Metabolism of progesterone by human lymphocytes: Production of neuroactive steroids

Journal of Clinical Endocrinology and Metabolism

Volumn 82, Issue 12, 1997, Pages 4064-4068

  Leb, Colette R ^a   Hu, Fen Yun ^a   Murphy, Beverley E Pearson ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b MONTREAL GENERAL HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 3BETA HYDROXY 5ALPHA PREGNAN 20 ONE; 5ALPHA PREGNANE 3,20 DIONE; CORTICOSTERONE; HYDROCORTISONE; NEUROSTEROID; PROGESTERONE; TESTOSTERONE;

ARTICLE; CONTROLLED STUDY; FOLLICULAR PHASE; HUMAN; HUMAN CELL; LACTATION; LUTEAL PHASE; LYMPHOCYTE; NEUROENDOCRINOLOGY; NORMAL HUMAN; PREGNANCY; PRIORITY JOURNAL; PROGESTERONE METABOLISM;

EID: 0030786809     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.82.12.4064     Document Type: Article

References (17)

1. Dougherty TF, Berliner DL, Berliner ML. 1961 Corticosteroid-tissue interactions. Metabolism. 10:966-987.
2. Forker AD, Bolinger RE, Morris JH, Larson WE. 1963 Metabolism of cortisol-C14 by human peripheral leukocyte cultures from leukemic patients. Metabolism. 12:751-759.
3. Jenkins JS, Kemp NH. 1969 Metabolism of cortisol by human leukemic cells. J Clin Endocrinol Metab. 29:1217-1221.
4. Klein A, Kaufmann H, Mannheimer S, Joshua H. 1978 Cortisol metabolism in lymphocytes from cancer-bearing patients. Metabolism. 27:731-736.
5. Clair P, Patricot MC, Mathian B, Revol A. 1984 Androgen metabolism, in vitro by human leukocytes. Variations with sex and age. J Steroid Biochem. 29:377-381.
6. van der Molen HJ, Groen D. 1968 Interconversion of progesterone and 20α-dihydroprogesterone and of androstenedione and testosterone in vitro by blood and erythrocytes. Acta Endocrinol. 58:419-444.
7. Selye H. 1942 Correlations between the chemical structures, and the pharmacological actions of the steroids. Endocrinology. 30:4437-4453.
8. Gyermek L, Soyka LF. 1975 Steroid anesthetics. Anaesthesiology. 42:331-344.
9. Holzbauer M. 1971 Physiological aspects of steroids with anesthetic properties. Med Biol. 54:227-243.
10. Dhar V, Stark R, Kraulis I, Murphy BEP. 1986 Contrasting effects of 5α- and 5β-pregnane-3,20-dione on the motor activity of ovariectomized rats. J Steroid Biochem. 26:577-580.
11. Majewska MKD, Harrison NL, Schwartz RD, Barker L. 1986 Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor. Science. 232:1004-1008.
12. Mellon SH. 1994 Neurosteroids: Biochemistry, modes of action, and clinical relevance. J Clin Endocrinol Metab. 78:1003-1008.
13. Purdy RH, Moore Jr PH, Rao PH. 1981 Analysis of progestins. In: Kautsky MP, ed. Steroid analysis by HPLC. New York: Marcel Dekker.
14. Tan SY, Murphy BEP. 1974 Specificity of the progesterone-binding globulin of the guinea pig. Endocrinology. 94:122-127.
15. Murphy BEP. 1967 Some studies of the protein-binding of steroids and their application to the routine micro- and ultramicro measurement of various steroids in body fluids by competitive protein-binding radioassay. J Clin Endocrinol Metab. 227:973-990.
16. Murphy BEP, Marvin M. 1974 Interaction of gelatin with stereospecific binding proteins and its enhancement of competitive binding assays. J Clin Pathol. 27:687-692.
17. Grant JK. 1962 Studies on the biogenesis of the adrenal steroids. Br Med Bull. 18:99-105.