Postinfarction use of β-blockers in elderly patients

Drugs and Aging

Volumn 11, Issue 6, 1997, Pages 424-432

  Aronow, Wilbert S ^a,b  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b HEBREW HOSPITAL HOME   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIANGINA PECTORIS AGENT; ANTIHYPERTENSIVE AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CARVEDILOL; METOPROLOL; NITRATE; PROPRANOLOL; TIMOLOL;

AGED; ANGINA PECTORIS; ARTERY DISEASE; ARTICLE; ASTHMA; ATRIOVENTRICULAR BLOCK; BRADYCARDIA; BRONCHOSPASM; CIRCADIAN RHYTHM; CLINICAL TRIAL; CONGESTIVE HEART FAILURE; DIABETES MELLITUS; DRUG MECHANISM; GANGRENE; HEART INFARCTION; HEART LEFT VENTRICLE EJECTION FRACTION; HEART MUSCLE ISCHEMIA; HEART VENTRICLE ARRHYTHMIA; HEART VENTRICLE FIBRILLATION; HUMAN; HYPERTENSION; HYPOTENSION; INTRAVENOUS DRUG ADMINISTRATION; LUNG DISEASE; MORTALITY; PRACTICE GUIDELINE; PRIORITY JOURNAL; SUDDEN DEATH; SYMPATHETIC TONE; TACHYCARDIA;

EID: 0030784513     PISSN: 1170229X     EISSN: None     Source Type: Journal    
DOI: 10.2165/00002512-199711060-00002     Document Type: Article

References (65)

1. Hjalmarson A, Herlitz J, Holmberg S, et al. The Göteborg Metoprolol Trial: effects on mortality and morbidity in acute myocardial infarction. Circulation 1983; 67 Suppl. I: 126-31
2. The Norwegian Multicentre Study Group. Timolol-induced reduction in mortality and reinfarction in patients surviving acute myocardial infarction. N Engl J Med 1981; 304: 801-7
3. Pedersen TR. The Norwegian Multicentre Study of Timolol after myocardial infarction. Circulation 1983; 67 Suppl. I: 149-52
4. Gundersen T, Abrahamsen AM, Kjekshus J, et al. Timolol-related reduction in mortality and reinfarction in patients aged 65-75 years surviving acute myocardial infarction. Circulation 1982; 66: 1179-84
5. Pedersen TR, for the Norwegian Multicentre Study Group. Six-year follow-up of the Norwegian Multicentre Study on Timolol after acute myocardial infarction. N Engl J Med 1985; 313: 1055-8
6. Beta-Blocker Heart Attack Trial Research Group. A randomized trial of propranolol in patients with acute myocardial infarction. JAMA 1982; 247: 1707-14
7. Hawkins CM, Richardson DW, Vokonas PS. Effect of propranolol in reducing mortality in older myocardial infarction patients: the Beta-Blocker Heart Attack Trial experience. Circulation 1983; 67 Suppl. I: 194-7
8. Park KC, Forman DE, Wei JY. Utility of beta-blockade treatment for older postinfarction patients. J Am Geriatr Soc 1995; 43: 751-5
9. Soumerai SB, McLaughlin TJ, Spiegelman D, et al. Adverse outcomes of underuse of beta-blockers in elderly survivors of acute myocardial infarction. JAMA 1997; 277: 115-21
10. Yusuf S, Wittes J, Probstfield J. Evaluating effects of treatment subgroups of patients within a clinical trial: the case of non-Q-wave myocardial infarction and beta blockers. Am J Cardiol 1990; 60: 220-2
11. Ryan TJ, Anderson JL, Antman EM, et al. ACC/AH A guidelines for the management of patients with acute myocardial infarction: executive summary. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on Management of Acute Myocardial Infarction). Circulation 1996; 94: 2341-50
12. Lichstein E, Morgenroth J, Harrist R, et al. Effect of propranolol on ventricular arrhythmia: the Beta-Blocker Heart Attack Trial experience. Circulation 1983; 67 Suppl. 1: 15-10
13. Hansteen V. Beta blockade after myocardial infarction: the Norwegian Propranolol Study in high-risk patients. Circulation 1983; 67 Suppl. I: 157-60
14. Aronow WS, Ahn C, Mercando AD, et al. Effect of propranolol versus no antiarrhythmic drug on sudden cardiac death, total cardiac death, and total death in patients ≥62 years of age with heart disease, complex ventricular arrhythmias, and left ventricular ejection fraction ≥40%. Am J Cardiol 1994; 74: 267-70
15. Aronow WS, Ahn C, Mercando AD, et al. Decrease of mortality by propranolol in patients with heart disease and complex ventricular arrhythmias is more an anti-ischemic than an antiarrhythmic effect. Am J Cardiol 1994; 74: 613-5
16. Norris RM, Barnaby PF, Brown MA, et al. Prevention of ventricular fibrillation during acute myocardial infarction by intravenous propranolol. Lancet 1984; II: 883-6
17. Stone PH, Gibson RS, Glasser SP, et al. Comparison of propranolol, diltiazem, and nifedipine in the treatment of ambulatory ischemia in patients with stable angina. Differential effects on ambulatory ischemia, exercise performance, and anginal symptoms. Circulation 1990; 82: 1962-72
18. Imperi GA, Lambert CR, Coy K, et al. Effects of titrated beta blockade (metoprolol) on silent myocardial ischemia in ambulatory patients with coronary artery disease. Am J Cardiol 1987; 60: 519-24
19. Benhorin J, Banai S, Moriel M, et al. Circadian variations in ischemic threshold and their relation to the occurrence of ischemic episodes. Circulation 1993; 87: 808-14
20. Aronow WS, Ahn C, Mercando AD, et al. Effect of propranolol on circadian variation of ventricular arrhythmias in elderly patients with heart disease and complex ventricular arrhythmias. Am J Cardiol 1995; 75: 514-6
21. Aronow WS, Ahn C, Mercando AD, et al. Effect of propranolol on circadian variation of myocardial ischemia in elderly patients with heart disease and complex ventricular arrhythmias. Am J Cardiol 1995; 75: 837-9
22. Kurien V, Oliver MF. Serum-free-fatty-acids after acute myocardial infarction and cerebral vascular occlusion. Lancet 1966; II: 122-7
23. Muller JE, Stone PH, Turi ZG, et al. Circadian variation in the frequency of onset of acute myocardial infarction. N Engl J Med 1985; 313: 1315-22
24. Willich SN, Levy D, Rocco MB, et al. Circadian variation in the incidence of sudden cardiac death in the Framingham Heart Study population. Am J Cardiol 1987; 60: 801-6
25. Levine RL, Pepe PE, Fromm Jr RE, et al. Prospective evidence of a circadian rhythm for out-of-hospital cardiac arrests. JAMA 1992; 367: 2935-7
26. Aronow WS, Ahn C. Circadian variation of primary cardiac arrest or sudden cardiac death in patients aged 62 to 100 years (mean 82). Am J Cardiol 1993; 71: 1455-6
27. Aronow WS, Ahn C, Mercando AD, et al. Circadian variation of sudden cardiac death or fatal myocardial infarction is abolished by propranolol in patients with heart disease and complex ventricular arrhythmias. Am J Cardiol 1994; 74: 819-21
28. Friedman LM, Byington RP, Capone RJ, et al. Effect of propranolol in patients with myocardial infarction and ventricular arrhythmia. J Am Coll Cardiol 1986; 7: 1-8
29. Kennedy HL, Brooks MM, Barker AH, et al. Beta-blocker therapy in the Cardiac Arrhythmia Suppression Trial. Am J Cardiol 1994; 74: 674-80
30. Hallstrom AP, Cobb LA, Hui Yu B, et al. An antiarrhythmic drug experience in 941 patients resuscitated from an initial cardiac arrest between 1970 and 1985. Am J Cardiol 1991; 68: 1025-31
31. Amsterdam EA, Gorlin R, Wolfson S. Evaluation of long-term use of propranolol in angina pectoris. JAMA 1969; 210: 103-6
32. Thadani U, Parker JO. Propranolol in the treatment of angina pectoris: comparison of duration of action in acute and sustained oral therapy. Circulation 1979; 59: 571-9
33. Aronow WS, Turbow M, Van Camp S, et al. The effect of timolol versus placebo on angina pectoris. Circulation 1980; 61: 66-9
34. Frishman WH, Sonnenblick EH. Beta-adrenergic blocking drugs. In: Schlant RC, Alexander RW, editors. The heart. 8th ed. New York: McGraw-Hill, 1994: 1271-90
35. Amery A, Birkenhager W, Brixko P, et al. Mortality and morbidity results from the European Working Party on Hypertension in Elderly Trial. Lancet 1985; 1: 1349-54
36. Dahlof B, Lindholm LH, Hansson L, et al. Morbidity and mortality in the Swedish Trial in Old Patients With Hypertension (STOP Hypertension). Lancet 1991; 338: 1281-5
37. MRC Working Party. Medical Research Council Trial of treatment of hypertension in older adults: principal results. BMJ 1992; 304: 405-12
38. SHEP Cooperative Research Group. Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension: final results of the Systolic Hypertension in the Elderly Program (SHEP). JAMA 1991; 265: 3255-64
39. 1993 Joint National Committee. The Fifth Report of the Joint National Committee on the Detection, Evaluation, and Treatment of High Blood Pressure (JNCV). Arch Intern Med 1993; 153: 154-83
40. Vokonas PS, Kannel WB. Epidemiology of coronary heart disease in the elderly. In: Tresch DD, Aronow WS, editors. Cardiovascular disease in the elderly patient. New York: Marcel Dekker, 1994: 91-123
41. Aronow WS, Ahn C. Risk factors for new coronary events in a large cohort of very elderly patients with and without coronary artery disease. Am J Cardiol 1996; 77: 864-6
42. Gundersen T, Kjekshus J. Timolol treatment after mycocardial infarction in diabetic patients. Diabetes Care 1983; 6: 285-90
43. Malmberg K, Ryden L. Myocardial infarction in patients with diabetes mellitus. Eur Heart J 1988; 9: 259-64
44. Malmberg K, Herlitz J, Hjalmarson A, et al. Effects of metoprolol on mortality and late infarction in diabetics with suspected acute myocardial infarction: retrospective data from two large studies. Eur Heart J 1989; 10: 423-8
45. Kjekshus J, Gilpin E, Blackey AR, et al. Diabetic patients and beta-blockers after acute myocardial infarction. Eur Heart J 1990; 11: 43-50
46. Jonas M, Reicher-Reiss H, Boyko V, et al. Usefulness of beta-blocker therapy in patients with non-insulin-dependent diabetes mellitus and coronary artery disease. Am J Cardiol 1996; 77: 1273-7
47. Shorr RI, Ray WA, Daugherty JR, et al. Antihypertensives and the risk of serious hypoglycemia in older persons using insulin or sulfonylureas. JAMA 1997; 278: 40-3
48. Chadda K, Goldstein S, Byington R, et al. Effect of propranolol after acute myocardial infarction in patients with congestive heart failure. Circulation 1986; 73: 503-10
49. The Beta-Blocker Pooling Project Research Group. The Beta-Blocker Pooling Project (BBPP): subgroup findings from randomised trials in post-infarction patients. Eur Heart J 1988; 9: 8-16
50. Packer M, Bristow MR, Conn JN, et al. The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. N Engl J Med 1996; 334: 1349-55
51. Aronow WS, Ahn C, Kronzon I. Effect of propranolol versus no propranolol on total mortality plus nonfatal myocardial infarction in older patients with prior myocardial infarction, congestive heart failure, and left ventricular ejection fraction ≥40% treated with diuretics plus angiotensin-converting-enzyme inhibitors. Am J Cardiol 1997; 80: 207-9
52. Lichstein E, Hager WD, Gregory JJ, et al. Relation between beta-adrenergic blocker use, various correlales of left ventricular function and the chance of developing congestive heart failure. J Am Coll Cardiol 1990; 16: 1327-32
53. Wong WF, Gold S, Fukuyama O, et al. Diastolic dysfunction in elderly patients with congestive heart failure. Am J Cardiol 1989; 63: 1526-8
54. Aronow WS, Ahn C, Kronzon I. Prognosis of congestive heart failure in elderly patients with normal versus abnormal left ventricular systolic function associated with coronary artery disease. Am J Cardiol 1990; 66: 1257-9
55. Pfeffer MA, Braunwald E, Move LA, et al. Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction: results of the Survival and Ventricular Enlargement Trial. N Engl J Med 1992; 327: 669-77
56. Vantrimpont P, Rouleau JL, Wun C-C, et al. Additive beneficial effects of beta-blockers to angiotensin-converting enzyme inhibitors in the Survival and Ventricular Enlargement (SAVE) Study. J Am Coll Cardiol 1997; 29: 229-36
57. Radack K, Deck C. Beta-adrenergic blocker therapy does not worsen intermittent claudication in subjects with peripheral arterial disease: a meta-analysis of randomized controlled trials. Arch Intern Med 1991; 151: 1769-76
58. Forman DE, Wei JY. Beta-blockade in older patients with myocardial infarction [letter]. JAMA 1991; 266: 2222
59. Gurwitz JM, Goldberg RJ, Chen Z, et al. Beta-blocker therapy in acute myocardial infarction; evidence for underutilization in the elderly. Am J Med 1992; 93: 605-10
60. Rich MW, Bosner MS, Chung MK, et al. Is age an independent predictor of early and late mortality in patients with acute myocardial infarction. Am J Med 1992; 92: 7-13
61. Montague TJ, Ikuta RM, Wong RY, et al. Comparison of risk and patterns of practice in patients older and younger than 70 years with acute myocardial infarction in a two year period (1987-1989). Am J Cardiol 1991; 68: 843-7
62. Karlson BW, Herlitz J, Hjalmarson A. Impact of clinical trials on the use of beta blockers after acute myocardial infarction and its relation to other risk indicators for death and 1-year mortality rate. Clin Cardiol 1994; 17: 311-6
63. Aronow WS. Prevalence of use of beta blockers and of calcium channel blockers in older patients with prior myocardial infarction at the time of admission to a nursing home. J Am Geriatr Soc 1996; 44: 1075-7
64. Fishkind D, Paris BEC, Aronow WS. Use of digoxin, diuretics, beta blockers, angiotensin-converting-enzyme inhibitors, and calcium channel blockers in older patients in an academic hospital-based geriatrics practice. J Am Geriatr Soc 1997; 45: 809-12
65. Mendelson G, Aronow WS. Underulilization of beta blockers in older patients with prior myocardial infarction or coronary artery disease in an academic hospital-based geriatrics practice. J Am Geriatr Soc. 1997; 45: 1361-2