Prevention of gastrointestinal iron absorption by chelation from an orally administered premixed deferoxamine/charcoal slurry

Annals of Emergency Medicine

Volumn 30, Issue 5, 1997, Pages 587-592

  Gomez, H F ^a   McClafferty, H H ^a   Flory, D ^a   Brent, J ^a   Dart, R C ^a  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED CARBON; DEFEROXAMINE; FERROUS SULFATE;

ADULT; AREA UNDER THE CURVE; ARTICLE; DRUG BLOOD LEVEL; FEMALE; HUMAN; HUMAN EXPERIMENT; INTESTINE ABSORPTION; IRON ABSORPTION; IRON CHELATION; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

EID: 0030785302     PISSN: 01960644     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0196-0644(97)70073-8     Document Type: Article

References (25)

1. TL Litovitz LR Clark RA Soloway 1993 Annual report of the AAPCC toxic exposure surveillance system Am J Emerg Med 12 1994 546 584
2. W Banner TG Tong Iron poisoning Pediatr Clin North Am 33 1986 393 409
3. WJ Decker HF Combs DG Corby Adsorption of drugs and poisons by activated charcoal Toxicol Appl Pharmacol 13 1968 454 460
4. M Tenenbein Whole bowel irrigation in iron poisoning J Pediatr 111 1987 142 145
5. K Kulig D Bar-or SV Cantrill Management of acutely poisoned patients without gastric emptying Ann Emerg Med 14 1985 562 567
6. M Tenenbein Inefficacy of gastric emptying procedure J Emerg Med 3 1985 133 136
7. KS Merigian M Woodard JR Hedges Prospective evaluation of gastric emptying in the self-poisoned patient Am J Emerg Med 8 1990 479 483
8. SM Pond DJ Lewis-Driver GM Williams Gastric emptying in acute overdose: A prospective randomized controlled trial Med J Aust 163 1995 345 349
9. P Czajka JD Konrad JP Duffy Brief clinical and laboratory observations J Pediatr 98 1981 491 494
10. B Dean E Krenzelok In vivo effectiveness of oral complexation agents in the management of iron poisoning Clin Toxicol 25 1987 221 230
11. B Dean FW Oehme E Krenzelok A study of iron complexation in a swine model Vet Hum Toxicol 30 1988 313 315
12. CF Whitten Y Chen GW Gibson Studies in acute iron poisoning II: Further observations on desferrioxamine in the treatment of acute experimental iron poisoning Pediatrics 38 1966 102 111
13. CF Whitten GW Gibson MH Good Studies in acute iron poisoning: Desferrioxamine in the treatment of acute iron poisoning. Clinical observations, experimental studies, and theoretical considerations Pediatrics 36 1965 322 334
14. JT McEnery J Greengard Treatment of acute iron ingestion with deferoxamine in 20 children J Pediatr 68 1965 773 779
15. S Moeschlin Schnider U: treatment of primary and secondary hemochromatosis and acute iron poisoning with a new potent eliminating agent (desferrioxamine-B) N Engl J Med 269 1963 57 66
16. TW Jackson LJ Ling V Washington The effect of oral deferoxamine on iron absorption in humans J Toxicol Clin Toxicol 33 1995 325 329
17. TMS Chang P Barre Effect of desferrioxamine on removal of aluminum and iron by coated charcoal haemoperfusion and haemodialysis Lancet 2 1983 1051 1053
18. J Yonker W Banner A Picchioni Absorption characteristics of iron and deferoxamine onto charcoal Vet Hum Toxicol 22 suppl 1980 75
19. HF Gomez H McClafferty R Horowitz Adsorption of iron to a premixed deferoxamine/ charcoal slurry [abstract] Vet Hum Toxicol 35 1993 366
20. JT DiPiro RA Blouin JM Pruemer Concepts in Clinical Pharmacology 1988 American Society of Hospital Pharmacists Bethesda, Maryland
21. M Tenenbein S Kowalski A Sienko Pulmonary toxic effects of continuous deferioxamine administration in acute iron poisoning Lancet 339 1992 699 701
22. W Westlin Deferoxamine in the treatment of acute iron poisoning: Clinical experiences with 172 children Clin Pediatr 5 1966 531 535
23. American Society of Hospital Pharmacists: AHFS Drug Information 1990 1993 American Society of Hospital Pharmacists Bethesda, Maryland 1874 1875
24. Desferrioxamine (mesylate) Sir Colin Dollery Therapeutic Drugs 1991 Churchill Livingstone London D28 D32
25. JF Goodwin CF Whitten Chelation of ferrous sulfate solutions by desferrioxamine B Nature 205 1965 281