Phasing methods for protein crystallography

Current Opinion in Structural Biology

Volumn 7, Issue 5, 1997, Pages 672-680

  Hauptman, Herbert ^a  

^a HAUPTMAN WOODWARD MEDICAL RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN;

ACCURACY; ALGORITHM; CRYSTALLOGRAPHY; FEASIBILITY STUDY; PRIORITY JOURNAL; PROTEIN STRUCTURE; REVIEW; TECHNIQUE; X RAY DIFFRACTION;

EID: 0030783379     PISSN: 0959440X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-440X(97)80077-2     Document Type: Article

References (52)

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45. Hauptman H. Looking ahead. Acta Crystallogr B. 51:1995;416-422.
46. Anderson DH, Weiss MS, Eisenberg D. A challenging case for protein crystal structure determination: the mating pheromone Er-1 from Euplotes raikovi. Acta Crystallogr D. 52:1996;469-480 This structure, impossible to solve using conventional direct methods techniques, was finally solved by the authors using molecular replacement (which required the previously acquired structure using NMR) and, simultaneously, by a routine application of Shake-and-Bake. of outstanding interest.
47. Prive G, Ogihara N, Wesson L, Cascio D, Eisenberg D. A designer peptide at high resolution: Shake-and-Bake solution of a 400 atom structure. Abstract W008 of American Crystallography Association Meeting. 23-28 July 1995;. Montreal, Canada.
48. Hu S-H, Gehrmann J, Guddat LW, Alewood PF, Craik DJ, Martin JL. The 1.1 crystal structure of the neuronal acetylcholine receptor antagonist, α-conotoxin PnlA from Conus pennacens. Structure. 4:1996;417-423 Another structure, impossible to solve using any other method, was routinely solved using Shake-and-Bake. of special interest.
49. Guddat LW, Martin JL, Shan L, Edmundson AB, Gray WR. Three-dimensional structure of the α-conotoxin GI at 1.2 Å resolution. Biochemistry. 35:1996;11329-11335 Yet another structure solvable only by Shake-and-Bake. of special interest.
50. Smith GD, Blessing RH, Ealick SE, Fontecilla-Camps JC, Hauptman HA, Housset D, Langs DA, Miller R. The ab initio structure and refinement of a scorpion protein toxin. Abstract E1446 of the IUCr Meeting. 8-13 August 1996; This structure had defeated all attempts at solution using traditional direct methods. It was solved using Shake-and-Bake. With 624 non-H atoms, it was, at the time solution, the largest structure solved using direct methods. of outstanding interest.
51. Loll PJ, Revivino AE, Korty BD, Axelsen PH. Simultaneous recognition of a carboxylate-containing ligand and an intramolecular surrogate ligand in the crystal structure of an asymmetric vancomycin dimer. J Am Chem Soc. 119:1997;1516-1522 Another Shake-and-Bake solution. Also solved by SHELX-D. (See [11].) of outstanding interest of special interest.
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