Identification of differentially expressed genes in chemically induced skin tumors

Molecular Carcinogenesis

Volumn 20, Issue 1, 1997, Pages 88-98

  Rutberg, Susan E ^a   Lee, Edwin J ^a   Hansen, Laura H ^a   Glick, Adam B ^a   Yuspa, Stuart H ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

AP 1 regulation; bcl 2; Differential display; Skin carcinogenesis

Indexed keywords

COMPLEMENTARY DNA; DNA; PROTEIN BCL 2; RNA; TRANSCRIPTION FACTOR AP 1; VIRUS DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; CHEMICAL CARCINOGENESIS; CONFERENCE PAPER; CONTROLLED STUDY; FEMALE; GENE EXPRESSION REGULATION; IN SITU HYBRIDIZATION; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; ONCOGENE C FOS; ONCOGENE C JUN; PRIORITY JOURNAL; RETROVIRUS; SEQUENCE HOMOLOGY; SKIN PAPILLOMA; SKIN TUMOR; SQUAMOUS CELL CARCINOMA; TUMOR SUPPRESSOR GENE;

ANIMALS; CARCINOMA; CELL LINE; DNA, NEOPLASM; DNA, VIRAL; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, FOS; GENES, JUN; HUMANS; KERATINOCYTES; MICE; MICE, INBRED SENCAR; PAPILLOMA; RISK FACTORS; SKIN NEOPLASMS; TRANSCRIPTION FACTOR AP-1;

ANIMALIA; UNIDENTIFIED RETROVIRUS;

EID: 0030783657     PISSN: 08991987     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2744(199709)20:1<88::AID-MC10>3.0.CO;2-5     Document Type: Conference Paper

References (61)

1. Yuspa SH. The pathogenesis of squamous cell cancer: Lessons learned from studies of skin carcinogenesis - Thirty-third G.H.A. Clowes Memorial Award Lecture. Cancer Res 54:1178-1189, 1994.
2. Slaga TJ. Cellular and molecular mechanisms involved in multi-stage skin carcinogenesis. In: Conti CJ, Slaga TJ, Klein-Szanto AJP (eds), Carcinogenesis. Raven Press, New York, 1989, pp. 1-18.
3. Domann FE, Jr., Levy JP, Finch JS, Bowden GT. Constitutive AP-1 DNA binding and transactivating ability of malignant but not benign mouse epidermal cells. Mol Carcinog 9:61-66, 1994.
4. Domann FE, Levy JP, Birrer MJ, Bowden GT. Stable expression of a c-JUN deletion mutant in two malignant mouse epidermal cell lines blocks tumor formation in nude mice. Cell Growth Differ 5:9-16, 1994.
5. Dong Z, Birrer MJ, Watts RG, Matrisian LM, Colburn NH. Blocking of tumor promoter-induced AP-1 activity inhibits induced transformation in JB6 mouse epidermal cells. Proc Natl Acad Sci USA 91:609-613, 1994.
6. Dong Z, Lavrovsky V, Colburn NH. Transformation reversion induced in JB6 RT101 cells by AP-1 inhibitors. Carcinogenesis 16:749-756, 1995.
7. Greenhalgh DA, Welty DJ, Player A, Yuspa SH. Two oncogenes, v-fos and v-ras, cooperate to convert normal keratinocytes to squamous cell carcinomas. Proc Natl Acad Sci USA 87:643-647, 1990.
8. Greenhalgh DA, Yuspa SH. Malignant conversion of murine squamous papilloma cell lines by transfection with the fos oncogene. Mol Carcinog 1:134-143, 1988.
9. Saez E, Rutberg SE, Mueller E, et al. c-fos is required for malignant progression of skin tumors. Cell 82:721-732, 1995.
10. Ha induces autonomous papillomas in transgenic epidermis but not malignant conversion. Cancer Res 53:5071-5075, 1993.
11. Ha-activated papillomas and carcinomas without p53 mutation: Association of v-fos expression with promotion and tumor autonomy. Cell Growth Differ 6:579-586, 1995.
12. Tsang TC, Chu YW, Hendrix MJC, Bowden GT. v-jun oncogene suppresses both phorbol ester induced cell invasion and stromelysin gene expression in a mouse papilloma cell line. Cancer Res 54:882-886, 1994.
13. Ha oncogene and form papillomas in skin grafts on athymic nude mouse hosts. Cancer Res 48:165-169, 1988.
14. Hennings H, Michael D, Cheng C, Steinert P, Holbrook K, Yuspa SH. Calcium regulation of growth and differentiation of mouse epidermal cells in culture. Cell 19:245-254, 1980.
15. Roop DR, Lowy DR, Tambourin PE, et al. An activated Harvey ras oncogene produces benign tumors on mouse epidermal tissue. Nature 323:822-824, 1986.
16. Yuspa SH, Hawley-Nelson P, Koehler B, Stanley JR. A survey of transformation markers in differentiating epidermal cell lines in culture. Cancer Res 40:4694-4703, 1980.
17. Tennenbaum T, Belanger AJ, Glick AB, Tamura R, Quaranta V, Yuspa SH. A splice variant of α6 integrin is associated with malignant conversion in mouse skin tumorigenesis. Proc Natl Acad Sci USA 92:7041-7045, 1995.
18. Miller AD, Rosman GJ. Improved retroviral vectors for gene transfer and expression. Biotechniques 7:980-982, 984-986, 989-990, 1989.
19. Markowitz D, Goff S, Bank A. A safe packaging line for gene transfer: Separating viral genes on two different plasmids. J Virol 62:1120-1124, 1988.
20. Hennings H, Shores R, Mitchell P, Spangler EF, Yuspa SH. Induction of papillomas with a high probability of conversion to malignancy. Carcinogenesis 6:1607-1610, 1985.
21. Bauer D, Muller H, Reich J, et al. Identification of differentially expressed mRNA species by an improved display technique (DDRT-PCR). Nucleic Acids Res 21:4272-4280, 1993.
22. Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ. Basic local alignment search tool. J Mol Biol 215:403-410, 1990.
23. Schreiber E, Matthias P, Muller MM, Schaffner W. Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells. Nucleic Acids Res 17:6419, 1989.
24. Rutberg SE, Saez E, Glick A, Dlugosz AA, Spiegelman BM, Yuspa SH. Differentiation of mouse keratinocytes is accompanied by PKC-dependent changes in AP-1 proteins. Oncogene 13:167-176, 1996.
25. Badley JE, Bishop GA, St. John T. Frelinger JA. A simple, rapid method for the purification of poly A+ RNA. Biotechniques 6:114-116, 1988.
26. Meyuhas O, Klein A. The mouse ribosomal protein L7 gene. Its primary structure and functional analysis of the promoter region. J Biol Chem 265:11465-11473, 1990.
27. Hansen LA, Tennant RW. Follicular origin of epidermal papillomas in v-Ha-ras transgenic TG.AC mouse skin. Proc Natl Acad Sci USA 91:7822-7826, 1994.
28. Negrini M, Silini E, Kozak C, Tsujimoto Y, Croce CM. Molecular analysis of mbcl-2: Structure and expression of the murine gene homologous to the human gene involved in follicular lymphoma. Cell 49:455-463, 1987.
29. Bianchi L, Farrace MG, Nini G, Piacentini M. Abnormal Bcl-2 and "tissue" transglutaminase expression in psoriatic skin. J Invest Dermatol 103:829-833, 1994.
30. Stenn KS, Lawrence L, Veis D, Korsmeyer S, Seiberg M. Expression of the bcl-2 protooncogene in the cycling adult mouse hair follicle. J Invest Dermatol 103:107-111, 1994.
31. Cerroni L, Kerl H. Aberrant bcl-2 protein expression provides a possible mechanism of neoplastic cell growth in cutaneous basal-cell carcinoma. J Cutan Pathol 21:398-403, 1994.
32. Smoller BR, Van de Rijn M, Lebrun D, Warnke RA. bcl-2 expression reliably distinguishes trichoepitheliomas from basal cell carcinomas. Br J Dermatol 131:28-31, 1994.
33. Nakagawa K, Yamamura K, Maeda S, Ichihashi M. bcl-2 expression in epidermal keratinocytic diseases. Cancer 74:1720-1724, 1994.
34. Krainer AR, Mayeda A, Kozak D, Binns G. Functional expression of cloned human splicing factor SF2: Homology to RNA-binding proteins, U1 70K, and Drosophila splicing regulators. Cell 66:383-394, 1991.
35. Sun Y, Hegamyer G, Kim H, et al. Molecular cloning of mouse tissue inhibitor of metalloproteinases-3 and its promoter. Specific lack of expression in neoplastic JB6 cells may reflect altered gene methylation. J Biol Chem 270:19312-19319, 1995.
36. Siddiqui J, Haqqi TM, Bicker DR, Mkuhtar H. Identification and partial characterization of novel genes by differential display of mRNAs in squamous papillomas induced in skin of SENCAR mice. Int J Oncol 9:211-216, 1996.
37. Liang P, Pardee AB. Recent advances in differential display. Curr Opin Immunol 7:274-280, 1995.
38. Hadman M, Adam BL, Wright GL, Jr., Bos TJ. Modifications to the differential display technique reduce background and increase sensitivity. Anal Biochem 226:383-386, 1995.
39. Yeatman TJ, Mao W. Identification of a differentially-expressed message associated with colon cancer liver metastatis using an improved method of differential display. Nucleic Acids Res 23:4007-4008, 1995.
40. 33P-labeled primer increases the sensitivity and specificity of mRNA differential display. Biotechniques 18:424-425, 1995.
41. Mou L, Miller H, Li J, Wang E, Chalifour L. Improvements to the differential display method for gene analysis. Biochem Biophys Res Commun 199:564-569, 1994.
42. Callard D, Lescure B, Mazzolini L. A method for the elimination of false positives generated by the mRNA differential display technique. Biotechniques 16:1096-1097, 1100-1103, 1994.
43. Tsujimoto Y, Finger LR, Yunis J, Nowell PC, Croce CM. Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation. Science 226:1097-1099, 1984.
44. Vaux DL, Cory S, Adams JM. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 335:440-442, 1988.
45. Hockenbery D, Nunez G, Milliman C, Schreiber RD, Korsmeyer SJ. Bcl-2 is an inner mitochrondrial membrane protein that blocks programmed cell death. Nature 348:334-336, 1990.
46. Chen-Levy Z, Nourse J, Cleary ML. The bcl-2 candidate protooncogene product is a 24-kilodalton integral-membrane protein highly expressed in lymphoid cell lines and lymphomas carrying the t(14;18) translocation. Mol Cell Biol 9:701-710, 1989.
47. Graninger WB, Seto M, Boutain B, Goldman P, Korsmeyer SJ. Expression of Bcl-2 and Bcl-2-lg fusion transcripts in normal and neoplastic cells. J Clin Invest 80:1512-1515, 1987.
48. Seto M, Jaeger U, Hockett RD, et al. Alternative promoters and exons, somatic mutation and deregulation of the Bcl-2-lg fusion gene in lymphoma. EMBO J 7:123-131, 1988.
49. Cleary ML, Smith SD, Sklar J. Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bd-2/immunoglobulin transcript resulting from the t(14;18) translocation. Cell 47:19-28, 1986.
50. Ayhan A, Yasui W, Yokozaki H, Seto M, Ueda R, Tahara E. Loss of heterozygosity at the bcl-2 gene locus and expression of bcl-2 in human gastric and colorectal carcinomas. Jpn J Cancer Res 85:584-591, 1994.
51. Sinicrope FA, Ruan SB, Cleary KR, Stephens LC, Lee JJ, Levin B, bcl-2 and p53 oncoprotein expression during colorectal tumorigenesis. Cancer Res 55:237-241, 1995.
52. McDonnell TJ, Troncoso P, Brisbay SM, et al. Expression of the protooncogene bcl-2 in the prostate and its association with emergence of androgen-independent prostate cancer. Cancer Res 52:6940-6944, 1992
53. Polakowska RR, Piacentini M, Bartlett R, Goldsmith LA, Haake AR. Apoptosis in human skin development: Morphogenesis, penderm, and stem cells. Dev Dyn 199:176-188, 1994.
54. Marthinuss J, Lawrence L, Seiberg M. Apoptosis in Pam212, an epidermal keratinocyte cell line: A possible role for bcl-2 in epidermal differentiation. Cell Growth Differ 6:239-250, 1995.
55. Zuo P, Manley JL. The human splicing factor ASF/SF2 can specifically recognize pre-mRNA 5′ splice sites. Proc Natl Acad Sci USA 19:3363-3367, 1994.
56. Krainer AR, Conway GC, Kozak D. The essential pre-mRNA splicing factor SF2 influences 5′ splice site selection by activating proximal sites. Cell 62:35-42, 1990.
57. Mayeda A, Krainer AR. Regulation of alternative pre-mRNA splicing by hnRNP A1 and splicing factor SF2. Cell 68:365-375, 1992.
58. Mayeda A, Helfman DM, Krainer AR. Modulation of exon skipping and inclusion by heterogeneous nuclear ribonucleoprotem A1 and pre-mRNA splicing factor SF2/ASF [published erratum appears in Mol Cell Biol 1993 Jul;13(7):4458]. Mol Cell Biol 13:2993-3001, 1993.
59. Ambartsumian N, Tarabykina S, Grigorian M, et al. Characterization of two splice variants of metastasis-associated human mts 1 gene. Gene 159:125-130, 1995.
60. Kaaijk P, Troost D, Morsink F, et al. Expression of CD44 splice variants in human primary brain tumors. J Neurooncol 26:185-190, 1995.
61. Hewitt SM, Saunders GF. Differentially spliced exon 5 of the Wilms' tumor gene WT1 modifies gene function. Anticancer Res 16:621-626, 1996.