Analysis of biofluids and chemical mixtures in non-deuterated solvents with 1H diffusion-weighted PFG phase-sensitive double-quantum NMR spectroscopy

NMR in Biomedicine

Volumn 10, Issue 6, 1997, Pages 285-291

  Dalvit, Claudio ^a   Böhlen, Jean Marc ^b  

^a NOVARTIS PHARMA AG   (Switzerland)

^b BRUKER BIOSPIN AG   (Switzerland)

Author keywords

Biofluids; Diffusion; Double quantum NMR experiments; Magic angle pulsed field gradients

Indexed keywords

ALANINE; CHEMICAL COMPOUND; CITRIC ACID; DEUTERIUM OXIDE; GLUCOSE; LACTIC ACID; LOW DENSITY LIPOPROTEIN; RAUWOLSCINE; SOLVENT; TYROSINE; VALINE; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL TISSUE; ARTICLE; BODY FLUID; CHEMICAL COMPOSITION; DIFFUSION COEFFICIENT; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PLASMA; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT;

AMINO ACIDS; ANIMALS; BLOOD CHEMICAL ANALYSIS; BLOOD GLUCOSE; CITRIC ACID; DEUTERIUM; DIFFUSION; LACTIC ACID; LIPOPROTEINS, LDL; LIPOPROTEINS, VLDL; MALE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTONS; QUANTUM THEORY; RATS; RATS, SPRAGUE-DAWLEY; SENSITIVITY AND SPECIFICITY; SOLVENTS;

ANIMALIA;

EID: 0030782658     PISSN: 09523480     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1492(199709)10:6<285::AID-NBM485>3.0.CO;2-1     Document Type: Article

References (42)

1. Stejskal, E. O. and Tanner, J. E. Spin diffusion measurements: spin echoes in the presence of a time-dependent field gradient. J. Chem. Phys. 42, 288-292 (1965).
2. Tanner, J. E. Use of the stimulated echo in NMR diffusion studies. J. Chem. Phys. 52, 2523-2526 (1970).
3. Stilbs, P. Fourier transform pulsed-gradient spin-echo studies of molecular diffusion. Prog. NMR Spectrosc. 19, 1-45 (1987).
4. Morris, K. F. and Johnson, C. S. Jr. Diffusion-ordered two-dimensional nuclear magnetic resonance spectroscopy. J. Am. Chem. Soc. 114, 3139-3141 (1992).
5. Morris, K. F. and Johnson, C. S. Jr. Resolution of discrete and continuous molecular size distribution by means of diffusion-ordered 2D NMR spectroscopy. J. Am. Chem. Soc. 115, 4291-4299 (1993).
6. Morris, K. F., Stilbs, P. and Johnson, C. S. Jr. Analysis of mixtures based on molecular size and hydrophobicity by means of diffusion-ordered 2D NMR. Anal. Chem. 66, 211-215 (1994).
7. Barjat, H., Morris, G. A., Smart, S., Swanson, A. G. and Williams, S. C. R. High-resolution diffusion-ordered 2D spectroscopy (HR-DOSY) - a new tool for the analysis of complex mixtures. J. Magn. Reson. B 108, 170-172 (1995).
8. Altieri, A. S., Hinton, D. P. and Byrd, R. A. Association of biomolecular systems via pulsed field gradient NMR diffusion measurements. J. Am. Chem. Soc. 117, 7566-7567 (1995).
9. Dingley, A. J., Mackay, J. P., Chapman, B. E., Morris, M. B., Kuchel, P. W., Hambly, B. D. and King, G. F. Measuring protein self-association using pulsed-field-gradient NMR spectroscopy: application to myosin light chain 2. J. Biomol. NMR 6, 321-328 (1995).
10. Wu, D., Chen, A. and Johnson, C. S. Jr. Three-dimensional diffusion-ordered NMR spectroscopy: the homonuclear COSY-DOSY experiment. J. Magn. Reson. A. 121, 88-91 (1996).
11. Mutzenhardt, P. and Canet, D. Behavior of longitudinal spin orders in NMR measurements of diffusion coefficients using radiofrequency field gradients. J. Chem. Phys. 105, 4405-4411 (1996).
12. Gozansky, E. K. and Gorenstein, D. G. DOSY-NOESY: diffusion-ordered NOESY. J. Magn. Reson. B 111, 94-96 (1996).
13. Lin, M. and Shapiro, M. J. Mixture analysis in combinatorial chemistry. Application of diffusion-resolved NMR spectroscopy. J. Org. Chem. 61, 7617-7619 (1996).
14. Wu, D., Chen, A. and Johnson, C. S. Jr. Heteronuclear-detected diffusion-ordered NMR spectroscopy through coherence transfer. J. Magn. Reson. A 123, 215-218 (1996).
15. Jerschow, A. and Müller, N. 3D diffusion-ordered TOCSY for slowly diffusing molecules. J. Magn. Reson. A 123, 222-225 (1996).
16. Stilbs, P., Paulsen, K. and Griffiths, P. C. Global least-squares analysis of large, correlated spectral data sets: Application to component-resolved FT-PGSE NMR spectroscopy. J. Phys. Chem. 100, 8180-8189 (1996).
17. 1H NMR spectroscopy of biological fluids. Anal. Chem. 68, 3370-3376 (1996).
18. Dalvit, C. and Böhlen, J. M. Spectral editing and water suppression in double-quantum experiments. J. Magn. Reson. B 111, 76-80 (1996).
19. 2O signal in the PFG DQ experiments recorded with only z Gradients. J. Magn. Reson. 126, 149-153 (1997).
20. Keeler, J., Clowes, R. T., Davis, A. L. and Laue, E. D. In Methods in Enzymology, N. J. Oppenheimer, T. L. James (Eds), Vol. 239, p. 145. Academic Press, San Diego, 1994.
21. Canet, D. and Decorps, M. In Dynamics of Solutions Fluid Mixture by NMR, J. J. Delpuech (Ed.), p. 309. Wiley, New York (1995).
22. Parella, T. High-quality 1D spectra by implementing pulsed-field gradients as the coherence pathway selection procedure. Magn. Reson. Chem. 34, 329-347 (1996).
23. 2O double-quantum signal and of the radiation-damping effect in double-quantum experiments. J. Magn. Reson. B 113, 195-200 (1996).
24. Ruiz-Cabello, J., Vuister, G. W., Moonen, C. T. W., Van Gelderen, P., Cohen, J. S. and Van Zijl, P. C. M. Gradient-enhanced heteronuclear correlation Spectroscopy. Theory and experimental aspects. J. Magn. Reson. 100, 282-302 (1992).
25. States, D. J., Haberkorn, R. A. and Ruben, D. J. A two dimensional nuclear Overhauser experiment with pure absorption phase in four quadrants. J. Magn. Reson. 48, 286-292 (1982).
26. Warren, W. S., Richter, W., Andreotti, A. H. and Farmer II, B. T. Generation of impossible cross-peaks between bulk water and biomolecules in solution NMR. Science 262, 2005-2009 (1993).
27. Van Zijl, P. C. M., Johnson, M. O., Mori, S. and Hurd, R. E. Magic-angle-gradient doube-quantum-filtered COSY. J. Magn. Reson. A 113, 265-270 (1995).
28. Dalvit, C. and Böhlen J. M. Multiple-solvent suppression in double-quantum NMR experiments with magic angle pulsed field gradients. Magn. Reson. Chem. 34, 829-833 (1996).
29. Mattiello, D. L., Warren, W. S., Müller, L. and Farmer II, B. T. Minimizing the water resonance in biological NMR: characterization and suppression of intermolecular dipolar interaction by multiple-axis gradients. J. Am. Chem. Soc. 118, 3253-3261 (1996).
30. McCoy, M. and Warren, W. S. Three-quantum nuclear magnetic resonance spectroscopy of liquid water: intermolecular multiple-quantum coherence generated by spin-cavity coupling. J. Chem. Phys. 93, 858-860 (1990).
31. Price, W. S. and Kuchel, P. W. Effect of nonrectangular field gradient pulses in the Stejskal and Tanner (diffusion) pulse sequence. J. Magn. Reson. 94, 133-139 (1991).
32. Birlirakis, N. and Guittet, E. A. A new approach in the use of gradients for size-resolved 2D-NMR experiments. J. Am. Chem. Soc. 118, 13083-13084 (1996).
33. 13C NMR spectroscopy of human blood plasma. Anal. Chem. 67, 793-811 (1995).
34. Martin, J. F., Selwyn, L. S., Vold, R. R. and Vold, R. L. The determination of translational diffusion constants in liquid crystals from pulsed field gradient double quantum spin echo decays. J. Chem. Phys. 76, 2632-2634 (1982).
35. Zax, D. and Pines, A. Study of anisotropic diffusion of oriented molecules by multiple quantum spin echoes. J. Chem. Phys. 78, 6333-6334 (1983).
36. Sotak, C. H. A method for measuring the apparent diffusion coefficient of in vivo lactic acid using double-quantum coherence-transfer spectroscopy. J. Magn. Reson. 90, 198-204 (1990).
37. Wu, D., Chen, A. and Johnson, C. S. Jr. An improved diffusion-ordered spectroscopy experiment incorporating bipolar-gradient pulses. J. Magn. Reson. A 115, 260-264 (1995).
38. Wider, G., Dötsch, V. and Wüthrich, K. Self-compensating pulsed magnetic-field gradients for short recovery times. J. Magn. Reson. A 108, 255-258 (1994).
39. Gibbs, S. J. and Johnson, C. S. Jr. A PFG NMR experiment for accurate diffusion and flow studies in the presence of eddy currents. J. Magn. Reson. 93, 395-402 (1991).
40. Dalvit, C. Design of 2D and 3D homonuclear PFG 2Q-NOESY and 2Q-TOCSY experiments for the assignment of proton spectra of unlabeled proteins. J. Magn. Reson. B 110, 225-230 (1996).
41. 13C-Edited double-quantum spectroscopy of peptides and proteins. J. Magn. Reson. B 105, 83-87 (1994).
42. Sørensen, O. W., Rance, M. and Ernst, R. R. z Filters for purging phase- or muitiplet-distorted spectra. J. Magn. Reson. 56, 527-534 (1984).