Role of heat shock proteins in MPTP-induced neurotoxicity

Annals of the New York Academy of Sciences

Volumn 825, Issue , 1997, Pages 167-178

  Freyaldenhoven, Tim E ^b   Ali, Syed F ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; DOPAMINE; HEAT SHOCK PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BLOOD BRAIN BARRIER; BODY TEMPERATURE; CELL CULTURE; CHO CELL; CONFERENCE PAPER; CONTROLLED STUDY; CORPUS STRIATUM; CYTOTOXICITY; HYPERTHERMIA; MALE; MOUSE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PROTEIN INDUCTION; THERMOREGULATION;

ANIMALIA;

EID: 0030783663     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1997.tb48427.x     Document Type: Conference Paper

References (50)

1. BURNS, R. S., C. C. CHIUEH, S. P. MARKEY, M. H. EBERT, D. M. JACOBOWITZ & I. J. KOPIN. 1983. A primate model of Parkinsonism: selective destruction of dopaminergic neurons in pars compacta of the substantia nigra by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Proc. Natl. Acad. Sci. USA 80: 4546-4550.
2. DAVIS, G. C., A. C. WILLIAMS, S. P. MARKEY, M. H. EBERT, E. D. CAINE, C. M. REIHERT & I. J. KOPIN. 1979. Chronic Parkinsonism secondary to intravenous injection of meperidine analogs. Psychiatry Res. 1: 249-254.
3. HEIKKILA, R. E., A. HESS & R. D. DUVOISIN. 1984. Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice. Science 224: 1451-1453.
4. LANGSTON, J. W., P. BALLARD, J. W. TETRUD & I. IRWIN. 1983. Chronic Parkinsonism in humans due to a product of meperidine analog synthesis, Science 219: 979-980.
5. HEIKKILA, R. E., L. MANZINO, F. S. CABBAT & R. C. DUVOISIN. 1984. Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by monoamine oxidase inhibitors. Nature 311: 467-469.
6. +: identification of a metabolite of MPTP, a toxin selective to the substantia nigra. Neurosci. Lett. 48: 87-92.
7. JAVITCH, J. A., R. J. D'AMATO, S. M. STRITTMATTER & S. H. SNYDER. 1985. Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity, Proc. Natl. Acad. Sci. USA 82: 2173-2177.
8. LIU, Y., A. ROGHANI & R. H. EDWARDS. 1992. Gene transfer of a reserpine-sensitive mechanism of resistance to N-methyl-4-phenylpyridinium. Proc. Natl. Acad. Sci. USA 89: 9074-9078.
9. REINHARD, J. F., E. J. DILIBERTO, JR., O. H. VIVEROS & A. J. DANIELS. 1987. Subcellular compartmentalization of 1-methyl-4-phenylpyridinium with catecholamines in adrenal medullary chromaffin vesicles may explain the lack of toxicity to adrenal chromaffin cells. Proc. Natl. Acad. Sci., USA 84: 8160-8164.
10. + cause rapid ATP depletion in isolated hepatocytes. Biochem. Biophys. Res. Commun. 137: 310-315.
11. +) cytotoxicity. Biochem. Biophys. Res. Commun. 137: 303-309.
12. RAMSAY, R. R. & T. P. SINGER. 1986. Energy-dependent uptake of N-methyl-4-phenylpyridinium, the neurotoxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, by mitochondria, J. Biol. Chem. 261: 7585-7587.
13. NIKLAS, W. J., I. VYAS & R. E. HEIKKILA. 1985. Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Life Sci. 36: 2503-2508.
14. +-induced neurotoxicity in mouse is age-dependent: evidenced by the selective inhibition of complexes of electron transport. Brain Res. 715: 1-8.
15. CHAN, P., L. E. DELANNEY, I. IRWIN, J. W. LANGSTON & D. DIMONTE. 1991. Rapid ATP loss caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mouse brain. J. Neurochem. 57: 348-351.
16. CHAN, P., J. W. LANGSTON, I. IRWIN, L. E. DELANNEY & D. A. DIMONTE. 1993. 2-Deoxyglucose enhances 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced ATP loss in the mouse brain. J. Neurochem. 61: 610-616.
17. SCOTCHER, K. P., I. IRWIN, L. E. DELANNEY, J. W. LANGSTON & D. DIMONTE. 1990. Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 1-methyl-4-phenylpyridinium ion on ATP levels of mouse brain synaptosomes. J. Neurochem. 54: 1295-1301.
18. HALLMAN, H., J. LANGE, L. OLSON, I. STROMBERG & G. JONSSON. 1985. Neurochemical and histochemical characterization of neurotoxic effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on brain catecholamine neurons in the mouse. J. Neurochem. 44: 117-127.
19. + induced oxygen radical formation with mitochondrial enzymes. Free Radical Biol. Med. 15: 181-186.
20. ALI, S. F., S. N. DAVID, G. D. NEWPORT, J. L. CADET & W. SLIKKER, JR. 1994. MPTP-induced oxidative stress and neurotoxicity are age-dependent: evidence from measures of reactive oxygen species and striatal dopamine levels, Synapse 18: 27-34.
21. +. Free Radical Biol. Med. 13: 581-583.
22. CHIUEH, C. C., H. MIYAKE & M. PENG. 1993. Role of dopamine autoxidation, hydroxyl radical generation, and calcium overload in underlying mechanisms involved in MPTP-induced Parkinsonism. Adv. Neurol. 60: 251-258.
23. PRZEDBORSKI, S., V. KOSTIC, V. JACKSON-LEWIS, A. B. NAINI, S. SIMONETTI, S. FAHN, E. CARLSON, C. J. EPSTEIN & J. L. CADET. 1992. Transgenic mice with increased Cu/ Zn-superoxide dismutase activity are resistant to MPTP-induced neurotoxicity. J. Neurosci. 12: 1658-1667.
24. +) nigral toxicity in the rat by prior decortication of MK-801 treatment: a stereological estimate of neuronal loss. Neurobiol. Aging 14: 295-301.
25. TABATABAEI, A., T. L. PERRY, S. HANSEN & C. KRIEGER. 1992. Partial protective effect of MK-801 on MPTP-induced reduction of striatal dopamine in mice. Neurosci. Lett. 141: 192-194.
26. + neurotoxicity by N-methyl-D-aspartate antagonists. Nature 349: 414-418.
27. LINDQUIST, S. & E. A. CRAIG. 1988. The heat shock proteins. Annu. Rev. Genet. 22: 631-677.
28. TISSIERES, A., H. K. MITCHELL & U. M. TRACY. 1974. Protein synthesis in salivary glands of Drosophila melanogaster. J. Mol. Biol. 84: 389-398.
29. BURDON, R. H. 1993. Heat shock proteins in relation to medicine. Mol. Aspects Med. 14: 83-165.
30. WELCH, W. J. 1992. Mammalian stress response: cell physiology, structure/function of stress proteins, and implications for medicine and disease. Physiol. Rev. 72: 1063-1081.
31. DONATI, Y. R., D. O. SLOSMAN & B. S. POLLA. 1990. Oxidative injury and the heat shock response. Biochem. Pharmacol. 40: 2571-2577.
32. GABAI, V. L. & A. E. KABAKOV. 1993. Rise in heat-shock protein level confers tolerance to energy deprivation. FEBS Lett. 327: 247-250.
33. LOWENSTEIN, D. H., P. H. CHAN & M. F. MILES. 1991. The stress protein response in cultured neurons: characterization and evidence for a protective role in excitotoxicity. Neuron 7: 1053-1060.
34. SANDERS WILLIAMS, R., J. A. THOMAS, M. FINA, Z. GERMAN & I. J. BENJAMIN. 1993. Human heat shock protein 70 (hsp70) protects murine cells from injury during metabolic stress. J. Clin. Invest. 92: 503-508.
35. RIACHI, N. J., J. C. LAMANNA & S. I. HARIK. 1989. Entry of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine into the rat brain. J. Pharmacol. Exp. Ther. 249: 744-748.
36. KALARIA, R. N., M. J. MITCHELL & S. I. HARIK. 1987. Correlation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity with blood-brain barrier monoamine oxidase activity. Proc. Natl. Acad. Sci. USA 84: 3521-3525.
37. POLLA, B. S. & J. V. BONVENTRE. 1987. Heat shock protects from uncoupling of oxidative phosphorylation. Clin. Res. 35: 555A.
38. KOROSHETZ, W. J. & J. V. BONVENTRE. 1994. Heat shock response in the central nervous system. Experientia 50: 1085-1091.
39. FARGNOLI, J., T. KUNISADA, A. J. FORNACE, E. L. SCHNEIDER & N. J. HOLBROOK. 1990. Decreased expression of Hsp-70 mRNA and protein after heat treatment in cells of aged rats. Proc. Natl. Acad. Sci. USA 87: 846-850.
40. +-induced effects on body temperature exhibit age- and strain-dependence in mice. Brain Res. 688: 161-170.
41. +. Brain Res. 735: 42-49.
42. LI, G. C., L. LI, R. Y. LIU, M. REHMAN & W. M. F. LEE. 1992. Heat shock protein hsp70 protects cells from thermal stress even after deletion of its ATP-binding domain. Proc. Natl. Acad. Sci. USA 89: 2036-2040.
43. MOLDEUS, P., J. HOGBERG & S. ORRENIUS. 1978. Isolation and use of liver cells. Methods Enzymol. 52: 60-72.
44. LAEMMLI, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227: 680-685.
45. FREYALDENHOVEN, T. E., S. F. ALI & L. C. SCHMUED. 1997. Systemic administration of MPTP induces thalamic neuronal degeneration in mice. Brain Res. In press.
46. GETCHELL, T. V., N. S. R. KRISHNA, N. DHOOPER, D. L. SPARKS & M. L. GETCHELL. 1995. Human olfactory receptor neurons express heat shock protein 70: age-related trends. Ann. Otol. Rhinol. Laryngol. 104: 47-56.
47. PARDUE, S., K. GROSHAN, J. D. RAESE & M. MORRISON-BOGORAD. 1992. Hsp-70 mRNA induction is reduced in neurons of aged rat hippocampus after thermal stress. Neurobiol. Aging 13: 661-672.
48. ALI, S. F., S. N. DAVID, & G. D. NEWPORT. 1993. Age-related susceptibility to MPTP-induced neurotoxicity in mice. Neurotoxicology 14: 29-34.
49. IRWIN, I., K. T. FINNEGAN, L. E. DELANNEY, D. DIMONTE & J. W. LANGSTON. 1992. The relationship between aging, monoamine oxidase, striatal dopamine and the effects of MPTP in C57BL/6 mice: a critical reassessment. Brain Res. 572: 224-231.
50. PELHAM, H. R. B. 1986. Speculations on the functions of the major heat shock and glucose-regulated proteins. Cell 46: 959-961.