Hyperlipidemia enhancement of renal preneoplasia but not tumor formation is due to elevated apoptosis in the Eker rat

Cancer Research

Volumn 57, Issue 21, 1997, Pages 4673-4676

  Miki, Shunji ^a   Miki, Yoshitsugu ^b   Mitani, Hiroaki ^c   Sato, Bunzo ^a   Yamamoto, Masahiro ^a   Hino, Okio ^c  

^a Nissei Hospital   (Japan)

^b Miki Clinic   (Japan)

^c CANCER INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; DIETARY INTAKE; FAMILIAL CANCER; FAT INTAKE; FEMALE; HISTOCHEMISTRY; HYPERLIPIDEMIA; KIDNEY ADENOMA; KIDNEY CANCER; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TRANSMISSION ELECTRON MICROSCOPY; TUMOR GROWTH;

ADENOMA; ANIMALS; APOPTOSIS; BODY WEIGHT; CARCINOMA, RENAL CELL; DIET, FAT-RESTRICTED; DIETARY FATS; KIDNEY NEOPLASMS; LIPOPROTEINS, LDL; MALE; RATS; TUMOR CELLS, CULTURED;

EID: 0030781046     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. MacDougall, M. L., Welling, L. W., and Wiegmann, T. B. Renal adenocarcinoma and acquired cystic disease in chronic hemodialysis patients. Am. J. Kidney Dis., 9: 166-371, 1987.
2. Wynder, E. L., Mabuchi, K., and Whitemore, W. F. Epidemiology of adenocarcinoma of the kidney. J. Natl. Cancer Inst., 53: 1619-1634, 1974.
3. Miki, S., Matsumoto, A., Nakamura, Y., Itakura, H., Kodama, T., Yamamoto, M., and Miki, Y. Expression of scavenger receptors on renal cell carcinoma cells in vitro. Biochem. Biophys. Res. Commun., 189: 1323-1328, 1992.
4. Miki, S., Kasayama, S., Miki, Y., Naamura, Y., Yamamoto, M., Sato, B., and Kishimoto, T. Expression of receptors for advanced glycosylation end products on renal cell carcinoma cells in vitro. Biochem. Biophys. Res. Commun., 196: 984-989, 1993.
5. Miki, S., Iwano, M., Miki, Y., Yamamoto, M., Tang, B., Yokokawa, K., Sonoda, T., Hirano, T., and Kishimoto, T. Interleukin-6 (IL-6) functions as an in vitro autocrine growth factor in renal cell carcinomas. FEBS Lett., 250: 607-610, 1989.
6. Eker, R., Mossige, L., Johannessen, J. V., and Aars, H. Hereditary renal adenomas and adenocarcinomas in rats. Diagn. Histopathol., 4: 99-110, 1981.
7. Hino, O., Klein-Szanto, A. J. P., Freed, J. J., Testa, J. R., Brown, D. Q., Vilensky, M., Yeung, R. S., Tartof, K. D., and Knudson, A. G. Spontaneous and radiation-induced renal tumors in the Eker rat model of dominantly inherited cancer. Proc. Natl. Acad. Sci. USA, 90: 327-331, 1993.
8. Kobayashi, T., Hirayama, Y., Kobayashi, E., Kubo, Y., and Hino, O. A germ line insertion in the tuberous sclerosis (Tsc2) gene gives rise to the Eker rat model of dominantly inherited cancer. Nat. Genet., 9: 70-74, 1995.
9. Kobayashi, T., Mitani, H., Takahashi, R., Hirabayashi, M., Ueda, M., Tamura, H., and Hino, O. Transgenic rescue from embryonic lethality and renal carcinogenesis in the Eker rat model by introduction of a wild-type Tsc2 gene. Proc. Natl. Acad. Sci. USA, 94: 3990-3993, 1997.
10. Chuman, L., Fine, L. G., Cohen, A. H., and Saier, M. H., Jr. Continuous growth of proximal lubulur kidney epithelial cells in hormone-supplemented serum-free medium. J. Cell Biol., 94: 506-510, 1982.
11. Ashkenas, J. Penman, M., Vasile, E. Acton S., Freeman, M., and Krieger, M. Structures and high and low affinity ligand binding properties of murine type 1 and type 2 macrophage scavenger receptors. J. Lipid Res., 34: 983-1000, 1993.
12. Miki, S., Tsukada, S., Nakamura, Y., Aimoto, S., Hojo, H., Sato, B., Yamamoto, M., and Miki, Y. Functional and possible physical association of scavenger receptor with cytoplasmic tyrosine kinase lyn in monocytic THP-1-derived macrophages. FEBS Lett., 399: 241-244, 1996.
13. Lu, C., and Tanigawa, N. Spontaneous apoplosis is inversely related to intratumoral microvessel density in gastric carcinoma. Cancer Res., 57: 221-224, 1997.
14. Kasiske, B. L., O'Donnel, M. P., Schmitz, P. G., Kim, Y., and Keane, W. F. Renal injury of diet-induced hypercholesterolemia in rats. Kidney Int., 37: 880-891, 1990.
15. Miki, S. Yamada, H., Orita, T., Yamamoto, M., and Miki, Y. Suicide process of renal cell carcinoma cells encountering mumps virus. FEBS Lett., 278: 179-182, 1991.
16. Hegyi, L., Skepper, J. N., Cary, N. R., and Mitchinson, M. J. Foam cell apoptosis and the development of the lipid core of human atherosclerosis. J. Pathol., 180: 423-429, 1996.
17. Sharma, P. Native and oxidized low density lipoproteins modulate mesangial cell apoptosis. Kidney Int., 50: 1604-1611, 1996.
18. Ortiz-Arduan, A., Danoff, T. M., Kalluri, R., Gonzalez-Cuadrado, S., Karp, S. L., Elkon, K., Egido, J., and Neilson, E. G. Regulation of Fas and Fas ligand expression in cultured murine renal cells and in the kidney during endotoxemia. Am. J. Physiol., 271: 1193-1201, 1996.
19. Kubo, Y., K;imek, F., Kikuchi, Y., Bannasch, P., and Hino, O. Early detection of Knudson's two-hits in preneoplastic renal cells of the Eker rat model by laser microdissection procedure. Cancer Res., 55: 989-990, 1995.