Sensitive detection of growth stimulating tumour promoters in perifused primary rat hepatocyte cultures

Toxicology in Vitro

Volumn 11, Issue 5, 1997, Pages 543-547

  Klein, S ^a   Gebhardt, R ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; CARCINOGEN; CLOFIBRATE; CYPROTERONE ACETATE; DIELDRIN; LINDANE; METHYLNITRONITROSOGUANIDINE; NAPHTHOL DERIVATIVE; TUMOR PROMOTER;

ANIMAL CELL; ARTICLE; BIOTRANSFORMATION; CELL GROWTH; CULTURE MEDIUM; DNA SYNTHESIS; GROWTH INHIBITION; LIVER CELL CULTURE; MALE; NONHUMAN; RAT; SIGNAL TRANSDUCTION; STEADY STATE;

ANIMALIA;

EID: 0030780471     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0887-2333(97)00063-5     Document Type: Article

References (26)

1. Farber E., Solt D., Cameron R., Laishes B., Ogawa K. and Medline A. (1977) Newer insights into the pathogenesis of liver cancer. American Journal of Pathology 89, 477-482.
2. Gebhardt R. (1994) Improved drug metabolizing capacity of hepatocytes co-cultured with epithelial cells and maintained in a perifusion system. In Alternatives to Animal Testing. Edited by C. Reinhard, pp. 141-146. Verlag Chemie, Weinheim.
3. Gebhardt R. and Fischer S. (1995) Enhanced sensitivity of perifused primary rat hepatocytes to mitogens and growth modulation by carcinogens. Toxicology in Vitro 9, 445-451.
4. Gebhardt R. and Mecke D. (1979) Perifused monolayer cultures of rat hepatocytes as an improved in vitro system for studies on ureogenesis. Experimental Cell Research 124, 349-359.
5. Gebhardt R., Wegner H. and Alber J. (1996) Perifusion of cocultured hepatocytes: optimization of studies on drug metabolism and cytotoxicity in vitro. Cell Biology and Toxicology 12, 57-68.
6. Levin W. G., Ord M. G. and Stocken L. A. (1977) Some biochemical changes associated with nafenopin-induced liver growth in the rat. Biochemical Pharmacology 26, 939-942.
7. McGowan J. A. (1986) Hepatocyte proliferation in culture. In Research in Isolated and Cultured Hepatocytes. Edited by A. Guillouzo and C. Guguen-Guillouzo. pp. 13-38. Inserm, Paris, and John Libbey Eurotext, Montrouge.
8. Martelli A., Mattioli F., Fazio S., Andrae U. and Brambilla G. (1995) DNA repair synthesis and DNA fragmentation in primary cultures of human and rat hepatocytes exposed to cyproterone acetate. Carcinogenesis 16, 1265-1269.
9. Michalopoulos G. K. (1990) Lever regeneration: molecular mechanisms of growth control. FASEB Journal 4, 176-187.
10. Moore M. A. and Kitagawa T. (1986) Hepatocarcinogenesis in the rat: the effect of promoters and carcinogens in vivo and in vitro. International Review of Cytology 101, 125-173.
11. Murray A. W., Edwards A. M. and Hu C. S. T. (1989) Tumour promotion: biology and molecular mechanisms. In Carcinogenesis and Mutagenesis. Edited by P. L. Grover and C. S. Cooper. pp. 133-157. Springer, Berlin.
12. Nakamura T., Arakaki R. and Ichihara A. (1988) Interleukin-1 is a potent growth inhibitor of adult rat hepatocytes in primary culture. Experimental Cell Research 179, 488-497.
13. Neumann I., Thierau D., Andrae U., Greim H. and Schwarz L. R. (1992) Cyproterone acetate induces DNA damage in cultured rat hepatocytes and preferentially stimulates DNA synthesis in gamma-glutamyltranspeptidase-positive cells. Carcinogenesis 13, 373-378.
14. Novicki D. L., Rosenberg M. R. and Michalopoulos G. (1985) Inhibition of DNA synthesis by chemical carcinogens in cultures of initiated and normal proliferating rat hepatocytes. Cancer Research 45, 337-344.
15. Oberhammer F. A. and Qin H. M. (1995) Effect of three tumour promoters on the stability of hepatocyte cultures and apoptosis after transforming growth factor-beta 1. Carcinogenesis 16, 1363-1371.
16. Parzefall W., Galle P. R. and Schulte-Hermann R. (1985) Effect of calf and rat serum on the induction of DNA synthesis and mitosis in primary cultures of adult rat hepatocytes by cyproterone acetate and epidermal growth factor. In Vitro Cellular and Developmental Biology 21, 665-673.
17. Parzefall W., Monschau P. and Schulte-Hermann R. (1989) Induction by cyproterone acetate of DNA synthesis and mitosis in primary cultures of adult rat hepatocytes in serum free medium. Archives of Toxicology 63, 456-461.
18. Schulte-Hermann R. (1974) Induction of liver growth by xenobiotic compounds and other stimuli. Critical Reviews in Toxicology 3, 97-158.
19. Schulte-Hermann R. (1978) Two-stage control of cell proliferation induced in rat liver by hexachlorocyclohexane. Cancer Research 37, 166-171.
20. Schulte-Hermann R., Hoffmann V., Parzefall W., Kallenbach M., Gerhardt A. and Schuppler J. (1980) Adaptive responses of rat liver to the gestagen and anti-androgen cyproterone acetate and other inducers II. Induction of growth. Chemico-Biological Interactions 31, 287-300.
21. Schulte-Hermann R., Ohde G., Schuppler J. and Timmermann-Trosiener I. (1981) Enhanced proliferation of putative preneoplastic cells in rat liver following treatment with the tumour promoters phenobarbital, hexachlorocyclohexane, steroid compounds, and nafenopin. Cancer Research 41, 2556-2562.
22. Stinchcombe S., Buchmann A., Bock K. W. and Schwarz M. (1995) Inhibition of apoptosis during 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated tumour promotion in rat liver. Carcinogenesis 16, 1271-1275.
23. Thottassery J. V. and Yarbrough J. D. (1991) Regulation of glucocorticoid receptors during adaptive liver growth. American Journal of Physiology 260, G603-G609.
24. Volk A., Michalopoulos G., Weidner M. and Gebhardt R (1995) Different proliferative response of periportal and pericentral rat hepatocytes to hepatocyte growth factor Biochemical and Biophysical Research Communications 207, 578-584.
25. Yarbrough J. D., Grimley J. M. and Thottassery J. V. (1992) Mirex-induced adaptive liver growth in rats subjected to thyroidectomy. Hepatology 15, 923-927.
26. Yusof Y. A. M. and Edwards A. M. (1990) Stimulation of DNA synthesis in primary rat hepatocyte cultures by liver tumour promoters: interaction with other growth factors. Carcinogenesis 11, 761-770.