Determination of hemoglobin adducts following oral administration of 1- nitropyrene to rats using gas chromatography-tandem mass spectrometry

Journal of Chromatography B: Biomedical Applications

Volumn 701, Issue 1, 1997, Pages 19-28

  Van Bekkum, Y M ^a   Scheepers, P T J ^a   Van den Broek, P H H ^a   Velders, D D ^a   Noordhoek, J ^a   Bos, R P ^a  

^a RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

Author keywords

1 Nitropyrene; Hemoglobin adducts

Indexed keywords

1 NITROPYRENE; AMMONIUM CHLORIDE; BUTYRIC ACID DERIVATIVE; DIMETHYL SULFOXIDE; DODECYL SULFATE SODIUM; HEMOGLOBIN; HEXANE; HYDROCHLORIC ACID; POTASSIUM DIHYDROGEN PHOSPHATE; PYRENE DERIVATIVE; SODIUM HYDROXIDE; TRIOCTANOIN; TROMETAMOL;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DNA ADDUCT; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL MONITORING; GAS CHROMATOGRAPHY; HEMOGLOBIN DETERMINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; INTRAGASTRIC DRUG ADMINISTRATION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; TANDEM MASS SPECTROMETRY;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL MARKERS; CARCINOGENS, ENVIRONMENTAL; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HEMOGLOBINS; HYDROLYSIS; MALE; PYRENES; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TIME FACTORS;

EID: 0030783612     PISSN: 15726495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4347(97)00356-3     Document Type: Article

References (23)

1. IARC, Diesel and Gasoline Engine Exhaust and Some Nitroarenes, Monographs, Vol. 46, IARC, Lyon, France, 1989.
2. P.T.J. Scheepers, M.H.J. Martens, D.D. Velders, P. Fijneman, M. Van Kerkhoven, J. Noordhoek, R.P. Bos, Environ. Mol. Mutagen. 25 (1995) 134.
3. Health Effects Institute, Diesel Exhaust: A Critical Analysis of Emissions, Exposure and Health Effects, Health Effects Institute, Cambridge, MA. 1995.
4. P.B. Farmer, E. Bailey, S.M. Gorf, M. Tornqvist, S. Osterman-Golkar, A. Kautiainen, D.P. Lewis-Enright, Carcino-genesis 7 (1986) 637.
5. S. Osterman-Golkar. K. Peltonen, T. Anttinen-Klemetti, H.H. Landin, V. Zorzec, M. Sorsa, Mutagenesis 11 (1996) 145.
6. G. Sabbioni, J. Wei, Y.-Y. Liu, J. Chromatogr. B 682 (1996) 243.
7. H.-G. Neumann, O. Albrecht, C.Van Dorp, I. Zwirner-Baier, Clin. Chem. 41 (1995) 771.
8. G. Sabbioni, A. Beyerbach, J. Chromatogr. B 667 (1995) 75.
9. P.T.J. Scheepers, D.D. Velders, M.M.E. Straetemans, J.C. Ouwerkerk, L.A. van Vliet, R.P. Bos, J. Chromatogr. 619 (1993) 215.
10. L.M. Bail, M.J. Kohan, J. Inmon, L.D. Claxton, J. Lewtas, Carcinogenesis 5 (1984) 1557.
11. P.C. Howard, T.J. Flammang, F.A. Beland, Carcinogenesis 6 (1985) 243.
12. K. El-Bayoumy, B. Johnson, A.K. Roy, P. Upadhyaya, S. Partian, S.S. Hecht, Environ. Health Perspect. 102 (1994) 31.
13. T. Kinouchi, K. Kataoka, K. Miyanishi, S. Akimotot, Y. Ohnishi, Tohoku J. Exp. Med. 168 (1992) 119.
14. L.C. Green, P.L. Skipper, R.J. Turesky, M.S. Bryant, S.R. Tannenbaum, Cancer Res. 44 (1984) 4254.
15. B.W. Day, S. Naylor, L.-S. Gan, Y. Sahali, T.T. Nguyen, P.L. Skipper, J.S. Wishnok, S.R. Tannenbaum, Cancer Res. 50 (1990) 4611.
16. D.A. Hutchins, P.L. Skipper, S. Naylor, S.R. Tannenbaum, Cancer Res. 48 (1988) 4756.
17. K. El-Bayoumy, B. Johnson. S. Partian, P. Upadhyaya, S.S. Hecht, Carcinogenesis 15 (1994) 119.
18. Health Effects Institute, in K. El-Bayoumy, B.E. Johnson, A.K. Roy, P. Upadhyaya and S.J. Partian, Research Report No. 64, Health Effects Institute. Cambridge, MA, 1994.
19. H.-G. Neumann, Arch. Toxicol. 56 (1984) 1.
20. H.-G. Neumann, in H. Bartsch, K. Hemminki and K. O'Neill (Editors), Methods for Detecting DNA Damaging Agents in Humans. Application in Cancer Epidemiology and Prevention, IARC Scientific Publications No. 89. [ARC, Lyon, France, 1988, p. 157.
21. J. Suzuki, S.-I. Meguro, O. Morita, S. Hirayama, S. Suzuki, Biochem. Pharmacol. 38 (1989) 3511.
22. MM. Bradford, Anal. Biochem. 72 (1976) 248.
23. T. Kinouchi, K. Nishifuji, Y. Ohnishi, Carcinogenesis 11 (1990) 1381.