Esophageal carcinogenesis in the rat: Zinc deficiency, dna methylation and alkyltransf erase activity

Pathobiology

Volumn 65, Issue 5, 1997, Pages 253-263

  Newbeme, Paul M ^a   Broitman, Selwyn ^a   Schrager, Thomas F ^a  

^a BOSTON MEDICAL CENTER   (United States)

Author keywords

Alkyltransferase; DNA methylation; Endophytic exophytic growth; Esophageal cancer; Parakeratosis; Zinc deficiency

Indexed keywords

6 O METHYLGUANINE; 7 METHYLGUANINE; DNA; DNA METHYLTRANSFERASE; N BENZYL N METHYLNITROSAMINE; ZINC;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARCINOGEN DNA INTERACTION; CARCINOGENESIS; CELL PROLIFERATION; CONTROLLED STUDY; DNA METHYLATION; DNA REPAIR; ENZYME ACTIVITY; ESOPHAGUS CANCER; ESOPHAGUS MUCOSA; MALE; NONHUMAN; PARAKERATOSIS; PRIORITY JOURNAL; RAT; TISSUE NECROSIS; ZINC DEFICIENCY;

ANIMALIA;

EID: 0030781802     PISSN: 10152008     EISSN: 14230291     Source Type: Journal    
DOI: 10.1159/000164136     Document Type: Article

References (22)

1. Wvnder E, Bross J: A study of etiological factors in cancer of the esophagus. Cancer 1961; 14:389-413.
2. Warwick GP. Harrington JS: Some aspects of epidemiology and etiology of esophageal cancer. Adv Cancer Res 1973;17:72-215.
3. Wvnder E: Epidemiology of cancers of the upper alimentary and upper respiratory tract. Laryngoscope 1987;88:50-51.
4. Yang CS: Research on esophageal cancer in China: A review. Cancer Res 1980:35:3493-3498.
5. Newbcme PM: Squamous carcinoma in the esophagus of the rat (zinc deficiency, alcohol, and methylbenzylnitrosamine); in Jones TC, Popp JA, Mohr U (cds): Monographs on Pathology of Laboratory Animals; Digestive System, cd 2. Berlin. Springer, 1997, pp 323-330.
6. Newberne PM, Schrager TF. Broitman S: Esophageal carcinogenesis in the rat: Zinc deficiency and alcohol effects on tumor induction. Pathobiology 1997:65:39-45.
7. National Research Council/National Academy of Sciences: Carcinogens and Anticarcinogens in the Human Diet. Washington, National Academy of Science, 1996. pp 141-143.
8. Dragan YP, Pitot HC: Aflatoxin carcinogenesis in the context of the multistage nature of cancer; in Eaton DL. Groopman JD (eds): The Toxicology of Aflatoxins. Orlando, Academic Press, 1994, pp 137-148.
9. Kumar V, Cotran RS, Stanley L: Basic Pathology, ed 5. Philadelphia, Saunders, 1992, pp 482-483.
10. Cardesa Antonio, Ovelar MY. Pera M: Squamous cell carcinoma, esophagus, rat; in Jones TC, Popp VA, Mohr U (eds): Monographs on Pathology of Laboratory Animals; Digestive System, cd 2. Berlin. Springer, 1997, pp 318-322.
11. Fong LYY, Sivak A. Newberne PM: Zinc deficiency and methylbcnzylnitrosaminc-induced esophageal cancer in rats. Natl Cancer Inst 1978;61:145-150.
12. Labuc GE, Archer MC: Esophageal and hepatic microsomal metabolism of MBN and DMN in the rat. Cancer Res 1982:42:2181-2186.
13. Gabriel GN, Schrager TF. Newbcme PM: Zinc deficiency, alcohol and a retinoid: Association with esophageal cancer in rats. J Natl Cancer Inst 1978;61:145-150.
14. Follis RH Jr: The pathology of zinc deficiency; in Prasad AS (ed): Zinc Metabolism. Spring-field, Thomas. 1966, pp 129-141.
15. Lin J, Chan WC, Fong LYY. Newberne PM: Zinc levels in serum, hair, and tumors from patients with esophageal cancer. Nutr Rep lnt 1977:15:635-643.
16. Fong LYY, Li Ji-Xai. Farbcr JL, Magee PN: Cell proliferation and esophageal carcinogenesis in the zinc deficient rat. Carcinogenesis 1996;17:1841-1848.
17. Hart RW, Newmann DA, Robertson RT (eds): Dietary Restrictions: Implications for the Design and Interpretation of Toxicity and Carcinogenicity Studies. Washington, ILSI Press, 1994, p 396.
18. Newberne PM, Sotnikov AV: Diet: The neglected variable in chemical safety evaluations. Toxicol Pathol 1996;24:746-756.
19. Newberne PM, Punyarit P, de Camargo J, Su-phakam V: The role of necrosis in hepatocellular proliferation and livertumors. Arch Toxicol Suppl 1987;10:3-9.
20. Shin DM. Kim J, Ro JY, Hitteleman J, Roth JA. Waun KH. Hittleman W: Activation of p53 gene expression in premalignant lesions during head and neck tumorigenesis. Cancer Res 1994:54:321-326.
21. Zhaoming X, Squires EJ, Bray TM: Effects of dietary zinc deficiency on the expression of hepatic microsomal cytochrome P4503EI in rats. J NulrBiochem 1994:5:308-313.
22. Walsh CT, Sandstead HH, Prasad AS. New-beme PM. Fraker PJ: Zinc: Health effects and research priorities for the 1990’s. Environ Health Perspect 1994;102:5-46.