia trachomatis; Exoglycolipid; Idiotype; Neutralization; Trachoma; Vaccine

Indexed keywords

ANTIIDIOTYPIC ANTIBODY; BACTERIAL ANTIGEN; BACTERIAL VACCINE; BACTERIUM ANTIBODY; GLYCOLIPID; MONOCLONAL ANTIBODY; POLYCLONAL ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; CHLAMYDIA TRACHOMATIS; CHLAMYDIASIS; CONTROLLED STUDY; FEMALE; GUINEA PIG; HUMAN; IMMUNIZATION; IMMUNOGENICITY; MALE; PRIORITY JOURNAL; RABBIT;

ANIMALS; ANTIBODIES, ANTI-IDIOTYPIC; ANTIBODIES, BACTERIAL; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; ANTIGENS, BACTERIAL; CHLAMYDIA TRACHOMATIS; FEMALE; GLYCOLIPIDS; GUINEA PIGS; IMMUNOGLOBULIN G; MACACA FASCICULARIS; MOLECULAR MIMICRY; NEUTRALIZATION TESTS; POLYSACCHARIDES, BACTERIAL; RABBITS; TRACHOMA; VACCINATION;

ANIMALIA; BACTERIA (MICROORGANISMS); CAVIA; CAVIA PORCELLUS; CHLAMYDIA TRACHOMATIS; CHLAMYDIAE; ORYCTOLAGUS CUNICULUS; SUS SCROFA;

EID: 0030787187     PISSN: 10152008     EISSN: 14230291     Source Type: Journal    
DOI: 10.1159/000164134     Document Type: Article

References (77)

1. Blanchard TG. An L. Troidlc KM, Tirrcll SM. MacDonald AG: Internal image of cxoglycolip-id genus-specific antigen produced by antiidiotype: in Bowie WR. Caldwell HD. Jones RP. Mardh P. Ridgway GL. Schachtcr J, Stamm WE, Ward ME (eds): Chlamydial Infections. Cambridge, Cambridge University Press, 1990, pp 205-208.
2. Brunham RC. Peeling RW: Chlamydia trachomatis antigens: Role in immunity and pathogenesis. Infect Agents Dis 1994:3:218-233.
3. Conlan JW. Ferris S, Clarke IN, Ward ME: Isolation of recombinant fragments of the major outer-membrane protein of Chlamydia trachomatis: Their potential as subunit vaccines. J Gen Microbiol 1990;136:2013-2020.
4. Conlan JW. Ferris S. Clarke IN. Ward ME: Surface-exposed epitopes on the major outer-membrane protein of Chlamydia trachomatis defined with peptide antisera. J Gen Microbiol 1989:135:3219-3228.
5. Hayes U. Conlan JW. Everson JS. Ward ME. Clarke IN: Chlamydia trachomatis major outer membrane protein epitopes expressed as fusions with LaniB in an attenuated aro A strain of Salmonella typhimurium: their application as potential immunogens. J Gen Mierobiol 1991:137:1557-1564.
6. Knight SC, Iqball S, Woods C. Stagg A. Ward ME. Tufl'rey M: A peptide of Chlamydia trachomatis shown to be a primary T-cell epitope in vitro induces cell-mediated immunity in vivo. Immunology 1995:85:8-15.
7. Cheng X. Pal S. de la Maza LM, Peterson EM: Characterization of the humoral response induced by a peptide corresponding to variable domain IV of the major outer membrane protein of Chlamydia trachomatis scrovar E. Infect Immun 1992:60:3428-3432.
8. Qu Z. Cheng X. de la Maza LM. Peterson EM: Comparison of immunization routes and adjuvants on the humoral response of mice to a peptide to the variable segments 1 and 4 of Chlamydia trachomatis: in Orfila JE. Bvrnc GI. Chemcsky MA. Grayston JT. Jones RB. Ridgway GL, Saikku P. Schachter J. Stamm WE. Stephens RS: Chlamydial Infections. Bologna. Socicta Editrice Esculapio. 1994. pp 145-147.
9. Murdin AD. Su H. Klein MH, Caldwell HD: Poliovirus hybrids expressing neutralization epitopes from variable domains I and IV of the major outer membrane protein of Chlamydia trachomatis elicit broadly cross-reactive C tra-chomatis-ncutraIizing antibodies. Infect Immun 1995:63:1116-1121.
10. Murdin AD. Su H. Manning DS. Klein MIL, Parnell MJ. Caldwell HD: A poliovirus hybrid expressing a neutralization epitope from the major outer membrane protein of Chlamydia trachomatis is highly immunogenic. Infect Immun 1993:61:4406-4414.
11. Stuart ES. Troidlc KM. MacDonald AB: Chlamydial glvcolipid antigen: Extracellular accumulation. biological activity, and antibody recognition. Curr Microbiol 1994:28:85-90.
12. Stuart ES. Wyrick PB, Choong J. Stolcr SB. MacDonald AB: Examination of chlamydial glvcolipid with monoclonal antibodies: Cellular distribution and epitope binding. Immunology 1991:74:740-747.
13. Stuart ES. Tirrcll SM. MacDonald AB: Characterization of an antigen secreted by chlamydial infected cell culture. Immunology 1987:61: 527-533.
14. Stuart ES. MacDonald AB: Identification of two fatty acids in a group determinant of Chlamydia trachomatis. Curr Microbiol 1984:11: 123-128.
15. Stuart ES, MacDonald AB: Some characteristics of a secreted chlamydial antigen recognized by IgG from Chlamydia trachomatis patient sera. Immunology 1989;68:469-473.
16. Stuart ES. MacDonald AB: Isolation of a possible goup determinant of Chlamydia trachomatis: in Mardh PA. Holmes KK. Oriel JD. Piot P, Schachter J (eds): Chlamydial Infections. New York, Elsevier Biomedical. 1982, pp 57-60.
17. Poskitt DC. Jcan-Frangois MJ. Turnbull S. Macdonald L. Yasmeen D: Internal image (Ab2beta) anti-idiotype vaccines. Theoretical and practical aspects. Vaccine 1991;9:792-796.
18. Jerne NK: Towards a network theory of the immune system. Ann Immunol 1974:125:373-389.
19. Nisonoff A: Idiotypcs: Concepts and applications. J Immunol 1991:147:2429-2438.
20. Greenspan NS. Bona CA: Idiotypes: Structure and immunogenicity. FASEB J 1993:7:437-444.
21. Rees ADM, Scorging A. Dobson N. Praputpittaya K. Young P. Ivanyi J, Lamb JR: T cell activation by anti-idiotypic antibody: Mechanism of interaction w ith antigen-reactive T cell. Eur J Immunol 1987:17:197-201.
22. Nisonof TA. La Moyi E: Implications of the presence of an internal image of the antigen in anti-ld antibodies: Possible application to vaccine production. Clin Immunol Immunopathol 1981;21:397-406.
23. Su S. Ward MM. Apicella MA. Ward RE: A nontoxic, idiotope vaccine against gram-negative bacterial infections. J Immunol 1992:148: 234-238.
24. Rajewsky K. Takemorc T: Genetics. expression and functions of idiotypes. Ann Rev Immunol 1983;52:283-331.
25. Fields BA. Goldbaum FA. Ysem X. Poljak RJ. Mariuzza RA: Molecular basis of antigen mimicry by an anti-idiotope. Proc Natl Acad Sci USA 1995:374:739-742.
26. Sege K. Peterson PA: Use of anti-idiotypic antibodies as cell-surface receptor probes. Proc Natl Acad Sci USA 1978:75:2443-2447.
27. Rolf JM. Gaudin HM. Tirrell SM. Mac Donald B. Fidels L: Anti-idiotypic antibodies that protect cells against the action of diphtheria toxin. Proc Natl Acad Sci USA 1989:86:2036-2039.
28. Su SD. Ward MM. Apicella MA, Ward RE: Analysis of the immune response to lipopoly-saccharide. Existence of an interspecies cross-reactive idiotype associated with anti-lipid A antibodies. J Immunol 1990:145:2994-3001.
29. Monafo WJ, Greenspan NS. Cebra-Thomas JA. Davie JM: Modulation of the murine immune response to streptococcal goup A carbohydrate by immunization with monoclonal anti-idiotope. J Immunol 1987; 139:2702-2707.
30. Schretber JR. Dahlhauscr P: Immunogenicity of tetanus toxoid conjugates of anti-idiotypes that mimic Pseudomonas aeruginosa surface polysaccharides. Infect Immun 1994:62:308-312.
31. Stein KE: Network regulation of the immune response to bacterial polysaccharide antigens. Curr Top Microbiol Immunol 1985; 119:57-74.
32. Weslerink MA. Giardina PC. Apicella MA. Kieber-Emmons T: Peptide mimicry of the meningococcal group C capsular polysaccharide. Proc Natl Acad Sci USA 1995:92:4021-4025.
33. Chapman PB. Livingston PO. Morrison ME. Williams L, Houghton AN: Immunization of melanoma patients with antiidiotypic monoclonal antibody BEC2 (which mimics GD3 gangliosidc): Pilot trials using no immunological adjuvant. Vaccine Res 1994;3:59-69.
34. McCaffery M. Yao TJ. Williams L, Livingston PO. Houghton AN, Chapman PB: Immunization of melanoma patients with BEC2 antiidiotypic monoclonal antibody that mimics GD3 ganglioside: Enhanced immunogenicity when combined with adjuvant. Clin Cancer Res 1996:2:679-686.
35. Schreibcr JR, Cooper LJ. Diehn S. Dahlhauscr span NS: Variable region-identical monoclonal antibodies of different IgG subclass directed to Pseudomonas aeruginosa lipopolvsaccharidc O-spccific side chain function differently. J Infect Dis 1993:167:221-226.
36. Schn'iber JR, Patawaran M. Tosi MF. Lennon J, Pier GB: Anti-idiotype-induccd. lipopolysac-charide-specific antibody response to Pseudomonas aeruginosa. J Immunol 1990:144:1023-1029.
37. Whittum-Hudson JA. Taylor HR: Antichlamy-dial specificity of conjunctival lymphocytes during experimental ocular infection. Infect Immun 1989:57:2977-2983.
38. Whittum-Hudson JA. An L-L. MacDonald AB. Prendergasl RA. Saltzman WM: Oral immunization with an anti-idiotypic antibody to the exoglvcolipid antigen protects against experimental Chlamydia trachomatis infection. Nat Med 1996:2:1116-1121.
39. Campos M. Pal S. O'Brien TP. Taylor HR. Prendergasl RA. Whittum-Hudson JA: A chlamydial major outer membrane protein extract as a trachoma vaccine candidate. Invest Ophthalmol Vis Sci 1995:36:1477-1491.
40. Pal S. Taylor HR. Hunckc RB. Premlcrgast RA. Whittum-Hudson JA: Frequency of antigen-specific B cells during experimental ocular Chlamydia trachomatis infection. Infect Im-mun 1992;60:5294-5297.
41. Pal S. Pu Z, Hunckc RB. Taylor HR. Whittum-Hudson JA: Chlamydia-specific lymphocytes in conjunctiva during ocular infection: Limiting dilution analysis. Reg Immunol 1990:3: 171-176.
42. Taylor HR. Bell T: Chlamydial infections: in Strickland G (cd): Hunter's Tropical Medicine. Philadelphia. Saunders. 1984. pp 233-238.
43. An LL: Production and characterization of anti-idiotypic antibodies, biological mimicry of a glycolipid exoantigen of Chlamydia trachomatis in vivo. PhD thesis. Universtiv of Massachusetts, Amherst, 1993.
44. Hourihan JT. Rota TR. MacDonald AB: Isolation and purification of a type-specific antigen from Chlamydia trachomatis propagated in cell culture utilizing molecular shift chromatography. J Immunol 1980:124:2399-2404.
45. Martin LN: Separation of guinea pig IgG subclasses by affinity chromatography on protein A-scpharose. J Immunol Methods 1982:52: 205-212.
46. Scieux C. Bianchi A. Vassias I. Meouchv R. Felten A, Morel P. Perol Y: Evaluation of a new chemiluminometric immunoassay, Magic Lite Chlamydia, for detecting Chlamydia trachomatis antigen from urogenital specimens. Sex Transm Dis 1992;19:161-164.
47. Harlow F. Lane D: Antibodies: A Laboratory Manual. Cold Spring Harbor, Cold Spring Harbor Laboratory'. 1988, pp 139-243.
48. Su H. Caldwell HD: In vitro neutralization of Chlamydia trachomatis by monovalent Fab antibody specific to the major outer membrane protein. Infect Immun 1991:59:2843-2845.
49. Bvme GL. Stephens RS. Ada G. Caldwell HD. Su H. Morrison RP, Van der Pol B, Bavoil P. Bobo L. Everson S, Ho Y. Hsia RC. Kennedy K. Kuo C. Montgomery PC. Peterson E. Swanson A. Whitaker C, Whittum-Hudson J. Yang CL. Zhang Y, Zhong GM: Workshop on in vitro neutralization of Chlamydia trachomatis: Summary of proceedings. J Infect Dis 1993: 168:415-420.
50. Taylor HR. Velez VI.: Clearance of chlamydial elementary bodies from the conjunctival sac. Invest Ophthalmol Vis Sci 1987:28:1199-1201.
51. Taylor HR. Agarwala N. Johnson SL: Detection of experimental Chlamydia trachomatis eye infection in conjunctival smears and in tissue culture by use of fluorescein-conjugated monoclonal antibody. J Clin Microbiol 1984: 20:391-395.
52. Taylor HR. Johnson SL. Prcndergast RA. Schachter J. Dawson CR. Silverstein AM: An animal model of trachoma II. The importance of repeated reinfection. Invest Ophthalmol Vis Sci 1982:23:507-515.
53. Cheema MA. Schumacher HR. Hudson AP: RNA-directed molecular hybridization screening: Evidence for inapparem chlamydial infection. Am J Med Sci 1991:302:261-268.
54. Holland SM. Hudson AP. Bobo L. Whittum-Hudson JA. Viscidi RP. Quinn TC. Taylor HR: Demonstration of chlamydial RNA and DNA during a culture-negative state. Infect Immun 1992:60:2040-2047.
55. Hudson AP. McEntcc CM. Reacher M. Whittum-Hudson JA, Taylor HR: Inapparcnt ocular infection by Chlamydia trachomatis in experimental and human trachoma. Curr Eye Res 1992:11:279-283.
56. Eichmann K: Expression and function of idio-types of lymphocytes. Adv Immunol 1978:26: 195-254.
57. Pride MW. Shi H. Anchin JM. Linthicum DS. LoVerde PT, Thakur A. Thanavala Y: Molecular mimicry of hepatitis B surface antigen by an anti-idiotype-derived synthetic peptide. Proc Natl Acad Sci USA 1992:89:11900-11904.
58. Thanavala Y: Novel approaches to vaccine development against HBV. J Biotechnol 1996:44:67-73.
59. Westerink MA. Apicella MA: Anti-idiotypic antibodies as vaccines against carbohydrate antigens. Springer Semin Immunopalhol 1993; 15:227-234.
60. Yang YF. Thanavala Y: A comparison of the antibody and T cell responses elicited by internal image and noninternal image antiidio-Ivpcs. Clin Immunol Immunopathol 1995:75: 154-158.
61. Taylor HR. Prcndergast RA. Dawson CR, Schachter J. Silverstein AM: An animal model for cicatrizing trachoma. Invest Ophthalmol Vis Sci 1981;21:422-433.
62. Beutler A. Whittum-Hudson JA. Schumacher R. Hudson AP: Intracellular location of inap-parcntly-infcctingchlamydia in synovial tissue from patients with Reiter's syndrome. Immunol Res 1994:13:163-171.
63. Nanagara R. Li F, Beutler A. Hudson A. Schumacher HR Jr: Alteration of Chlamydia trachomatis biologic behavior in synovial membranes. Suppression of surface antigen production in reactive arthritis and Reiter's syndrome. Arthritis Rheum 1995:38:1410-1417.
64. Barenfanger J, MacDonald AB: The role of immunoglobulin in the neutralization of trachoma infectivity. J Immunol 1974:113:1607-1617.
65. Howard LV: Neutralization of Chlamydia trachomatis in cell culture. Infect Immun 1975; 11:698-703.
66. Zhang YX. Stewart S. Joseph T. Taylor HR. Caldwell HD: Protective monoclonal antibodies recognize epitopes located on the major outer membrane protein of Chlamydia trachomatis J Immunol 1987:138:575-581.
67. Peeling RW. Brunham RC: Neutralization of Chlamydia trachomatis: Kinetics and stoichiometry. Infect Immun 1991;59:2624-2630.
68. Brunham RC. Peeling R. Maclean I. McDowell L. Persson K. Osser S: Posl-abortal Chlamydia trachomatis salpingitis: Correlating risk with antigen-specific responses and with neutralization. J Infect Dis 1987;155:749-755.
69. Caldwell HD, Perry LJ: Neutralization of Chlamydia trachomatis infectivity with antibodies to the major outer membrane protein. Infect Immun 1982;38:745-754.
70. Brossay L. Villeneuve A. Paradis G. Cote L. Mourad W. Hebert J: Mimicry of a neutralizing epitope of the major outer membrane protein of Chlamydia trachomatis by anti-idiotvp-ic antibodies. Infect Immun 1994:62:341-347.
71. Batteger BE. Rank RG. Bavoil PM. Soderberg LSF: Partial protection against genital reinfection by immunization of guinea pigs with isolated outer membrane proteins of the chlamydial agent guinea pig inclusion conjunctivitis. J Gen Microbiol 1993;139:2965-2972.
72. Dhir SP, Hakomori S. Kenny GE, Grayston JT: Immunochemical studies on chlamydial group antigen (presence of a 2-keto-3-deoxycar-bohydrate as immunodominant group). J Immunol 1972:109:116-122.
73. Zhang JP. Stephens RS: Mechanism of C. trachomatis attachment to eukaryotic host cells. Cell 1992:69:861-869.
74. Swanson AF, Kuo C: Binding of the glycan of the major outer membrane protein of Chlamydia trachomatis to HeLa cells. Infect Immun 1994;62:24-28.
75. Swanson AF. Kuo CC: The 18-kDa lcctin-bind-ing protein of Chlamydia trachomatis is different from the 18-kDa histone-like protein. FEMS Microbiol Lett 1996:137:189-192.
76. Jackson S, Mesteckv J. Childers NK. Michalek SM: Liposomes containing anti-idiotypic antibodies: An oral vaccine to induce protective secretory immune responses specific for pathogens of mucosal surfaces. Infect Immun 1990: 58:1932-1936.
77. Westerink MA, Campagnari AA. Wirth MA, Apicella MA: Development and characterization of an anti-idiotypic antibody to the capsular polysaccharide oNeisseria meningitidis se-rogroupC'. Infect Immun 1988:56:1120-1127.