Does phosphodiesterase III inhibition reverse the cardiodepressive effects of propofol?

Anesthesia and Analgesia

Volumn 85, Issue 4, 1997, Pages 725-728

  Pernerstorfer, Thomas ^a,b   Mayer, Nikolaus ^a   Jilma, Bernd ^a   Krenn, Claus Georg ^a   Bayer, Gottfried Sebastian ^a   Eichler, Hans Georg ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ENOXIMONE; FENTANYL; MIDAZOLAM; NITROUS OXIDE; PHOSPHODIESTERASE INHIBITOR; PROPOFOL; VECURONIUM;

ADULT; AGED; ARTICLE; CARDIOVASCULAR FUNCTION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; HEART INDEX; HEART RATE; HEART STROKE VOLUME; HUMAN; INTRAVENOUS ANESTHESIA; INTRAVENOUS DRUG ADMINISTRATION; MALE; MEAN ARTERIAL PRESSURE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ADULT; AGED; BLOOD PRESSURE; DEPRESSION, CHEMICAL; DOUBLE-BLIND METHOD; ENOXIMONE; FEMALE; HEART; HUMANS; MALE; MIDDLE AGED; PHOSPHODIESTERASE INHIBITORS; PROPOFOL;

EID: 0030779131     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000539-199710000-00003     Document Type: Article

References (27)

1. Sebel PS, Lowdon JD. Propofol: a new intravenous anesthetic. Anesthesiology 1989;71:260-77.
2. Stephan H, Sonntag H, Schenk HD, et al. Effects of propofol on cardiovascular dynamics, myocardial blood flow myocardial metabolism in patients with coronary artery disease. Br J Anaesth 1986;58:969-75.
3. Monk CR, Coates DP, Prys-Roberts C, et al. Haemodynamic effects of a prolonged infusion of propofol as a supplement to nitrous oxide anaesthesia: studies in association with peripheral arterial surgery. Br J Anaesth 1987;59:954-60.
4. Larsen R, Rathgeber J, Bagdahn A, et al. Effects of propofol on cardiovascular dynamics and coronary blood flow in geriatric patients: a comparison with etomidate. Anaesthesia 1988; 43(Suppl.):25-31.
5. Merin RG. Propofol causes cardiovascular depression. I. Anesthesiology 1990;72:393-4.
6. Van Aken H. Propofol causes cardiovascular depression. II. Anesthesiology 1990;72:394-5.
7. Mayer N, Legat K, Weinstabl C, Zimpfer M. Effects of propofol on the function of normal, collateral-dependent, and ischemic myocardium. Anesth Analg 1993;76:33-9.
8. Bell J, Sartain J, Wilkinson GAL, Sherry KM. Propofol and fentanyl anaesthesia for patients with low cardiac output states undergoing cardiac surgery: comparison with high-dose fentanyl anaesthesia. Br J Anaesth 1994;73:162-6.
9. 2O in humans. Anesthesiology 1988;68:157-63.
10. Skoyles JR, Sherry KM. Pharmacology, mechanisms of action and uses of selective phosphodiesterase inhibitors. Br J Anaesth 1992;68:293-302.
11. Molter G, Larsen R, Peters U, et al. Haemodynamic changes produced by inhalation anaesthetics in the presence of phosphodiesterase inhibition. Br J Anaesth 1993;70:428-33.
12. Stolley PD, Strom BL. Sample size calculations for clinical pharmacology studies. Clin Pharmacol Ther 1986;39:489-90.
13. Coates DP, Monk CR, Prys-Roberts C, Turtle M. Hemodynamic effects of infusions of the emulsion formulation of propofol during nitrous oxide anesthesia in humans. Anesth Analg 1987; 66:64-70.
14. Lepage J-YM, Pinaud ML, Helias JH, et al. Left ventricular function during propofol and fentanyl anesthesia in patients with coronary artery disease: assessment with a radionuclide approach. Anesth Analg 1988;67:949-55.
15. Vermeyen KM, Erpels FA, Janssen LA, et al. Propofol-fentanyl anaesthesia for coronary bypass surgery in patients with good left ventricular function. Br J Anaesth 1987;59:1115-20.
16. Grounds RM, Twigley AJ, Carli F, et al. The haemodynamic effects of intravenous induction: comparison of the effects of thiopentone and propofol. Anaesthesia 1985;40:735-40.
17. Pagel PS, Warltier DC. Negative inotropic effects of propofol as evaluated by the regional preload recruitable stroke work relationship in chronically instrumented dogs. Anesthesiology 1993; 78:100-8.
18. Brüssel T, Theissen JL, Vigfusson G, et al. Hemodynamic and cardio-dynamic effects of propofol and etomidate: negative inotropic properties of propofol. Anesth Analg 1989;69:35-40.
19. Vernon MW, Heel RC, Brogden RN. Enoximone: a review of its pharmacological properties and therapeutic potential. Drugs 1991;42:997-1017.
20. Alousi AA, Farah AE, Lesher GY, Opalka CJ. Cardiotonic activity of amrinone: win 40680 (5-Amino-3,4-bipyridin-6(1H)-one). Circ Res 1979;45:666-77.
21. Komai H, Rusy BF. Inotropic effect of amrinone in rabbit papillary muscle: reversal of myocardial depression effect of halothane. Can J Physiol Pharmacol 1984;62:1382-6.
22. Crawford MH, Richards KL, Sodums MT, Kennedy GT. Positive inotropic and vasodilator effects of MDL 17,043 in patients with reduced left ventricular performance. Am J of Cardiol 1984;53: 1051-3.
23. Uretsky BF, Generalovich T, Reddy PS, et al. The acute hemodynamic effects of a new agent, MDL 17,043, in the treatment of congestive heart failure. Circulation 1983;67:823-8.
24. Cullen PM, Turtle M, Prys-Roberts C, et al. Effects of propofol anesthesia on baroreflex activity in humans. Anesth Analg 1987; 66:1115-20.
25. Puttick RM, Terrar DA. Effects of propofol and enflurane on action potentials, membrane currents and contraction of guinea-pig isolated ventricular myocytes. Br J Pharmacol 1992;107: 559-65.
26. Miles WM, Heger JJ, Minardo JD, et al. The electrophysiological effects of enoximone in patients with preexisting ventricular tachyarrhythmias. Am Heart J 1990;117:112-21.
27. Claeys MA, Gepts E, Camu F. Haemodynamic changes during aneasthesia induced and maintained with propofol. Br J Anaesth 1988;60:3-9.