Gabapentin for the treatment of spasticity in patients with spinal cord injury

Spinal Cord

Volumn 35, Issue 10, 1997, Pages 686-689

  Gruenthal, M ^a   Mueller, M ^a   Olson, W L ^a   Priebe, M M ^b   Sherwood, A M ^b   Olson, W H ^a  

^a University of Louisville School of Medicine   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Gabapentin; Spasticity; Spinal cord injury

Indexed keywords

ANTICONVULSIVE AGENT; GABAPENTIN;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CLONUS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG ACTIVITY; FEMALE; HUMAN; MALE; MYOTATIC REFLEX; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REFLEX; SPASTICITY; SPINAL CORD INJURY;

EID: 0030779728     PISSN: 13624393     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.sc.3100481     Document Type: Article

References (17)

1. Maynard FM, Karunas RS, Waring WP. Epidemiology of spasticity following traumatic spinal cord inury. Arch Phys Med Rehabil 1990; 71: 566-569.
2. Hattab JR. Review of european clinical trials with baclofen. In: Feldman RG, Young RR, Koella WP (eds.). Spasticity: Disrodered motor control. Chicago: Year Book Medical Publishers, 1979; 71-85.
3. Chyatte SB, Basmajian JV. Dantrolene Sodium: Long-term effects in severe spasticity. Arch Phys Med Rehabil 1973; 54: 311-315.
4. Nance PW, Shears AH, Nance DM. Reflex changes induced by clonidine in spinal cord injured patients. Paraplegia 1989; 27: 296-301.
5. Levine IM, Jossmann PB, DeAngelis V. Lioresal, a new muscle relaxant in the treatment of spasticity - A double-blind quantitative evaluation. Dis Nerv Syst 1977; 38: 1011-1015.
6. Joynt RL. Dantrolene sodium: Long-term effects in patients with muscle spasticity. Arch Phys Med Rehabil 1976; 57: 212-217.
7. Corston RN, Johnson F, Godwin-Austen RB. The assessment of drug treatment of spastic gait. J Neurol Neurosurg Psychiatry 1981; 44: 1035-1039.
8. Nance PW et al. Efficacy and safety of tizanidine in the treatment of spasticity in patients with spinal cord injury. Neurology 1994; 44: S44-S52.
9. Penn RD et al. Intrathecal baclofen for severe spinal spasticity. N Engl J Med 1989; 320: 1517-1521.
10. Coffey RJ et al. Intrathecal baclofen for intractable spasticity of spinal origin: results of a long-term multicenter study. J Neurosurg 1993; 78: 26-32.
11. Loubser PG et al. Continuous infusion of intrathecal baclofen: Long-term effects on spasticity in spinal cord injury. Paraplegia 1991; 29: 48-64.
12. McLean MJ. Gabapentin. Epilepsia 1995; 36: S73-S86.
13. McLean MJ. Clinical pharmacokinetics of gabapentin. Neurology 1994; S17-S22.
14. Handforth A, Treiman DM. Efficacy and tolerance of long-term, high-dose gabapentin: Additional observations. Epilepsia 1994; 35: 1032-1037.
15. 3H]gabapentin to a novel site in rat brain: autoradiographic studies. Eur J Pharmacol 1993; 244: 303-309.
16. 3H]gabapentin binding to a novel site in rat brain: homogenate binding studies. Eur J Pharmacol 1993; 344: 293-301.
17. Löscher W, Honack D, Taylor CP. Gabapentin increases aminooxyacetic acid-induced GABA accumulation in several regions of rat brain. Neurosci Lett 1991; 128: 150-154.