Curative radiotherapy (RT) using limited RT treatment fields in elderly patients with non-small cell lung cancer in clinical stage IIIa: A phase II study

Oncology Reports

Volumn 4, Issue 5, 1997, Pages 961-965

  Pergolizzi, Stefano ^a,b,d   Settineri, Nicola ^a,b   Maisano, Roberto ^a,b   Santacaterina, Anna ^a,b   Faranda, Carmelo ^a,b   Russi, Elvio G ^c   Raffaele, Luigi ^a,b   Adamo, Vincenzo ^b  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF MESSINA   (Italy)

^c S CROCE E CARLE HOSPITAL   (Italy)

^d Hospital 'S Croce e Carle' ^*  (Italy)

Author keywords

Elderly; Lung cancer; Radiotherapy

Indexed keywords

AGED; AGING; ARTICLE; CANCER STAGING; CANCER SURVIVAL; CLINICAL ARTICLE; CLINICAL FEATURE; CLINICAL TRIAL; HUMAN; INOPERABLE CANCER; LUNG NON SMALL CELL CANCER; MALE; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; PROGNOSIS; RADIATION DOSE;

EID: 0030785843     PISSN: 1021335X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Mountain CF: The new international system for staging lung cancer. Chest 89: 225-233S, 1986.
2. Ginsberg RJ, Kris MG and Armstrong JG: Cancer of the lung: section 1. Non-small cell lung cancer. In: Cancer: Principles and Practice of Oncology. 4th edition. DeVita VT, Hellman S and Rosenberg SA (eds). JB Lippincott, Philadelphia pp673-723, 1993.
3. Noordijk EM, Poest-Clement EVD, Hermans J, Wever AMJ and Leer JWH: Radiotherapy as an alternative to surgery in elderly patients with resectable lung cancer. Radiother Oncol 13: 83-89, 1988.
4. Sandler HM, Curran WJ Jr and Turrisi AT III: The influence of tumor size and pre-treatment stagin on outcome following radiation therapy alone for stage I non-small cell lung cancer. Int J Radiat Oncol Biol Phys 19: 9-13, 1990.
5. Green MR and Lilenbaum RC: Stage IIIa category of non-small cell lung cancer. A new proposal. J Natl Cancer Inst 86: 586-588, 1994.
6. Neal C, Amdur R, Mendenhall W, Knauf D, Block A and Million R: Pancoast tumor: radiation therapy alone versus preoperative radiation plus surgery. Int J Radiat Oncol Biol Phys 21: 651-660, 1991.
7. Dillman RO, Seagren SL and Propert K: A randomized trial of induction chemotherapy plus high-dose radiation vs radiation alone in stage III non-small cell lung cancer. N Engl J Med 323: 940-945, 1990.
8. Sause WT, Scott C and Taylor S: Radiation Therapy Oncology Group (RTOG) 88-08 and Eastern Cooperative Oncology Group (ECOG) 4588: preliminary results of a phase III trial in regionally advanced, unresectable non-small-cell lung cancer. J Natl Cancer Inst 87: 198-205, 1995.
9. Dillman RO: Concurrent chemoradiation in unresectable stage III non-small cell lung cancer: too much pain for no gain. Cancer J Sci Am 2: 76-78, 1996.
10. Dosoretz DE, Katin MJ, Blitzer PH, Rubenstein JH, Salenius S, Rashid M, Dosani RA, Mestas G, Siegel AD, Chadha TT, Chandrahasa T, Hannan SE, Bhat SB and Metke M: Radiation therapy in the management of medically inoperable carcinoma of the lung: results and implications for future treatment strategies. Int J Radiat Oncol Biol Phys 24: 3-9, 1992.
11. American Thoracic Society: Clinical staging of primary lung cancer. Am Rev Respir Dis 127: 659-664, 1983.
12. Cummings-Ajemian I: Treatment of related symptoms. In: Cancer Pain. Patt RB (ed). JB lippincott, Philadelphia pp197-208, 1993.
13. Practical Nonparametric Statistics. 2nd edition. Conover WJ (ed). John Wiley & Sons, Inc, New York, 1980.
14. Kaplan G and Meier P: Non parametric estimation from incomplete observations. J Amer Statist Assn 53: 457-481, 1958.
15. Gehan EA: A generalized Wilcoxon test for comparing arbitrarily singly-censored data. Biometrics 36: 607-625, 1965.
16. Cox DR: Regression models and life-table. Statistic Soc 34: 187-220, 1972.
17. National Cancer Institute Update. Annual Cancer Statistics Update December 8, 1986. National Cancer Institute, Bethesda, MD, 1986.
18. Zagonel V, Tirelli U, Serraino D, Lo Re G, Merola MC, Mascarin M, Trovò MG, Carbone A and Monfardini S: The aged patient with lung cancer. Management recommendations. Drugs Aging 4: 34-46, 1994.
19. Hazuka M and Bunn P: Controversies in the nonsurgical treatment of stage III non-small cell lung cancer. Am Rev Respir Dis 145: 967-977, 1992.
20. Van Houtte P, Gregor A and Philips P: International survey of radiotherapy practice for radical treatment of non-small cell lung cancer. Lung Cancer 11: 129-138, 1994.
21. Graham MV, Matthews JW, Harms WB, Emami B, Glazer HS and Purdy JA: Three dimensional radiation treatment planning study for patients with carcinoma of the lung. Int J Radiat Oncol Biol Phys 29: 1105-1117, 1994.
22. Shaw EG: Thoracic radiation therapy (TRT) for unresectable non-small cell lung cancer (NSCLC). In: Educational Book ASCO, 30th Annual Meeting, 1994. Dallas, TX pp196-202, 1994.
23. Emami B and Perez CA: Lung. In: Principles and Practice of Radiation Oncology. 2nd edition. Perez CA and Brady LW (eds). JB Lippincott, Philadelphia, pp806-836, 1992.
24. Lee JS, Scott C, Komaky R, Fossella FV, Dundas GS, McDonald S, Byhardt RW and Curran WJ: Concurrent chemoradiation therapy with oral etoposide and cisplatin for locally advanced inoperable non-small-cell lung cancer: Radiation Therapy Oncology Group. Protocol 91-06. J Clin Oncol 14: 1055-1064, 1996.
25. Coen V, Van Lancker M, De Neve W and Storme G: Prognostic factors in locoregional non-small cell lung cancer treated with radiotherapy. Am J Clin Oncol (CCT) 18: 111-117, 1995.
26. Koga K, Kusumoto S, Watanabe K, Nishikawa K, Harada K and Ebihara H: Age factor relevant to the development of radiation pneumonitis in radiotherapy of lung cancer. Int J Radiat Oncol Biol Phys 14: 367-371, 1988.
27. Bergman B, Aaronson NK, Ahmedzai S, Kaasa S and Sullivan for the EORTC Study Group on Quality of Life: The EORTC QLQ-LC13: a modular supplement to the EORTC core quality of life questionnaire (QLQ-C30) for use in lung cancer clinical trials. Eur J Cancer 30A: 635-642, 1994.
28. Perez CA, Pajak TF and Rubin P: Long-term observations of the patterns of failure in patients with unresectable non-oat cell carcinoma of the lung treated with definitive radiotherapy: report by the radiation therapy oncology group. Cancer 59: 1874-1881, 1987.
29. Stanley KE: Prognostic factors for survival in patients with inoperable lung cancer. J Natl Cancer Inst 65: 25-32, 1980.
30. Ganz PA, Lee JJ and Siau J: Quality of life assessment, an independent prognostic variable for survival in lung cancer. Cancer 67: 3131-3135, 1991.
31. ICRU, Report No.50, Prescribing, Recording, and Reporting Photon Beam Therapy. International Commission on Radiation Units and Measurements, Washington, DC, 1993.