Melatonin: A sleep-promoting hormone

Sleep

Volumn 20, Issue 10, 1997, Pages 899-907

  Zhdanova, Irina V ^a   Lynch, Harry J ^a   Wurtman, Richard J ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Circadian; Human; Melatonin; Sleep

Indexed keywords

MELATONIN; PLACEBO;

ADULT; CHILD; CIRCADIAN RHYTHM; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; HORMONAL REGULATION; HUMAN; INSOMNIA; INTRANASAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; JET LAG; ORAL DRUG ADMINISTRATION; PINEAL GLAND FUNCTION; PRIORITY JOURNAL; REVIEW; SLEEP DISORDER; SLEEP WAKING CYCLE; TREATMENT OUTCOME;

ADULT; AGED; CHILD; CHILD, PRESCHOOL; CIRCADIAN RHYTHM; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; HYPNOTICS AND SEDATIVES; MELATONIN; MIDDLE AGED; SLEEP DISORDERS;

EID: 0030784666     PISSN: 01618105     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (69)

1. McCord CP, Allen FP. Evidences associating pineal gland function with alterations in pigmentation. J Exp Zool 1917;23:207-24.
2. Lerner AB, Case JD, Heinzelman RV. Structure of melatonin. J Am Chem Soc 1959;81:6084-7.
3. Axelrod J, Weisbach H. Purification and properties of hydroxyindole-O-methyltransferase. J Biol Chem 1961;236:211-3.
4. Wurtman RJ, Axelrod J, Chu W. Melatonin, a pineal substance: effect on rat ovary. Science 1963;141:277-8.
5. Axelrod J, Wurtman RJ, Snyder SH. Control of hydroxyindole-O-methyl-transferase activity in the rat pineal by environmental light. J Biol Chem 1965;240:949-54.
6. Wurtman RJ, Axelrod J, Phillips LS. Melatonin synthesis in the pineal gland: control by light. Science 1963;142:1071-3.
7. Wurtman RJ, Axelrod J, Fisher JE. Melatonin synthesis in the pineal gland: effect of light mediated by the sympathetic nervous system. Science 1964;143:1328-30.
8. Kopin IJ, Pare MB, Axelrod J, Weisbach H. The fate of melatonin in animals. J Biol Chem 1961;236:3072-5.
9. Lynch HJ, Wurtman RJ, Moskowitz MA, Archer MC, Ho MH. Daily rhythm in human urinary melatonin. Science 1975;187: 169-71.
10. Czeisler CA, Shanahan TL, Klerman EB, et al. Suppression of melatonin secretion in some blind patients by exposure to bright light. N Engl J Med 1995;332(1):6-11.
11. Lewy AJ, Wehr T, Goodwin FK, Newsome DA, Markey SP. Light suppresses melatonin secretion in humans. Science 1980; 210:1267-9.
12. Kennaway DJ, Stamp GE, Goble FC. Development of melatonin production in infants and the impact of prematurity. J Clin Endocrinol Metab 1992;75(2):367-9.
13. Waldhauser F, Weiszenbacher G, Tatzer E, et al. Alterations in nocturnal serum melatonin levels in humans with growth and aging. J Clin Endocrinol Metab 1988;66:648-52.
14. Akerstedt T, Froberg JA, Friberg Y, Wetterberg L. Melatonin excretion, body temperature and subjective arousal during 64 hours of sleep deprivation. Psychoneuroendocrinology 1979;4: 219-25.
15. Zhdanova IV, Wurtman RJ, Morabito C, Piotrovska VR, Lynch HJ. Effects of low oral doses of melatonin, given 2-4 hours before habitual bedtime, on sleep in normal young humans. Sleep 1996;19(5):423-31.
16. Tzischinsky O, Shlitner A, Lavie P. The association between the nocturnal sleep gate and nocturnal onset of urinary 6-sulfatoxymelatonin. J Biol Rhythms 1993;8:199-209.
17. Haimov I, Laudon M, Zisapel N, et al. Sleep disorders and melatonin rhythms in elderly people. BMJ 1994;309:167.
18. Hajak G, Rodenbeck A, Staedt J, Bandelow B, Huether G, Ruther E. Nocturnal plasma melatonin levels in patients suffering from chronic primary insomnia. J Pineal Res 1995;19(3):116-22.
19. Lerner AB, Case JD. Melatonin. Fed Proc 1960;19:590-2.
20. Anton-Tay F, Diaz JL, Fernandez-Guardiola A. On the effect of melatonin upon human brain. Its possible therapeutic implications. Life Sci 1971;10:841-50.
21. Cramer H, Rudolph J, Consbruch U, Kendel K. On the effects of melatonin on sleep and behavior in man. Adv Biochem Psychopharmacol 1974;11:187-91.
22. Anton-Tay F. Melatonin: effects on brain function. In: Costa E, Gessa GL, Sandler M, eds. Serotonin - new vistas: biochemistry and behavioral and clinical studies. Advances in biochemical pharmacology, vol. 11. New York: Raven Press, 1974.
23. Lieberman HR, Waldhauser F, Garfield G, Lynch HJ, Wurtman RJ. Effects of melatonin on human mood and performance. Brain Res 1984;323:201-7.
24. Nickelsen T, Demisch L, Demisch K, Radermacher B, Schoffling K. Influence of subchronic intake of melatonin at various times of the day on fatigue and hormonal levels: a placebo-controlled, double-blind trial. J Pineal Res 1989;6:325-34.
25. Vollrath L, Semm P, Gammel G. Sleep induction by intranasal application of melatonin. Adv Biosci 1981;29:327-9.
26. Waldhauser F, Saletu B, Trinchard-Lugan I. Sleep laboratory investigations on hypnotic properties of melatonin. Psychopharmacology 1990;100:222-6.
27. Hughes RJ, Badia P, French KP, Santiago L, Plenzler S. Melatonin induced changes in body temperature and daytime sleep. J Sleep Res 1994; Suppl 1:111 (abstract).
28. Cajochen C, Krauchi K, Mori D, von Arx M, Wirz-Justice A. Melatonin increases sleepiness and theta activity in the wake EEG, but does not affect sleep EEG except to lengthen the first REM sleep episode. Soc Light Ther Biol Rhythms 1995;7:12 (abstract).
29. Dijk DJ, Roth C, Landolt HP, et al. Melatonin effect on daytime sleep in men: suppression of EEG low frequency activity and enhancement of spindle frequency activity. Neurosci Lett 1995; 1,201(1):13-6.
30. Tzischinski O, Lavie P. Melatonin processes time-dependent hypnotic effects. Sleep 1994;17:638-45.
31. Nave R, Peled R, Lavie P. Melatonin improves evening napping. Eur J Pharmacol 1995;275:213-6.
32. James SP, Mendelson WB, Sack DA, Rosenthal NE, Wehr TA. The effect of melatonin on normal sleep. Neuropsychopharmacology 1987;1:41-4.
33. James SP, Sack DA, Rosenthal NE, Mendelson WB. Melatonin administration in insomnia. Neuropsychopharmacology 1990;1: 19-23.
34. Ellis CM, Lemmens G, Parkes JD. Melatonin and insomnia. J Sleep Res 1996;5:61-5.
35. Dollins AB, Lynch HJ, Wurtman RJ, et al. Effect of pharmacological daytime doses of melatonin on human mood and performance. Psychopharmacology 1993;112:490-6.
36. Dollins AB, Zhdanova IV, Wurtman RJ, Lynch HJ, Deng MH. Effect of inducing nocturnal serum melatonin concentrations in daytime on sleep, mood, body temperature, and performance. Proc Natl Acad Sci USA 1994;91:1824-8.
37. Zhdanova IV, Wurtman RJ, Lynch HJ, et al. Sleep-inducing effects of low doses of melatonin ingested in the evening. Clin Pharmacol Ther 1995;57:552-8.
38. Jan JE, Espezel H, Appleton RE. The treatment of sleep disorders with melatonin. Dev Med Child Neurol 1994;36:97-107.
39. Zhdanova IV, Wagstaff J, Wurtman RJ. Melatonin and sleep in Angelman syndrome children. Presented at the 10th annual meeting of the APSS, Washington 1996:28 (abstract).
40. Zhdanova IV, Wurtman RJ, Balcioglu A, Lynch HJ. Endogenous and exogenous melatonin levels: age effects. Presented at the 11th annual meeting of the APSS, San Francisco, 1997:262 (abstract).
41. Garfinkel D, Laudon M, Nof D, Zisapel N. Improvement of sleep quality in elderly people by controlled-release melatonin. Lancet 1995;346(8,974):541-4.
42. Wurtman RJ, Zhdanova IV. Improvement of sleep quality by melatonin. Lancet 1995;346(8,988):1491.
43. Shibata S, Moore RY. Neuropeptide Y and optic chiasm stimulation affect suprachiasmatic nucleus circadian function in vitro. Brain Res 1993;615(1):95-100.
44. Shirakawa T, Moore RY. Responses of rat suprachiasmatic nucleus neurons to substance P and glutamate in vitro. Brain Res 1994;642:213-20.
45. Shirakawa T, Moore RY. Glutamate shifts the phase of the circadian neuronal firing rhythm in the rat suprachiasmatic nucleus in vitro. Neurosci Lett 1994;178(1):47-50.
46. McArthur AJ, Gillette MU, Prosser RA. Melatonin directly resets the rat suprachiasmatic circadian clock in vitro. Brain Res 1991;565(1):158-61.
47. Jiang ZG, Nelson CS, Allen CN. Melatonin activates an outward current and inhibits Ih in rat suprachiasmatic nucleus neurons. Brain Res 1995;687(1-2):125-32.
48. Shibata S, Cassone VM, Moore RY. Effects of melatonin on neuronal activity in the rat suprachiasmatic nucleus in vitro. Neurosci Lett 1989;97(1-2):140-4.
49. Mason R, Brooks A. The electrophysiological effects of melatonin and a putative melatonin antagonist (N-acetyltryptamine) on rat suprachiasmatic neurones in vitro. Neurosci Lett 1988; 95(1-3):296-301.
50. Stehle J, Vanecek J, Vollrath L. Effects of melatonin on spontaneous electrical activity of neurons in rat suprachiasmatic nuclei: an in vitro iontophoretic study. J Neural Transm 1989; 78(2):173-7.
51. Lewy AJ, Ahmed S, Jackson JM, Sack RL. Melatonin shifts human circadian rhythms according to a phase-response curve. Chronobiol Int 1992;9(5):380-92.
52. Lewy AJ, Sack RL. Use of melatonin to assess and treat circadian phase disorders. In Touitou Y, Arendt J, Pevet P eds. Melatonin and the pineal gland - from basic science to clinical application. Amsterdam: Excerpta Medica, 1993.
53. Zaidan R, Geoffriau M, Brun J, et al. Melatonin is able to influence its secretion in humans: description of a phase response curve. Neuroendocrinology 1994:60105-112.
54. Armstrong SM, Cassone VM, Chesworth MJ, Redman J, Short RV. Synchronization of mammalian circadian rhythms by melatonin. J Neural Transm 1986;21:375-94.
55. Redman J, Armstrong SM, Ng KT. Free-running activity rhythms in the rat: entrainment by melatonin. Science 1983;219: 1089.
56. Sugden D. Sedative potency and 2-[125]iodomelatonin binding affinity of melatonin analogues. Psychopharmacology 1995; 117:364-70.
57. Morgan PJ, Barrett P, Hazlerigg D, et al. Melatonin receptors couple through a cholera toxin-sensitive mechanism to inhibit cyclic AMP in the ovine pituitary. J Neuroendocrinol 1995;7(5): 361-9.
58. Webley GE, Luck MR. Melatonin directly stimulates the secretion of progesterone by human and bovine granulosa cells in vitro. J Reprod Fertil 1986;78(2):711-7.
59. Cardinali DP, Del Zar MM, Vacas MI. The effects of melatonin in human platelets. Acta Physiol Pharmacol Ther Latinoam 1993;43(1-2):1-13.
60. Puig-Domingo M, Webb SM, Serrano J, et al. Brief report: melatonin-related hypogonadotropic hypogonadism. N Engl J Med 1992;327(19):1356-9.
61. Berga SL, Mortola JF, Yen SS. Amplification of nocturnal melatonin secretion in women with functional hypothalamic amenorrhea. J Clin Endocrinol Metab 1988;66(1):242-4.
62. Heubner O. Tumor der glandula pinealis. Dtsch Med Wochenschr 1898;24:214.
63. Waldhauser F, Lieberman H, Lynch HJ, et al. A pharmacological dose of melatonin increases PRL levels in males without altering those of GH, LH, FSH, TSH, testosterone or cortisol. Neuroendocrinology 1987;46(2):125-30.
64. Cagnacci A, Elliott JA, Yen SS. Melatonin: a major regulator of the circadian rhythm of core temperature in humans. J Clin Endocrinol Metab 1992;75(2):447-52.
65. Middleton BA, Stone BM, Arendt J. Melatonin and fragmented sleep patterns. Lancet 1996;348(9026):551.
66. Arendt J, Borbely AA, Franey C, Wright J. The effects of chronic small doses of melatonin given in the late afternoon on fatigue in man: a preliminary study. Neurosci Lett 1984;45:317-21.
67. MacFarlane JG, Cleghorn JM, Brown GM, Streiner DL. The effects of exogenous melatonin on the total sleep time and daytime alertness of chronic insomniacs: a preliminary study. Biol Psychiatry 1991;30:371-6.
68. Dahlitz M, Alvarez B, Vignau J, English J, Arendt J, Parkes JD. Delayed sleep phase syndrome response to melatonin. Lancet 1991;11:1121-4.
69. Attenburrow MEJ, Sharpley AL, Cowen PJ. The acute effects of low dose melatonin on sleep. Presented at the meeting of the British Association for Psychopharmacology, King's College, Cambridge, U.K., 1995 (abstract).