Effect of SR-140333, a neurokinin-1 receptor antagonist, on airway reactivity to methacholine in sedated rats

Acta Pharmacologica Sinica

Volumn 18, Issue 6, 1997, Pages 485-488

  Tian, Jiong ^a   Wei, Er Qing ^a   Chen, Ji Su ^a   Zhang, Wei Ping ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Albuterol; Aminophylline; Atropine; Dexamethasone; Methacholine chloride; Neurokinin 1 receptors; SR 140333; Trachea

Indexed keywords

AMINOPHYLLINE; ATROPINE; DEXAMETHASONE; METHACHOLINE; NEUROKININ 1 RECEPTOR ANTAGONIST; NOLPITANTIUM; SALBUTAMOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTHMA; BRONCHUS HYPERREACTIVITY; BRONCHUS MUSCLE; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; PROVOCATION TEST; RAT; TRACHEA MUSCLE;

ALBUTEROL; ANIMALS; ATROPINE; FEMALE; MALE; METHACHOLINE CHLORIDE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; PIPERIDINES; QUINUCLIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NEUROKININ-1; RESPIRATION; TRACHEA;

EID: 0030784790     PISSN: 02539756     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Ding DJ, Martin JG, Macklem FT. Effects of lung volume on maximal methacholine-induced bronchoconstriction in normal humans. J Appl Physiol 1987; 62: 1324-30.
2. Bellofiore S, Martin JG. Antigen challenge of sensitized rats increases airway responsiveness to methacholine. J Appl Physiol 1988; 65: 1642-6.
3. Maggi CA, Giachetti A, Dey RD, Said SI. Neuropeptides as regulators of airway function: vasoactive intestinal peptide and the tachykinins. Physiol Rev 1995; 75: 277-322.
4. Bertrand C, Geppetti P, Baker J, Yamawaki I, Nadel JA. Role of neurogenic inflammation in antigen-induced vascular extravasation in guinea pig trachea. J Immunol 1993; 150: 1479-85.
5. Zhang WP, Lu ZY, Wei EQ. Effects of tachykinin receptor antagonists on allergic asthma in guinea pigs. Acta Pharm Sin 1997; 32: in press.
6. Ricciardolo FLM, Nadel JA, Graf PD, Bertrand C, Yoshihara S, Geppetti P. Role of kinins in anaphylactic-induced bronchoconstriction mediated by tachykinins in guinea-pigs. Br J Pharmacol 1991; 113: 508-12.
7. 4, and substance P from guinea pig lungs. Am J Physiol 1991; 261 (6 Pt 1): L449-55.
8. Saria A, Martling C-R, Yan Z, Theodorsson-Norheim E, Gamse R, Lundberg JM. Release of multiple tachykinins from capsaicin-sensitive sensory nerves in the lung by bradykinin, histamine, dimethylphenyl piperazinium, and vagal nerve stimulation. Am Rev Respir Dis 1988; 137: 1330-5.
9. 1 receptor antagonist. Eur J Pharmacol 1993; 250: 403-13.
10. Regoli D, Boudon A, Fauchere JL. Receptors and antagonists for substance P and related peptides. Pharmacol Rev 1994; 46: 551-99.
11. Karol MH, Hillebrand JA, Thorne PS. Characteristics of weekly pulmonary hypersensitivity responses elicited in the guinea pig by inhalation of ovalbumin aerosols. Toxicol Appl Pharmacol 1989; 100: 234-46.
12. Kips JC, Cuvelier CA, Pauwels RA. Effect of acute and chronic antigen inhalation on airway morphology and responsiveness in actively sensitized rats. Am Rev Respir Dis 1992; 145: 1306-10.
13. Tallarida RJ, Murray RB. Manual of pharmacologic calculations. 1st ed. New York: Springer; 1981. p 14-9.
14. Joos GF, Kips JC, Pauwels RA. In vivo characterization of the tachykinin receptors involved in the direct and indirect bronchoconstrictor effect of tachykinins in two inbred rat strains. Am J Respir Crit Care Med 1994; 149: 1160-6.
15. Joos GF, Pauwels RA, Van der Straeten ME. The mechanism of tachykinin-induced bronchoconstriction in the rat. Am Rev Respir Dis 1988; 137: 1038-44.