Chronic portal hypotensive effects of tetrandrine and verapamil on portal hypertensive rats

Asia Pacific Journal of Pharmacology

Volumn 12, Issue 1-2, 1997, Pages 31-35

  Huang, Y T ^a   Liu, T B ^a   Cheng, Y R ^a   Lin, H C ^a   Chen, C F ^b   Chen, S M ^c  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE   (Taiwan)

^c JEN AI HOSPITAL   (Taiwan)

Author keywords

Calcium channel antagonist; Portal hypertension; Tetrandrine; Verapamil

Indexed keywords

CALCIUM ANTAGONIST; TETRANDRINE; VERAPAMIL;

ANIMAL MODEL; BODY WEIGHT; CONFERENCE PAPER; CONTROLLED STUDY; DOSE RESPONSE; HEART RATE; LONG TERM CARE; MEAN ARTERIAL PRESSURE; NONHUMAN; ORAL DRUG ADMINISTRATION; PORTAL HYPERTENSION; PORTAL VEIN BLOOD PRESSURE; RAT;

EID: 0030783028     PISSN: 02179687     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (22)

1. + channels. Life Sciences 1995; 56: 295-306.
2. ++ antagonist: effects and mechanisms of action in vascular smooth muscle cells. Journal of Pharmacology and Experimental Therapeutics 1995; 273: 32-9.
3. Qian JQ, Thoolen MJMC, van Meel JCA, Timmermans PBMWM, van Zwieten PA. Hypotensive activity of tetrandrine in rats: investigation into its mode of action. Pharmacology 1983, 26: 187-97.
4. Xu Y, Rao M-R. Effects of tetrandrine on left ventricle hypertrophy in deoxycorticosterone acetate-salt hypertensive rats. European Journal of Pharmacology 1995; 278: 1-7.
5. D'Amico G, Pagliaro L, Bosch J. The treatment of portal hypertension: a meta-analytic review. Hepatology 1995; 22: 332-54.
6. Lebrec D. Pharmacological treatment of portal hypertension: hemodynamic effects and prevention of bleeding. Pharmacology and Therapeutics 1994; 61: 65-107.
7. Imperiale TF, Teran JC, McCullouch AJ. A metaanalysis of somatostatin versus vasopressin in the management of acute esophageal variceal hemorrhage. Gastroenterology 1995; 109: 1289-94.
8. Reichen J, Le M. Verapamil favorably influences hepatic microvascular exchange and function in rats with cirrhosis of liver. Journal of Clinical Investigation 1986; 78: 448-55.
9. Reichen J, Hirlinger A, Ha HR, Sagesser S. Chronic verapamil administration lowers portal pressure and improves hepatic function in rats with liver cirrhosis. Journal of Hepatology 1986; 3: 49-58.
10. Liu T-B, Lin H-C, Huang Y-T, Sun C-M, Hong C-Y. Portal hypotensive effects of tetrandrine and verapmil on portal hypertensive rats. Journal of Pharmacy and Pharmacology 1997; 49: 85-88.
11. Chojkier M, Groszmann RJ. Measurement of portal systemic shunting in the rat by using γ-labeled microspheres. American Journal of Physiology 1981; 240: G371-5.
12. Huang Y-T, Wang G-F, Yang MCM, Chang S-P, Lin H-C, Hong C-Y. Vascular hyporesponsiveness in aorta from portal hypertensive rats: possible sites of involvement. Journal of Pharmacology and Experimental Therapeutics 1996; 278: 535-41.
13. Lin H-C, Soubrane O, Cailmail S, Lebrec D. Early chronic administration of propranolol reduces the severity of portal hypertension and portal-systemic shunts in conscious portal vein stenosed rats. Journal of Hepatology 1991; 13 213-9.
14. Lin H-C, Soubrane O, Lebrec D. Prevention of portal hypertension and portosystemic shunts by early chronic administration of clonidine in conscious portal vein-stenosed rats. Hepatology 1991; 14: 325-30
15. ω-Nitro-L-arginine ameliorates portal-systemic shunting in portal-hypertensive rats. Gastroenterology 1993; 105: 1464-70.
16. Zeng F-D, Shaw DH Jr, Ogilvie RI. Kinetic disposition and hemodynamic effects of tetrandrine in anesthetized dogs. Journal of Cardiovascular Pharmacology 1985; 7: 1034-9.
17. Kazda S, Knorr A. Calcium antagonists. In: Ganten D, Mulrow PJ, eds. Pharmacology of Anti-hypertensive Therapeutics. Berlin: Springer-Verlag, 1990: 301-75.
18. Reichen J. Liver function and pharmacological considerations in pathogenesis and treatment of portal hypertension. Hepatology 1990; 11: 1066-78.
19. Lay C-S, Tsai Y-T, Yang C-M, Chen H-I, Simchon S, Chien S, Lo K-J. Effect of verapamil on splanchnic haemodynamics in a portal hypertensive rat model. Journal of Gastroenterology and Hepatology 1990; 5: 141-8.
20. Kong C-W, Lay C-S, Tsai Y-T, Yeh C-L, Lai K-H, Lee S-D, Lo K-J, Chiang BN. The hemodynamic effect of verapamil on portal hypertension in patients with postnecrotic cirrhosis. Hepatology 1986; 6: 423-6
21. Lay C-S, Tsai Y-T, Kong C-W, Lee F-Y, Lee S-D, Chen K-Y, Chiang BN, Lo K-J. Effects of verapamil on estimated hepatic blood flow in patients with HBsAg-positive cirrhosis Hepato-gastroenterology 1988; 35: 121-4.
22. Opie LH. Calcium channel antagonists in the treatment of coronary artery disease: fundamental pharmacological properties relevant to clinical use. Progress in Cardiovascular Diseases 1996; 38: 273-90.