-
1
-
-
0023225120
-
Resolution of racemic carboxylic analogues of purine nucleosides through the action of adenosine deaminase, antiviral activity of the carbocylic 2′-deoxyguanosine enantiomers
-
Secrist, J. A., III; Montgomery, J. A.; Shealy, Y. F.; O. Dell, C. A.; Clayton, S. J. Resolution of racemic carboxylic analogues of purine nucleosides through the action of adenosine deaminase, antiviral activity of the carbocylic 2′-deoxyguanosine enantiomers. J. Med. Chem. 1987, 30, 746-749.
-
(1987)
J. Med. Chem.
, vol.30
, pp. 746-749
-
-
Secrist III, J.A.1
Montgomery, J.A.2
Shealy, Y.F.3
Dell C A, O.4
Clayton, S.J.5
-
2
-
-
0027656782
-
Enzymatic production of optically pure (2′R-cis)-2′-deoxy-3′-thiacytidine (3TC, Lamivudine): A potent anti HIV agent
-
Mahmoudian, M.; Baines, B. S.; Drake, C. S.; Hale, R. S.; Jones, P.; Piercey, J. E.; Montgomery, D. S.; Purvis, I. J.; Storer, R.; Dawson, M. J.; Lawrence, G. C. Enzymatic production of optically pure (2′R-cis)-2′-deoxy-3′-thiacytidine (3TC, Lamivudine): A potent anti HIV agent. Enzyme Microb. Technol. 1993, 15, 749-755.
-
(1993)
Enzyme Microb. Technol.
, vol.15
, pp. 749-755
-
-
Mahmoudian, M.1
Baines, B.S.2
Drake, C.S.3
Hale, R.S.4
Jones, P.5
Piercey, J.E.6
Montgomery, D.S.7
Purvis, I.J.8
Storer, R.9
Dawson, M.J.10
Lawrence, G.C.11
-
3
-
-
0025570249
-
New approaches to the synthesis of antiviral nucleosides
-
Hutchinson, D. W. New approaches to the synthesis of antiviral nucleosides. TIBTECH 1990, 8, 348-353.
-
(1990)
TIBTECH
, vol.8
, pp. 348-353
-
-
Hutchinson, D.W.1
-
4
-
-
0028877076
-
The effect of absolute configuration on the anti-HIV and anti-HBV activity of nucleoside analogues
-
Furman, P. A.; Wilson, J. E.; Reardon, J. E.; Painter, G. R. The effect of absolute configuration on the anti-HIV and anti-HBV activity of nucleoside analogues. Antiviral Chem. Chemother. 1995, 6, 345-355.
-
(1995)
Antiviral Chem. Chemother.
, vol.6
, pp. 345-355
-
-
Furman, P.A.1
Wilson, J.E.2
Reardon, J.E.3
Painter, G.R.4
-
5
-
-
0028230923
-
Antihuman immunodeficiency virus activities of the β-L enantiomers of 2′,3′-dideoxycytidine and its 5-fluoro derivative in vitro
-
Gosselin, G.; Schinazi, R. F.; Sommadossi, J.-P.; Mathe, C.; Bergogne, M.-C.; Aubertin, A.-M.; Kirn, A.; Imbach, J.-L. Antihuman immunodeficiency virus activities of the β-L enantiomers of 2′,3′-dideoxycytidine and its 5-fluoro derivative in vitro. Antimicrob. Agents Chemother. 1994, 38, 1292-1297.
-
(1994)
Antimicrob. Agents Chemother.
, vol.38
, pp. 1292-1297
-
-
Gosselin, G.1
Schinazi, R.F.2
Sommadossi, J.-P.3
Mathe, C.4
Bergogne, M.-C.5
Aubertin, A.-M.6
Kirn, A.7
Imbach, J.-L.8
-
6
-
-
0028296866
-
Influence of stereochemistry on antiviral activities and resistance profiles of dideoxycytidine nucleosides
-
Van Draanen, N. A.; Tisdale, M.; Parry, N. R.; Jansen, R.; Dorsife, R. E.; Tuttle, J. V.; Averett, D. R.; Koszalka, G. W. Influence of stereochemistry on antiviral activities and resistance profiles of dideoxycytidine nucleosides. Antimicrob. Agents Chemother. 1994, 38, 868-871.
-
(1994)
Antimicrob. Agents Chemother.
, vol.38
, pp. 868-871
-
-
Van Draanen, N.A.1
Tisdale, M.2
Parry, N.R.3
Jansen, R.4
Dorsife, R.E.5
Tuttle, J.V.6
Averett, D.R.7
Koszalka, G.W.8
-
7
-
-
0027981440
-
Pure nucleoside enantiomers of β-2′,3′-dideoxycytidine analogues are selective inhibitors of hepatitis B virus in vitro
-
Schinazi, R. F.; Gosselin, G.; Faraj, A.; Korba, B. E.; Liotta, D. C.; Chu, C. K.; Mathé, C.; Imbach, J.-L.; Sommadossi, J.-P. Pure nucleoside enantiomers of β-2′,3′-dideoxycytidine analogues are selective inhibitors of hepatitis B virus in vitro. Antimicrob. Agents Chemother. 1994, 38, 2172-2174.
-
(1994)
Antimicrob. Agents Chemother.
, vol.38
, pp. 2172-2174
-
-
Schinazi, R.F.1
Gosselin, G.2
Faraj, A.3
Korba, B.E.4
Liotta, D.C.5
Chu, C.K.6
Mathé, C.7
Imbach, J.-L.8
Sommadossi, J.-P.9
-
8
-
-
0029618709
-
Lack of stereospecificity of some cellular and viral enzymes involved in the synthesis of deoxyribonucleotides and DNA: Molecular basis for the antiviral activity of unnatural L-β-nucleosides
-
Spadari, S.; Maga, G.; Verri, A.; Bendiscioli, A.; Tondelli, L.; Capobianco, M.; Colonna, F.; Garbesi, A.; Focher, F. Lack of stereospecificity of some cellular and viral enzymes involved in the synthesis of deoxyribonucleotides and DNA: Molecular basis for the antiviral activity of unnatural L-β-nucleosides. Biochimie 1995, 77, 861-867.
-
(1995)
Biochimie
, vol.77
, pp. 861-867
-
-
Spadari, S.1
Maga, G.2
Verri, A.3
Bendiscioli, A.4
Tondelli, L.5
Capobianco, M.6
Colonna, F.7
Garbesi, A.8
Focher, F.9
-
9
-
-
0026491206
-
β-L-Thymidine 5′-triphosphate analogues as DNA polymerase substrates
-
Van Draanen, N. A.; Tucker, S. C.; Boyd, F. L.; Trotter, B. W.; Reardon, J. E. β-L-Thymidine 5′-triphosphate analogues as DNA polymerase substrates. J. Biol. Chem. 1992, 267, 25019-25024.
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 25019-25024
-
-
Van Draanen, N.A.1
Tucker, S.C.2
Boyd, F.L.3
Trotter, B.W.4
Reardon, J.E.5
-
10
-
-
0028021844
-
Inhibition of human immunodeficiency virus type 1 reverse transcriptase by the 5′-triphosphate β-enantiomers of cytidine analogues
-
Faraj, A.; Agrofoglio, L. A.; Wakefield, J. K.; McPherson, S.; Morrow, C. D.; Gosselin, G.; Mathe, C.; Imbach, J.-L.; Schinazi, R. F.; Sommadossi, J.-P. Inhibition of human immunodeficiency virus type 1 reverse transcriptase by the 5′-triphosphate β-enantiomers of cytidine analogues. Antimicrob. Agents Chemother. 1994, 38, 2300-2305.
-
(1994)
Antimicrob. Agents Chemother.
, vol.38
, pp. 2300-2305
-
-
Faraj, A.1
Agrofoglio, L.A.2
Wakefield, J.K.3
McPherson, S.4
Morrow, C.D.5
Gosselin, G.6
Mathe, C.7
Imbach, J.-L.8
Schinazi, R.F.9
Sommadossi, J.-P.10
-
11
-
-
0029094279
-
Stereospecificity of human DNA polymerases α,β,γ, δ and ε, HIV-reverse transcriptase, HSV-1 DNA polymerase, calf thymus terminal transferase and E. coli DNA polymerase I in recognizing D- And L-thymidine 5′-triphosphate as substrate
-
Focher, F.; Maga, G.; Bendiscioli, A.; Capobianco, M.; Colonna, F.; Garbesi, A.; Spadari, S. Stereospecificity of human DNA polymerases α,β,γ, δ and ε, HIV-reverse transcriptase, HSV-1 DNA polymerase, calf thymus terminal transferase and E. coli DNA polymerase I in recognizing D- and L-thymidine 5′-triphosphate as substrate. Nucleic Acids Res. 1995, 23, 2840-2847.
-
(1995)
Nucleic Acids Res.
, vol.23
, pp. 2840-2847
-
-
Focher, F.1
Maga, G.2
Bendiscioli, A.3
Capobianco, M.4
Colonna, F.5
Garbesi, A.6
Spadari, S.7
-
12
-
-
0026701851
-
Phosphorylation of carbovir enantiomers by cellular enzymes determines the stereoselectivity of antiviral activity
-
Miller, W. H.; Daluge, S. M.; Garvey, E. P.; Hopkins, S.; Reardon, J. E.; Boyd, F. L.; Miller, R. L. Phosphorylation of carbovir enantiomers by cellular enzymes determines the stereoselectivity of antiviral activity. J. Biol. Chem. 1992, 267, 21220-21224.
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 21220-21224
-
-
Miller, W.H.1
Daluge, S.M.2
Garvey, E.P.3
Hopkins, S.4
Reardon, J.E.5
Boyd, F.L.6
Miller, R.L.7
-
13
-
-
0026697262
-
Deoxycytidine deaminase-resistant stereoisomer is the active form of (±)-dideoxy-3′thiacytidine in the inhibition of hepatitis B virus replication
-
Chang, C.; Doong, S.; Zhou, J. H.; Beach, J. W.; Jeong, L. S.; Chu, C. K.; Tsai, C.; Cheng, Y. Deoxycytidine deaminase-resistant stereoisomer is the active form of (±)-dideoxy-3′thiacytidine in the inhibition of hepatitis B virus replication. J. Biol. Chem. 1992, 267, 13938-13942.
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 13938-13942
-
-
Chang, C.1
Doong, S.2
Zhou, J.H.3
Beach, J.W.4
Jeong, L.S.5
Chu, C.K.6
Tsai, C.7
Cheng, Y.8
-
14
-
-
0026469165
-
The anti-hepatitis B virus activities, cytotoxicities, and anabolic profiles of the (-) and (+) enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine
-
Furman, P. A.; Davis, M.; Liotta, D. C.; Paff, M.; Frick, L. W.; Nelson, D. J.; Dornsife, R. E.; Wurster, J. A.; Wilson, L. J.; Fyfe, J. A.; Tuttle, J. V.; Miller, W. H.; Condreay, L.; Averett, D. R.; Schinazi, R. F.; Painter, G. R. The anti-hepatitis B virus activities, cytotoxicities, and anabolic profiles of the (-) and (+) enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine. Antimicrob. Agents Chemother. 1992, 36, 2686-2692.
-
(1992)
Antimicrob. Agents Chemother.
, vol.36
, pp. 2686-2692
-
-
Furman, P.A.1
Davis, M.2
Liotta, D.C.3
Paff, M.4
Frick, L.W.5
Nelson, D.J.6
Dornsife, R.E.7
Wurster, J.A.8
Wilson, L.J.9
Fyfe, J.A.10
Tuttle, J.V.11
Miller, W.H.12
Condreay, L.13
Averett, D.R.14
Schinazi, R.F.15
Painter, G.R.16
-
15
-
-
0027417199
-
Affinity of the antiviral enantiomers of oxathiolane cytosine nucleosides for human 2′-deoxycytidine kinase
-
Shewach, D. S.; Liotta, D. C.; Schinazi, R. F. Affinity of the antiviral enantiomers of oxathiolane cytosine nucleosides for human 2′-deoxycytidine kinase. Biochem. Pharmacol. 1993, 45, 1540-1543.
-
(1993)
Biochem. Pharmacol.
, vol.45
, pp. 1540-1543
-
-
Shewach, D.S.1
Liotta, D.C.2
Schinazi, R.F.3
-
16
-
-
0027755282
-
Phosphorylation of the enantiomers of the carbocyclic analogue of 2′-deoxyguanosine in cells infected with herpes simplex virus type 1 and in uninfected cells. Lack of enantiomeric selectivity with the viral thymidine kinase
-
Bennett, L. L.; Parker, W. B.; Allan, P. W.; Rose, L. M.; Shealy, Y. F.; Secrist, J. A., III; Montgomery, J. A.; Arnett, G.; Kirkman, R. L.; Shannon, W. M. Phosphorylation of the enantiomers of the carbocyclic analogue of 2′-deoxyguanosine in cells infected with herpes simplex virus type 1 and in uninfected cells. Lack of enantiomeric selectivity with the viral thymidine kinase. Mol. Pharmacol. 1993, 44, 1258-1266.
-
(1993)
Mol. Pharmacol.
, vol.44
, pp. 1258-1266
-
-
Bennett, L.L.1
Parker, W.B.2
Allan, P.W.3
Rose, L.M.4
Shealy, Y.F.5
Secrist III, J.A.6
Montgomery, J.A.7
Arnett, G.8
Kirkman, R.L.9
Shannon, W.M.10
-
17
-
-
0030598664
-
Anti-human immunodeficiency and antihepatitis B virus activities of β-L-2′,3′-dideoxy purine nucleosides
-
Bolon, P. J.; Wang, P.; Chu, C. K.; Gosselin, G.; Boudou, V.; Pierra, C.; Mathé, C.; Imbach, J.-L.; Faraj, A.; El Alaoui, M. A.; Sommadossi, J.-P.; Pai, S. B.; Zhu, Y.-L.; Lin, J.-S.; Cheng, Y.-C.; Schinazi, R. F. Anti-human immunodeficiency and antihepatitis B virus activities of β-L-2′,3′-dideoxy purine nucleosides. Bioorg, Med. Chem. Lett. 1996, 6, 1657-1662.
-
(1996)
Bioorg, Med. Chem. Lett.
, vol.6
, pp. 1657-1662
-
-
Bolon, P.J.1
Wang, P.2
Chu, C.K.3
Gosselin, G.4
Boudou, V.5
Pierra, C.6
Mathé, C.7
Imbach, J.-L.8
Faraj, A.9
El Alaoui, M.A.10
Sommadossi, J.-P.11
Pai, S.B.12
Zhu, Y.-L.13
Lin, J.-S.14
Cheng, Y.-C.15
Schinazi, R.F.16
-
18
-
-
0028868671
-
Synthesis of a series of purine 2′,3′dideoxy-L-nucleoside analogues as potential antiviral agents
-
,18) Lin, T.-S.; Luo, M.-Z.; Zhu, J.-L.; Liu, M.-C.; Zhu, Y.-L.; Dutschman, G. E.; Cheng, Y.-C. Synthesis of a series of purine 2′,3′dideoxy-L-nucleoside analogues as potential antiviral agents. Nucleosides Nucleotides 1995, 14, 1759-1783.
-
(1995)
Nucleosides Nucleotides
, vol.14
, pp. 1759-1783
-
-
Lin, T.-S.1
Luo, M.-Z.2
Zhu, J.-L.3
Liu, M.-C.4
Zhu, Y.-L.5
Dutschman, G.E.6
Cheng, Y.-C.7
-
19
-
-
0024554252
-
General Syntheses of 2′,3′dideoxynucleosides and 2′,3′-didehydro-2′,3′-dideoxynucleosides
-
Chu, C. K.; Bhadti, V. S.; Doboszewski, B.; Gu, Z. P.; Kosugi, Y.; Pullaiah, K. C.; Van Roey, P. General Syntheses of 2′,3′dideoxynucleosides and 2′,3′-didehydro-2′,3′-dideoxynucleosides J. Org. Chem. 1989, 54, 2217-2225.
-
(1989)
J. Org. Chem.
, vol.54
, pp. 2217-2225
-
-
Chu, C.K.1
Bhadti, V.S.2
Doboszewski, B.3
Gu, Z.P.4
Kosugi, Y.5
Pullaiah, K.C.6
Van Roey, P.7
-
20
-
-
0024418643
-
4T) and 2′,3′-dideoxyadenosine (ddA): General methods for the synthesis of 2′,3′-olefinic and 2′,3′-dideoxy nucleoside analogues active against HIV
-
4T) and 2′,3′-dideoxyadenosine (ddA): General methods for the synthesis of 2′,3′-olefinic and 2′,3′-dideoxy nucleoside analogues active against HIV. J. Org. Chem. 1989, 54, 4780-4785.
-
(1989)
J. Org. Chem.
, vol.54
, pp. 4780-4785
-
-
Mansuri, M.M.1
Starrett, J.E.2
Wos, J.A.3
Tortolani, D.R.4
Brodfuehrer, P.R.5
Howell, H.G.6
Martin, J.C.7
-
21
-
-
0028327581
-
Intrinsic tryptophan fluorescence of bovine liver adenosine kinase, characterization of ligand binding sites and conformational changes
-
Elalaoui, A.; Divita, G.; Maury, G.; Imbach, J.-L.; Goody, R. S. Intrinsic tryptophan fluorescence of bovine liver adenosine kinase, characterization of ligand binding sites and conformational changes. Eur. J. Biochem. 1994, 221, 839-846.
-
(1994)
Eur. J. Biochem.
, vol.221
, pp. 839-846
-
-
Elalaoui, A.1
Divita, G.2
Maury, G.3
Imbach, J.-L.4
Goody, R.S.5
-
22
-
-
0025979756
-
Cloning and expression of human deoxycytidine kinase cDNA
-
Chottiner, E. G.; Shewach, D. S.; Datta, N. S.; Ashcraft, E.; Gribbin, D.; Ginsburg, D.; Fox, I. H.; Mitchell, B. S. Cloning and expression of human deoxycytidine kinase cDNA. Proc. Natl. Acad. Sci. U.S.A. 1991, 88, 1531-1535.
-
(1991)
Proc. Natl. Acad. Sci. U.S.A.
, vol.88
, pp. 1531-1535
-
-
Chottiner, E.G.1
Shewach, D.S.2
Datta, N.S.3
Ashcraft, E.4
Gribbin, D.5
Ginsburg, D.6
Fox, I.H.7
Mitchell, B.S.8
-
23
-
-
0030769662
-
The effects of high salt concentrations on the regulation of the substrate specificity of human recombinant deoxycytidine kinase
-
in press
-
Usova, E. V.; Eriksson, S. The effects of high salt concentrations on the regulation of the substrate specificity of human recombinant deoxycytidine kinase. Eur. J. Biochem. 1997, in press.
-
(1997)
Eur. J. Biochem.
-
-
Usova, E.V.1
Eriksson, S.2
-
24
-
-
0023808097
-
Metabolic pathways for the activation of the antiretroviral agent 2′,3′-dideoxyadenosine in human lymphoid cells
-
Johnson, M. A.; Ahluwalia, G.; Connelly, M. C.; Cooney, D. A.; Broder, S.; Johns, D. G.; Fridland, A. Metabolic pathways for the activation of the antiretroviral agent 2′,3′-dideoxyadenosine in human lymphoid cells. J. Biol. Chem. 1988, 263, 15354-15357.
-
(1988)
J. Biol. Chem.
, vol.263
, pp. 15354-15357
-
-
Johnson, M.A.1
Ahluwalia, G.2
Connelly, M.C.3
Cooney, D.A.4
Broder, S.5
Johns, D.G.6
Fridland, A.7
-
25
-
-
0023265911
-
The Anti-HTLV-III (anti-HIV) and cytotoxic activity of 2′,3′-didehydro-2′,3′-dideoxyribonucleosides: A comparison with their parental 2′,3′-dideoxyribonucleosides
-
Balzarini, J.; Kang, G.; Dalal, M.; Herdewijn, P.; De Clercq, E.; Broder, S.; Johns, D. G. The Anti-HTLV-III (anti-HIV) and cytotoxic activity of 2′,3′-didehydro-2′,3′-dideoxyribonucleosides: A comparison with their parental 2′,3′-dideoxyribonucleosides. Mol. Pharmacol. 1987, 32, 162-167.
-
(1987)
Mol. Pharmacol.
, vol.32
, pp. 162-167
-
-
Balzarini, J.1
Kang, G.2
Dalal, M.3
Herdewijn, P.4
De Clercq, E.5
Broder, S.6
Johns, D.G.7
-
26
-
-
0029162556
-
Mammalian deoxyribonucleoside kinases
-
Arner, E. S. J.; Erikson, S. Mammalian deoxyribonucleoside kinases. Pharmacol. Ther. 1995, 67, 155-186.
-
(1995)
Pharmacol. Ther.
, vol.67
, pp. 155-186
-
-
Arner, E.S.J.1
Erikson, S.2
-
27
-
-
0023228134
-
Initial studies on the cellular pharmacology of 2′,3′-dideoxyadenosine, an inhibitor of HT LV-III infectivity
-
Cooney, D. A.; Ahluwalia, G.; Mitsuya, H.; Fridland, A.; Johnson, M.; Hao, Z.; Dalal, M.; Balzarini, J.; Broder, S.; Johns, D. G. Initial studies on the cellular pharmacology of 2′,3′-dideoxyadenosine, an inhibitor of HT LV-III infectivity. Biochem. Pharmacol. 1987, 36, 1765-1768.
-
(1987)
Biochem. Pharmacol.
, vol.36
, pp. 1765-1768
-
-
Cooney, D.A.1
Ahluwalia, G.2
Mitsuya, H.3
Fridland, A.4
Johnson, M.5
Hao, Z.6
Dalal, M.7
Balzarini, J.8
Broder, S.9
Johns, D.G.10
-
28
-
-
0026561089
-
Interpretation of the roles of adenylosuccinate lyase and of AMP deaminase in the anti-HIV activity of 2′,3′-dideoxyadenosine and 2′,3′-dideoxyinosine
-
Nair, V.; Sells, T. B. Interpretation of the roles of adenylosuccinate lyase and of AMP deaminase in the anti-HIV activity of 2′,3′-dideoxyadenosine and 2′,3′-dideoxyinosine. Biochim. Biophys. Acta 1992, 1119, 201-204.
-
(1992)
Biochim. Biophys. Acta
, vol.1119
, pp. 201-204
-
-
Nair, V.1
Sells, T.B.2
-
29
-
-
15644384143
-
-
Unpublished results
-
Maury, G.; Gosselin, G.; Sommadossi, J.-P.; Imbach, J.-L.; Goody, R. S. Unpublished results.
-
-
-
Maury, G.1
Gosselin, G.2
Sommadossi, J.-P.3
Imbach, J.-L.4
Goody, R.S.5
-
30
-
-
0026331587
-
Inhibition and substrate specificity of adenosine deaminase. interaction with 2′-3′- And/or 5′-substituted adenine nucleoside derivatives
-
Maury, G.; Daiboun, T.; Elalaoui, A.; Genu-Dellac, C.; Perigaud, C.; Bergogne, C.; Gosselin, G.; Imbach, J.-L. Inhibition and substrate specificity of adenosine deaminase. interaction with 2′-3′- and/or 5′-substituted adenine nucleoside derivatives. Nucleosides Nucleotides 1991, 10, 1677-1692.
-
(1991)
Nucleosides Nucleotides
, vol.10
, pp. 1677-1692
-
-
Maury, G.1
Daiboun, T.2
Elalaoui, A.3
Genu-Dellac, C.4
Perigaud, C.5
Bergogne, C.6
Gosselin, G.7
Imbach, J.-L.8
|