Amino acid nucleic acids: Synthesis and hybridization properties of a novel class of antisense oligonucleotides

Nucleosides and Nucleotides

Volumn 16, Issue 7-9, 1997, Pages 1519-1522

  Ramasamy, Kanda S ^a   Seifert, Wilfried ^a  

^a Valeant Pharmaceuticals International   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID DERIVATIVE; AMINO ACID; ANTISENSE OLIGONUCLEOTIDE; DEXTRO SERINE; EXONUCLEASE; NUCLEIC ACID; NUCLEOSIDE ANALOG; PHOSPHORAMIDIC ACID; POLYTHYMIDYLIC ACID; THYMIDINE DERIVATIVE; TRIFLUOROACETIC ACID;

CONFERENCE PAPER; DNA SYNTHESIS; DRUG SYNTHESIS; HYDROGEN BOND; NUCLEIC ACID HYBRIDIZATION; NUCLEIC ACID SYNTHESIS; NUCLEOTIDE METABOLISM; NUCLEOTIDE SEQUENCE; STEREOCHEMISTRY;

EID: 0030784512     PISSN: 07328311     EISSN: None     Source Type: Journal    
DOI: 10.1080/07328319708006220     Document Type: Conference Paper

References (13)

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2. (b) Goodchild, J. Bioconjugate Chem. 1990, 1, 165.
3. Ramasamy, K.; Seifert, W. Bioorg. & Med. Chem. Lett., 1996, 6, 1799 and references cited there in.
4. Nucleobases attached to serinol via acetamide linker. See Fig. 1 and structure (2).
5. Egholm, M.; Buchardt, O.; Nielsen, P. E.; Berg, R. H. J. Am. Chem. Soc. 1992, 114, 1895.
6. Ramasamy, K.; Olsen, R. K.; Emery, T. Synthesis 1982, 42.
7. 1HNMR and elemental analysis.
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9. Karpyshev, N. N. Russ. Chem. Rev. 1988, 57, 886.
10. Atkinson, T.; Smith, M. in Oligonucleotide Synthesis: A practical Approach; Gait, M. J., Ed.; IRL: Oxford; 1984; pp 35-81.
11. Oligonucleotides were digested with a mixture of spleen phosphodiesterase, snake venom phosphodiesterase, and bacterial alkaline phosphatase to provide individual nucleosides which were analyzed by HPLC.
12. Freier, S. M.; Albergo, D. D.; Turner, D. H. Biopolymers 1982, 22, 1107.
13. For experimental procedure see: Svendsen, M. L.; Wengel, J. Tetrahedron 1993, 49, 11341.