Inhibitory effect of lomerizine, a diphenylpiperazine Ca2+-channel blocker, on Ba2+ current through voltage-gated Ca2+ channels in PC12 cells

Japanese Journal of Pharmacology

Volumn 75, Issue 2, 1997, Pages 209-213

  Watano, Tomokazu ^a   Hara, Hideaki ^a   Sukamoto, Takayuki ^a  

^a KANEBO LTD   (Japan)

Author keywords

Lomerizine; PC12 cell; Voltage gated Ca2+ channel

Indexed keywords

BARIUM ION; CALCIUM CHANNEL; DILTIAZEM; DIMETOTIAZINE; FLUNARIZINE; LOMERIZINE; NICARDIPINE; VERAPAMIL; VOLTAGE GATED CHANNEL FORMING PROTEIN;

ARTICLE; CELL MEMBRANE POTENTIAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; HUMAN; HUMAN CELL; MEMBRANE CURRENT; PHEOCHROMOCYTOMA CELL; VOLTAGE CLAMP;

EID: 0030779767     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.75.209     Document Type: Article

References (18)

1. Godfraind T, Miller R and Wibo M: Calcium antagonism and calcium entry blockade. Pharmacol Rev 38, 321-416 (1986)
2. 3H]nitrendipine binding. Jpn J Pharmacol 48, 241-247 (1988)
3. Iwamoto T, Morita T and Sukamoto T: Calcium antagonism by KB-2796, a new diphenylpiperazine analogue, in dog vascular smooth muscle. J Pharm Pharmacol 43, 535-539 (1991)
4. 2+ currents and oxidative metabolism in dissociated mammalian CNS neurons. Brain Res 619, 263-270 (1993)
5. Gotoh F, Fukuuchi Y, Tashiro K, Katsuzawa N, Katayama S, Hirai S, Otomo E, Kito S, Terashi A, Tazaki Y, Sakai F, Ito E, Takahashi A, Sawada T, Takayanagi T, Takahashi K, Fujishima M and Goto I: Clinical evaluation of KB-2796 on migraine -double-blind study in comparison with dimetotiazine-. Clin Eval 23, 183-214 (1995) (Abstr in English)
6. Hara H, Morita T, Sukamoto T and Cutrer FM: Lomerizine (KB-2796), a new antimigraine drug. CNS Drug Rev 1, 204-226 (1995)
7. Inoue K and Kenimer JG: Muscarinic stimulation of calcium influx and norepinephrine release in PC12 cells. J Biol Chem 263, 8157-8161 (1988)
8. Hamill OP, Marty A, Neher E, Sakmann B and Sigworth FJ: Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch 391, 85-100 (1981)
9. Nakazawa K, Inoue K, Ohara-Imaizumi M, Fujimori K and Takanaka A: Inhibition of Ca-channels by diazepam compared with that by nicardipine in pheochromocytoma PC12 cells. Brain Res 553, 44-50 (1991)
10. 2+ channel current in PC12 cells. Eur J Pharmacol 314, 143-150 (1996)
11. Tsien RW, Lipscombe D, Madison DV, Bley KR and Fox AP: Multiple types of neuronal calcium channels and their selective modulation. Trends Neurosci 11, 431-438 (1988)
12. 2+ channels in PC12 cells. J Neurosci 16, 7557-7565 (1996)
13. 2+ channels in rat phaeochromocytoma cell lines. J Physiol (Lond) 426, 95-116 (1990)
14. Triggle DJ: Calcium-channel drugs: structure-function relationships and selectivity of action. J Cardiovasc Pharmacol 18, S1-S6 (1991)
15. Hess P, Lansman JB and Tsien RW: Different modes of Ca channel gating behaviour favoured by dihydropyridine Ca agonists and antagonists. Nature 311, 538-544 (1984)
16. Friedman ME, Suarez Kurtz G, Kaczorowski GJ, Katz GM and Reuben JP: Two calcium currents in a smooth muscle cell line. Am J Physiol 250, H699-H703 (1986)
17. Toda N and Tfelt-Hansen P: Calcium antagonists. In The Headaches, Edited by Olesen Jm Tfelt-Hansen P and Welch KMA, pp 383-390, Raven Press, New York (1993)
18. Leandri M, Rigardo S, Schizzi R and Parodi CI: Migraine treatment with nicardipine. Cephalalgia 10, 11-116 (1990)