Absence of detectable toxicity in rats fed partially hydrolyzed guar gum (K-13) for 13 weeks

International Journal of Toxicology

Volumn 16, Issue 6, 1997, Pages 611-623

  Koujitani, Takatoshi ^a   Oishi, Hidetoshi ^a   Kubo, Yuji ^a   Maeda, Toshihiro ^a   Sekiya, Keiji ^a   Yasuba, Masashi ^a   Matsuoka, Nobuo ^a   Nishimura, Koichi ^a  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

Author keywords

Acute toxicity study; Mutagenicity study; Partially hydrolyzed guar gum; Subchronic toxicity study

Indexed keywords

GUAR GUM;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC TOXICITY; CONTROLLED STUDY; ESCHERICHIA COLI; FEMALE; HYDROLYSIS; MALE; MOUSE; MUTAGENICITY; NONHUMAN; RAT; REVERTANT; SALMONELLA TYPHIMURIUM; TOXICITY TESTING;

ANIMALIA; CYAMOPSIS TETRAGONOLOBA; ESCHERICHIA COLI; SALMONELLA TYPHIMURIUM; TYPHIMURIUM;

EID: 0030783713     PISSN: 10915818     EISSN: None     Source Type: Journal    
DOI: 10.1080/109158197226928     Document Type: Article

References (8)

1. Ames, B. N., McCann, J., and Yamasaki, E. 1975. Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. Mutat. Res. 31:347-364.
2. Graham, S. L., Arnold, A., Kasza, L., Ruffin, G. E., Jackson, R. C., Watkins, T. L., and Graham, C. H. 1981. Subchronic effects of guar gum in rats. Food Cosmet. Toxicol. 19:287-290.
3. Lairon, D. 1996. Dietary fibres: Effects on lipid metabolism and mechanisms of action. Eur. J. Clin. Nutr. 50:125-133.
4. Takahashi, H., Yang, S. I., Fujiki, M., Kim, M., Yamamoto, T, and Greenberg, N. A. 1994. Toxicity studies of partially hydrolyzed guar gum. J. Am. Coll. Toxicol. 13:273-278.
5. Takeno, F., Yamada, H., Sekiya, K., Fujitani, B., and Ohtsu, K 1990. Effect of partially decomposed guar gum on high-cholesterol-fed rats and non-dietary fiber-fed rats. J. Jpn. Soc. Nutr. Food Sci. 43:421-425.
6. Yamatoya, K. 1994. Hydrolysed guar gum. A new generation water-soluble dietary fibre. Int. Food Ingr. 4:15-19.
7. Yamatoya, K., Sekiya, K., Yamada, H., and Ichikawa, T. 1993. Effects of partially hydrolyzed guar gum on postprandial plasma glucose and lipid levels in humans. J. Jpn. Soc. Nutr. Food Sci. 46:199-203.
8. Yamatoya, K., Kuwano, K., Suzuki, J., Mitamura, T., and Sekiya, K. 1995. Effect of hydrolyzed guar gum on frequency and feeling of defecation in humans. J. Appl. Glycosci. 42(3):251-257.