Treatment of methanol poisoning with intravenous 4-methylpyrazole

Annals of Emergency Medicine

Volumn 30, Issue 6, 1997, Pages 829-832

  Burns, M J ^a   Graudins, A ^a   Aaron, C K ^a   McMartin, K ^a   Brent, J ^a  

^a Department of Emergency Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 METHYLPYRAZOLE; ALCOHOL; ALCOHOL DEHYDROGENASE; ETHYLENE GLYCOL; FORMIC ACID; METHANOL; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CASE REPORT; CLINICAL TRIAL; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MALE; METHANOL POISONING; ORAL DRUG ADMINISTRATION; PHASE 3 CLINICAL TRIAL; PRIORITY JOURNAL; TOXICOKINETICS;

EID: 0030781571     PISSN: 01960644     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0196-0644(97)70060-X     Document Type: Article

References (18)

1. D Jacobsen KE McMartin Methanol and ethylene glycol poisonings: Mechanism of toxicity, clinical course, diagnosis and treatment Med Toxicol 1 1986 309 334
2. KE McMartin JJ Ambre TR Tephly Methanol poisoning in human subjects: role for formic acid accumulation in the metabolic acidosis Am J Med 68 1980 414 418
3. KE McMartin AB Makar M Palese Methanol poisoning I. The role of formic acid in the development of metabolic acidosis in the monkey and reversal by 4-methylpyrazole Biochem Med 13 1975 319 333
4. KE McMartin K-G Hedstrom B-R Tolf Studies on the metabolic interactions between 4-methylpyrazole and methanol using the monkey as an animal model Arch Biochem Biophys 199 1980 606 614
5. GF Grauer MAH Thrall BA Henre Comparison of the effects of ethanol and 4-methylpyrazole on the pharmacokinetics and toxicity of ethylene glycol in the dog Toxicol Lett 35 1987 307 314
6. FJ Baud C Bismuth R Garnier 4-methylpyrazole may be an alternative to ethanol therapy for ethylene glycol intoxication in man Clin Toxicol 24 1986-7 463 483
7. FJ Baud M Galliot A Astier Treatment of ethylene glycol poisoning with intravenous 4-methylpyrazole N Engl J Med 319 1988 97 100
8. P Harry A Turcant G Bouachour Efficacy of 4-methylpyrazole in ethylene glycol poisoning: Clinical and toxicokinetic aspects Hum Exp Toxicol 13 1994 61 64
9. RN Baker AL Alenty JF Zack Jr Simultaneous determination of lower alcohols, acetone and acetaldehyde in blood gas chromatography J Chromatogr Sci 7 1969 312 314
10. AB Makar TR Tephly Improved estimation of formate in body fluids Clin Chem 28 1982 385
11. D Jacobsen CS Sebastian DF Dies Kinetic interactions between 4-methylpyrazole and ethanol in healthy humans Alcohol Clin Exp Res 20 1996 804 809
12. R Blomstrand H Theorell Inhibitory effect on ethanol oxidation in man after administration of 4-methylpyrazole Life Sci II 9 1970 631 640
13. D Jacobsen S Sebastian SK Barron Effects of 4-methylpyrazole, methanol/ethylene glycol antidote, in healthy humans J Emerg Med 8 1990 455 461
14. D Jacobsen CS Sebastian R Blomstrand 4-methylpyrazole: A controlled study of safety in healthy human subjects after single, ascending doses Alcohol Clin Exp Res 12 1988 516 522
15. R Pietruszko Human liver alcohol dehydrogenase: Inhibition of methanol activity by pyrazole, 4-methylpyrazole, 4-hydroxymethylpyrazole and 4-carboxypyrazole Biochem Pharmacol 24 1975 1603 1607
16. PE Noker JT Eells TR Tephly Methanol toxicity: Treatment with folic acid and 5-formyl-tetrahydrofolic acid Alcohol Clin Exp Res 4 1980 378 383
17. W Palatnick LW Redman DS Sitar Methanol half-life during ethanol administration: Implications for management of methanol poisoning Ann Emerg Med 26 1995 202 207
18. D Jacobsen R Webb TD Collins Methanol and formate kinetics in late diagnosed methanol intoxication Med Toxicol 3 1988 418 423