Effects of the novel dual inhibitor of neutral endopeptidase and angiotensin-converting enzyme, CGS 30440, on blood pressure and cardiac hypertrophy in spontaneously hypertensive rats

Journal of Cardiovascular Pharmacology

Volumn 30, Issue 5, 1997, Pages 632-642

  Webb, R L ^a   Abramson, M L ^a   Beil, M E ^a   Odorico, L M ^a   Chatelain, R E ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

ACE NEP inhibitor; Angiotensin converting enzyme; CGS 30440; Left ventricular hypertrophy; Neutral endopeptidase

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENKEPHALINASE INHIBITOR; N [[1 (2 ACETYLTHIO 3 METHYL 1 OXOBUTYLAMINO) 1 CYCLOPENTYL]CARBONYL] O METHYLTYROSINE ETHYL ESTER; N [[1 [(2 ACETYLTHIO 3 METHYL 1 OXOBUTYL)AMINO] 1 CYCLOPENTYL]CARBONYL] O METHYLTYROSINE ETHYL ESTER; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANTIHYPERTENSIVE THERAPY; ARTICLE; DRUG EFFECT; DRUG POTENCY; HEART HEMODYNAMICS; HYPERTENSION; NONHUMAN; PRIORITY JOURNAL; RAT; SPONTANEOUSLY HYPERTENSIVE RAT;

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; CARDIOMEGALY; CYCLIC GMP; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HEART RATE; HYPERTENSION; KIDNEY; NEPRILYSIN; PEPTIDYL-DIPEPTIDASE A; RATS; RATS, INBRED SHR; RATS, INBRED WKY; TYROSINE; URINATION; WEIGHT GAIN;

EID: 0030781169     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199711000-00014     Document Type: Article

References (38)