Early genetic and functional events in the pathogenesis of oral cancer

Radiation Oncology Investigations

Volumn 5, Issue 3, 1997, Pages 93-96

  Prime, S S ^a   Eveson, J W ^a   Guest, P G ^a   Parkinson, E K ^b   Paterson, I C ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

Author keywords

Carcinoma; Culture; Genes; Oral; Premalignant

Indexed keywords

CANCER GENETICS; CARCINOGENESIS; CELL AGING; CONFERENCE PAPER; HUMAN; KERATINOCYTE; MOUTH CANCER; MOUTH CARCINOMA; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA;

ANIMALS; CARCINOMA; CARCINOMA, SQUAMOUS CELL; CELL DEATH; CELL DIFFERENTIATION; CELL DIVISION; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; CHROMOSOMES, HUMAN, PAIR 17; CHROMOSOMES, HUMAN, PAIR 3; CHROMOSOMES, HUMAN, PAIR 9; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, P53; GENES, TUMOR SUPPRESSOR; HUMANS; KERATINOCYTES; MICE; MICE, NUDE; MOUTH MUCOSA; MOUTH NEOPLASMS; PHENOTYPE; PRECANCEROUS CONDITIONS; TUMOR CELLS, CULTURED;

EID: 0030786953     PISSN: 10657541     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1520-6823(1997)5:3<93::AID-ROI1>3.0.CO;2-D     Document Type: Conference Paper

References (19)

1. Langdon JD, Henk JM: Malignant Tumours of the Mouth, Jaws, and Salivary Glands, 2nd Ed. Edward Arnold, 1995.
2. Eveson JW: Oral premalignancy. Cancer Surveys 2: 403-424, 1983.
3. Califano J, van der Riet P, Westra W, Nawroz H, Clayman G, Piantadosi S, Corio R, Lee D, Greenberg B, Koch W, Sidransky D: Genetic progression model for head and neck cancer: Implications for field cancerization. Cancer Res 56:2488-2492, 1996.
4. Gujuluva CN, Baek JH, Shin KH, Cherrick HM, Park NH: Effect of UV-irradiation on cell-cycle, viability and the expression of p53, Gadd153 and Gadd45 genes in normal and HPV-immortalized human oral keratinocytes. Oncogene 9:1819-1827, 1994.
5. Somers KD, Merrick MA, Lopez ME, Incognito LS, Schechter GL, Casey G: Frequent p53 mutations in head and neck cancer. Cancer Res 52:5997-6000, 1992.
6. Boyle JO, Hakim J, Koch W, van der Riet P, Hruban RH, Roa A, Correo R, Eby YJ, Ruppert M, Sidransky D: The incidence of p53 mutations increases with progression of head and neck cancer. Cancer Res 53:4477-4480, 1993.
7. Paterson IC, Eveson JW, Prime SS: Molecular changes in oral cancer may reflect aetiology and ethnic origin. Oral Oncol, Eur J Cancer 323:150-153, 1996.
8. Pavelic ZP, Lasmar M, Pavelic LJ, Sorensen C, Stambrook PJ, Zimmermann N, Gluckman JL: Absence of retinoblastoma gene product in human primary oral cavity carcinomas. Oral Oncol, Eur J Cancer 32B:347-351, 1996.
9. Yeudall WA, Jakus J: Cyclin kinase inhibitors add a new dimension to cell cycle control. Oral Oncol, Eur J Cancer 316:291-298, 1995.
10. Roz L, Wu CL, Porter S, Scully C, Speight P, Read A, Sloan P, Thakker N: Allelic imbalance on chromosome 3p in oral dysplastic lesions: An early event in oral carcinogenesis. Cancer Res 56:1228-1231, 1996.
11. Virgilio L, Shuster M, Gollin SM, Veronese ML, Ohta M, Huebner K, Croce CM: FHIT gene alterations in head and neck squamous cell carcinomas. Proc Natl Acad Sci USA 93:9770-9775, 1996.
12. Markowitz SD, Roberts AB: Tumor suppressor activity of the TGF-β pathway in human cancers. Cytokine Growth Factor Rev 7:93-102, 1996.
13. Prime SS, Matthews JB, Patel V, Game SM, Donnelly M, Stone A, Paterson IC, Sandy JR, Yeudall WA: TGF-β receptor regulation mediates the response to exogenous ligand but is independent of the degree of cellular differentiation in human oral keratinocytes. Int J Cancer 56:406-412, 1994.
14. Prime SS, Nixon SVR, Crane IJ, Stone A, Matthews JB, Maitland NJ, Remnant L, Powell SK, Game SM, Scully C: The behaviour of human oral squamous cell carcinoma in cell culture. J Pathol 160:259-269, 1990.
15. Chang SE, Foster S, Betts D, Marnock WE: DOK, a cell line established from human dysplastic oral mucosa, shows a partially transformed nonmalignant phenotype. Int J Cancer 52:896-902, 1992.
16. Sacks PG: Cell, tissue and organ culture as in vitro models to study the biology of squamous cell carcinomas of the head and neck. Cancer Metastases Rev 15: 27-51, 1996.
17. Edington KG, Loughran OP, Berry IJ, Parkinson K: Cellular immortality: A late event in the progression of human squamous cell carcinoma of the head and neck associated with p53 alteration and a high frequency of allele loss. Mol Carcinogenes 13:254-265, 1995.
18. Loughran O, Edington KG, Berry IJ, Clark LJ, Parkinson EK: Loss of heterozygosity of chromosome 9p21 is associated with the immortal phenotype of neoplastic human head and neck keratinocytes. Cancer Res 54: 5045-5049, 1994.
19. Parkinson EK: Do telomerase antagonists represent a novel anticancer strategy? Br J Cancer 73:1-4, 1996.