Early, short-term treatment with captopril permanently attenuates cardiovascular changes in spontaneously hypertensive rats

Clinical and Experimental Hypertension

Volumn 19, Issue 8, 1997, Pages 1161-1177

  Regan, Christopher P ^a   Bishop, Sanford P ^a   Berecek, Kathleen H ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Angiotensin converting enzyme; Angiotensin II; Cardiovascular remodeling; Hypertension; Spontaneously hypertensive rat

Indexed keywords

CAPTOPRIL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CARDIOVASCULAR RESPONSE; DRUG MECHANISM; ENZYME INHIBITION; HEART VENTRICLE REMODELING; HYPERTENSION; MEAN ARTERIAL PRESSURE; NONHUMAN; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM;

EID: 0030781605     PISSN: 10641963     EISSN: None     Source Type: Journal    
DOI: 10.3109/10641969709083210     Document Type: Article

References (26)

1. Dal Palu, C., Magnai, B., Zanchetti, Z., eds. Hypertension; Organ damage and ACE inhibition. J Cardiovasc Pharmacol. 1993; 22 (Suppl. 1).
2. Weber, K., Sun, Y , Tyagi, S., Cleutjens, J. Collagen network of the myocardium: function, structural remodeling, and regulatory mechanisms. J Mol Cell Cardiol. 1994; 26: 279-292.
3. Weber, K., Janicki, J., Pick, R., Capasso, J., Anversa, P Myocardial fibrosis and pathologic hypertrophy in the rat with renovascular hypertension. Am J Cardiol. 1990; 65: 66-76
4. Owens, G. K. Influence of blood pressure on development of aortic medial smooth muscle hypertrophy in spontaneously hypertensive rats. Hypertension Dallas. 1987; 9 (2): 178-87.
5. Cohn, J., Johnson, G., Ziesche, S., Cobb, F., Francis, G., Tristani, F., Smith, R, Dunkman, B., Loeb, H., Wong, M., Bhat, G., Goldman, S., Fletcher, R., Doherty, J., Hughes, C., Carson, P., Cintron, G., Shabetai, R., Haakenson, C. A comparison of enalapril with hydralazine-isosorbide dinitrate in the treatment of chronic congestive heart failure. N Engl J Med. 1991; 325: 303-310.
6. Wu, J., Berecek, K. Prevention of genetic hypertension by early treatment of spontaneously hypertensive rats with angiotensin converting enzyme inhibitor captopril. Hypertension Dallas. 1993; 22: 139-146.
7. Giudicelli, J., Freslon, J., Glasson, S., Richer, C. Captopril and hypertension: development in the SHR Clin Exp Hypertens. 1980; 2: 1083-1093.
8. Harrap, S., Walter, M., Merwe, V. d., Griffin, S., Macpherson, F., Lever, A. Brief angiotensin converting enzyme inhibitor treatment in young spontaneously hypertensive rats reduces blood pressure long-term. Hypertension Dallas. 1990; 16: 603-614
9. Linz, W., Scholkens, B., Ganten, D. Converting enzyme inhibition specifically prevents the development and induces the regression of cardiac hypertrophy in rats. Clin Exp Hypertens. 1989; 11: 1325-1350.
10. Brilla, C. G., Janicki, J. S., Weber, K. T. Impaired diastolic function and coronary reserve in genetic hypertension. Role of interstitial fibrosis and medial thickening of intramyocardial coronary arteries. Circ Res. 1991; 69 (1): 107-15.
11. Regan, C., Anderson, P., Bishop, S., Berecek, K. Captopril prevents vascular and fibrotic changes but not cardiac hypertrophy in aortic-banded rats. Am J Physiol. 1996; 271 (40): H906-H913
12. Anderson, P., Bishop, S, Digerness, S. Vascular remodeling and improvement of coronary reserve after hydralazine treatment in spontaneously hypertensive rats. Circ Res. 1989; 64: 1127-1136.
13. Walter, S. V., Hamet, P. Enhanced DNA synthesis in heart and kidney of newborn spontaneously hypertensive rats. Hypertension Dallas. 1986; 8 (6): 520-5.
14. Eccleston-Joyner, C., Gray, S Arterial hypertrophy in the fetal and neonatal spontaneously hypertensive rat. Hypertension Dallas. 1988; 12 513-518.
15. Traub, O., Lloyd, M., Webb, R. Long-term effects of brief antihypertensive treatment on systolic blood pressure and vascular reactivity in young genetically hypertensive rats. Cardiovasc Drugs Ther. 1995; 9: 421-429.
16. Mortoa, J., Beattie, E., MacPherson, F. Angiotensin n receptor antagonist losartan has persistent effects on blood pressure in the young spontaneously hypertensive rat: lack of relation to vascular structure. J Vasc Res. 1992; 29: 264-269.
17. Clozel, J., Veniant, M., Hess, P., Sprecher, U. Effects of two angiotensin converting enzyme inhibitors and hydralazine on coronary circulation in hypertensive rats. Hypertension Dallas. 1991; 18 (suppl. II): II8-II14.
18. Griffin, S., Brown, W., MacPherson, F., McGrath, L., Wilson, V., Korsgaard, N., Mulvany, M., Lever, A. Angiotensin II causes vascular hypertrophy in part by a non-pressor mechanism. Hypertension Dallas. 1991; 17 (5): 626-635.
19. Soltis, E. Alterations in vascular structure and function after short term losartan treatment in spontaneously hypertensive rats. J Phramacol Exp Ther. 1993; 266 (2): 642-646.
20. Geisterfer, A., Peach, M., Owens, G. Angiotensin II induces hypertrophy, not hyperplasia, of cultured rat aortic smooth muscle cells. Circ Res. 1988; 62: 749-756.
21. Kato, H., Suzuki, H., Tajima, S., Ogata, Y., Tominaga, T., Sato, A., Saruta, T. Angiotensin II stimulates collagen synthesis in cultured vascular smooth muscle cells. J Hypertens. 1991; 9: 17-22.
22. 1 receptor. J Hypertens. 1992; 10 (12): 1463-1469.
23. Morgan, H. E., Baker, K. M. Cardiac hypertrophy. Mechanical, neural, and endocrine dependence. Circulation. 1991; 83 (1): 13-25.
24. Golomb, E , Abassi, Z., Cuda, G., Stylianou, M., Panchal, V., Trachewsky, D., Keiser, H. Angiotensin II maintains, but does not mediate, isoproterenol-induced cardiac hypertrophy in rats. Am J Physiol. 1994; 267 (36): H1496-H1506.
25. Castellano, M., Rizzoni, D., Beschi, M., Bohm, M., Porteri, E., Bettoni, G., Cinelli, A., Rosei, E. Chronic ACE-inhibitor treatment and adrenergic mechanisms in spontaneously hypertensive rats. J Cardiovasc Pharmacol. 1995; 26: 381-387.
26. Gohlke, P., Linz, W., Scholkens, B., Kuiver, I., Bartenbach, S., Schnell, A., Unger, T. Angiotensin converting enzyme inhibition improves cardiac function: role of bradykinin. Hypertension Dallas. 1994; 23: 411-418.