메뉴 건너뛰기




Volumn 105, Issue 10, 1997, Pages 765-772

Association between p53 overexpression, cell proliferation, tumor necrosis and extent of apoptosis in operated pancreatic adenocarcinoma

Author keywords

Apoptosis; Carcinoma; Cell proliferation; Necrosis; p53; Pancreas

Indexed keywords

PROTEIN P53;

EID: 0030779033     PISSN: 09034641     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1699-0463.1997.tb05082.x     Document Type: Article
Times cited : (9)

References (35)
  • 1
    • 0028850813 scopus 로고
    • Clonal expansion and attenuated apoptosis in Wilm's tumors are associated with p53 gene mutations
    • Bardeesy, N., Beckwith, J. B. & Pelletier, J.: Clonal expansion and attenuated apoptosis in Wilm's tumors are associated with p53 gene mutations. Cancer Res. 55: 215-219, 1995.
    • (1995) Cancer Res. , vol.55 , pp. 215-219
    • Bardeesy, N.1    Beckwith, J.B.2    Pelletier, J.3
  • 2
    • 0030024253 scopus 로고    scopus 로고
    • Apoptosis and immunohistochemical bcl-2 expression in colorectal adenomas and carcinomas. Aspects of carcinogenesis and prognostic significance
    • Baretton, G. B., Diebold, J., Christoforis, G. et al.: Apoptosis and immunohistochemical bcl-2 expression in colorectal adenomas and carcinomas. Aspects of carcinogenesis and prognostic significance. Cancer 77: 255-264, 1996.
    • (1996) Cancer , vol.77 , pp. 255-264
    • Baretton, G.B.1    Diebold, J.2    Christoforis, G.3
  • 3
    • 0028305095 scopus 로고
    • Overexpression of p53 protein in adenocarcinoma of the pancreas
    • DiGiuseppe, J. A., Hruban, R. H., Goodman, S. N. et al.: Overexpression of p53 protein in adenocarcinoma of the pancreas. Am. J. Clin. Pathol. 101: 684-688, 1994.
    • (1994) Am. J. Clin. Pathol. , vol.101 , pp. 684-688
    • Digiuseppe, J.A.1    Hruban, R.H.2    Goodman, S.N.3
  • 4
    • 1842406622 scopus 로고    scopus 로고
    • Apoptosis is inversely related to tumour necrosis and p53 immunoreactivity in operated small cell lung carcinomas
    • Eerola, A.-K., Törmänen, U., Soini, Y. et al.: Apoptosis is inversely related to tumour necrosis and p53 immunoreactivity in operated small cell lung carcinomas. J. Pathol. 181: 172-177, 1997.
    • (1997) J. Pathol. , vol.181 , pp. 172-177
    • Eerola, A.-K.1    Törmänen, U.2    Soini, Y.3
  • 5
    • 0003327168 scopus 로고
    • Histological Typing of Tumours of the Liver, Biliary Tract and Pancreas
    • World Health Organization, Geneva
    • Gibson, J. B. & Sobin, L. H.: Histological Typing of Tumours of the Liver, Biliary Tract and Pancreas. International Histological Classification of Tumours No. 20. World Health Organization, Geneva 1978.
    • (1978) International Histological Classification of Tumours No. 20. , vol.20
    • Gibson, J.B.1    Sobin, L.H.2
  • 6
    • 0028071555 scopus 로고
    • Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis
    • Greenblatt, M. S., Bennett, W. P., Hollstein, M. et al.: Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis. Cancer Res. 55: 4855-5878, 1994.
    • (1994) Cancer Res. , vol.55 , pp. 4855-5878
    • Greenblatt, M.S.1    Bennett, W.P.2    Hollstein, M.3
  • 7
    • 0025678485 scopus 로고
    • Proliferative cell nuclear antigen (PCNA) immunolocalization in paraffin sections: An index of cell proliferation with evidence of deregulated expression in some neoplasms
    • Hall, P. A., Levinson, D. A., Woods, A. L. et al.: Proliferative cell nuclear antigen (PCNA) immunolocalization in paraffin sections: an index of cell proliferation with evidence of deregulated expression in some neoplasms. J. Pathol. 162: 285-294, 1990.
    • (1990) J. Pathol. , vol.162 , pp. 285-294
    • Hall, P.A.1    Levinson, D.A.2    Woods, A.L.3
  • 8
    • 0028605481 scopus 로고
    • Bcl-2 in cancer, development and apoptosis
    • Hockenbery, D. M.: Bcl-2 in cancer, development and apoptosis. J. Cell Sci. 18: 51-55, 1994.
    • (1994) J. Cell Sci. , vol.18 , pp. 51-55
    • Hockenbery, D.M.1
  • 10
    • 0028329172 scopus 로고
    • Apoptosis. Its significance in cancer and cancer therapy
    • Kerr, J. F. R., Winterford, C. M. & Harmon, B. V.: Apoptosis. Its significance in cancer and cancer therapy. Cancer 73: 2013-2026, 1994.
    • (1994) Cancer , vol.73 , pp. 2013-2026
    • Kerr, J.F.R.1    Winterford, C.M.2    Harmon, B.V.3
  • 11
    • 0021891243 scopus 로고
    • Histological and fine structural features of pancreatic ductal adenocarcinomas in relation to growth and prognosis: Studies in xenografted tumours and clinicohistopathological correlation in a series of 75 cases
    • Klöppel, G., Lingenthal, G., von Bulow, M. & Kern, H. F.: Histological and fine structural features of pancreatic ductal adenocarcinomas in relation to growth and prognosis: studies in xenografted tumours and clinicohistopathological correlation in a series of 75 cases. Histopathology 9: 841-856, 1985.
    • (1985) Histopathology , vol.9 , pp. 841-856
    • Klöppel, G.1    Lingenthal, G.2    Von Bulow, M.3    Kern, H.F.4
  • 12
    • 0027109075 scopus 로고
    • P53, guardian of the genome
    • Lane, D. P.: p53, guardian of the genome. Nature 358: 15-16, 1992.
    • (1992) Nature , vol.358 , pp. 15-16
    • Lane, D.P.1
  • 13
    • 0021379737 scopus 로고
    • Role of p53 protein in cell proliferation as studied by microinjection of monoclonal antibodies
    • Mercer, W. E., Avignolo, C. & Basegra, R.: Role of p53 protein in cell proliferation as studied by microinjection of monoclonal antibodies. Mol. Cell Biol. 4: 276-281, 1984.
    • (1984) Mol. Cell Biol. , vol.4 , pp. 276-281
    • Mercer, W.E.1    Avignolo, C.2    Basegra, R.3
  • 14
    • 0026065497 scopus 로고
    • Growth suppression induced by wild-type p53 is accompanied by selective growth regulation of proliferating-cell nuclear antigen expression
    • Mercer, W. E., Shields, M. T., Lin, D. et al.: Growth suppression induced by wild-type p53 is accompanied by selective growth regulation of proliferating-cell nuclear antigen expression. Proc. Natl. Acad. Sci. USA 88: 1958-1962, 1991.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 1958-1962
    • Mercer, W.E.1    Shields, M.T.2    Lin, D.3
  • 15
    • 0026149877 scopus 로고
    • The role of p53 in normal control of cell proliferation
    • Milner, J.: The role of p53 in normal control of cell proliferation. Curr. Opin. Cell Biol. 3: 282-286, 1991.
    • (1991) Curr. Opin. Cell Biol. , vol.3 , pp. 282-286
    • Milner, J.1
  • 16
    • 0028335717 scopus 로고
    • Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo
    • Miyashita, T., Krajewski, S., Krajewski, M. et al.: Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene 9: 1799-1805, 1994.
    • (1994) Oncogene , vol.9 , pp. 1799-1805
    • Miyashita, T.1    Krajewski, S.2    Krajewski, M.3
  • 17
    • 0028883179 scopus 로고
    • Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
    • Miyashita, T. & Reed, J. C.: Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80: 293-299, 1995.
    • (1995) Cell , vol.80 , pp. 293-299
    • Miyashita, T.1    Reed, J.C.2
  • 18
    • 0024387728 scopus 로고
    • Mutations in the p53 gene occur in diverse human tumour types
    • Nigro, J. M., Baker, S. J., Preisinger, A. C. et al.: Mutations in the p53 gene occur in diverse human tumour types. Nature 342: 705-708, 1989.
    • (1989) Nature , vol.342 , pp. 705-708
    • Nigro, J.M.1    Baker, S.J.2    Preisinger, A.C.3
  • 19
    • 0030057349 scopus 로고    scopus 로고
    • Apoptosis occurs independently of bcl-2 and p53 over-expression in non-small cell lung carcinoma
    • O'Neill, A. J., Staunton, M. J. & Gaffney, E. F.: Apoptosis occurs independently of bcl-2 and p53 over-expression in non-small cell lung carcinoma. Histopathology 29: 45-50, 1996.
    • (1996) Histopathology , vol.29 , pp. 45-50
    • O'Neill, A.J.1    Staunton, M.J.2    Gaffney, E.F.3
  • 20
    • 0027079951 scopus 로고
    • Immunodetection of proliferating cell nuclear antigen assesses the growth fraction and predicts malignancy in endocrine tumors of the pancreas
    • Pelosi, G., Zamboni, G., Doglioni, C. et al.: Immunodetection of proliferating cell nuclear antigen assesses the growth fraction and predicts malignancy in endocrine tumors of the pancreas. Am. J. Surg. Pathol. 16: 1215-1225, 1992.
    • (1992) Am. J. Surg. Pathol. , vol.16 , pp. 1215-1225
    • Pelosi, G.1    Zamboni, G.2    Doglioni, C.3
  • 21
    • 0026737950 scopus 로고
    • Accumulation of p53 protein correlates with a poor prognosis in human lung cancer
    • Quinlan, D. C., Davidson, A. G., Summers, C. L. et al.: Accumulation of p53 protein correlates with a poor prognosis in human lung cancer. Cancer Res. 52: 4828-4831, 1992.
    • (1992) Cancer Res. , vol.52 , pp. 4828-4831
    • Quinlan, D.C.1    Davidson, A.G.2    Summers, C.L.3
  • 22
    • 0028308492 scopus 로고
    • P53 mutations in pancreatic carcinoma and evidence of common involvement of homopolymer tracts in DNA microdeletions
    • Redston, M. S., Caldas, C., Seymour, A. B. et al.: p53 mutations in pancreatic carcinoma and evidence of common involvement of homopolymer tracts in DNA microdeletions. Cancer Res. 54: 3025-3033, 1994.
    • (1994) Cancer Res. , vol.54 , pp. 3025-3033
    • Redston, M.S.1    Caldas, C.2    Seymour, A.B.3
  • 23
    • 0028040019 scopus 로고
    • Bcl-2 and the regulation of pro- Grammed cell death
    • Reed, J. C.: Bcl-2 and the regulation of pro- grammed cell death. J. Cell Biol. 124: 1-6, 1994.
    • (1994) J. Cell Biol. , vol.124 , pp. 1-6
    • Reed, J.C.1
  • 24
    • 0027743438 scopus 로고
    • Pancreatic adenocarcinoma frequently show p53 gene mutations
    • Scarpa, A., Capelli, P., Mukai, K. et al.: Pancreatic adenocarcinoma frequently show p53 gene mutations. Am. J. Pathol. 142: 1534-1543, 1993.
    • (1993) Am. J. Pathol. , vol.142 , pp. 1534-1543
    • Scarpa, A.1    Capelli, P.2    Mukai, K.3
  • 25
    • 0026546407 scopus 로고
    • Proliferating cell nuclear antigen is required for DNA excision repair
    • Shivji, M. K., Kenny, M. K. & Wood, R. D.: Proliferating cell nuclear antigen is required for DNA excision repair. Cell 69: 367-374, 1992.
    • (1992) Cell , vol.69 , pp. 367-374
    • Shivji, M.K.1    Kenny, M.K.2    Wood, R.D.3
  • 26
    • 0027515257 scopus 로고
    • P53 immunohistochemistry in transitional cell carcinoma and dysplasia of the urinary bladder correlates with disease progression
    • Soini, Y., Pääkkö, P., Nuorva, K. et al.: p53 immunohistochemistry in transitional cell carcinoma and dysplasia of the urinary bladder correlates with disease progression. Br. J. Cancer 68: 1029-1035, 1993.
    • (1993) Br. J. Cancer , vol.68 , pp. 1029-1035
    • Soini, Y.1    Pääkkö, P.2    Nuorva, K.3
  • 27
    • 0029987762 scopus 로고    scopus 로고
    • Hepatocellular carcinomas with a high proliferation index and a low degree of apoptosis and necrosis are associated with a shortened survival
    • Soini, Y., Virkajärvi, N., Lehto, V.-P. et al.: Hepatocellular carcinomas with a high proliferation index and a low degree of apoptosis and necrosis are associated with a shortened survival. Br. J. Cancer 73: 1025-1030, 1996.
    • (1996) Br. J. Cancer , vol.73 , pp. 1025-1030
    • Soini, Y.1    Virkajärvi, N.2    Lehto, V.-P.3
  • 28
    • 0029854194 scopus 로고    scopus 로고
    • Extent of apoptosis in relation to p53 and bcl-2 expression in germ cell tumors
    • Soini, Y. & Pääkkö, P.: Extent of apoptosis in relation to p53 and bcl-2 expression in germ cell tumors. Hum. Pathol. 27: 1221-1226, 1996.
    • (1996) Hum. Pathol. , vol.27 , pp. 1221-1226
    • Soini, Y.1    Pääkkö, P.2
  • 29
    • 0026709391 scopus 로고
    • Comparative analysis of p53 protein immunoreactivity in prostatic, lung and breast carcinomas
    • Soini, Y., Pääkkö, P., Nuorva, K. et al.: Comparative analysis of p53 protein immunoreactivity in prostatic, lung and breast carcinomas. Virchows Arch. A 421: 223-228, 1992.
    • (1992) Virchows Arch. A , vol.421 , pp. 223-228
    • Soini, Y.1    Pääkkö, P.2    Nuorva, K.3
  • 30
  • 31
    • 0026724877 scopus 로고
    • Accumulation of p53 tumor suppressor gene proteIn: An independent marker of prognosis in breast cancers
    • Thor, A., Moore, II, D. H., Edgerton, S. M. et al.: Accumulation of p53 tumor suppressor gene proteIn: An independent marker of prognosis in breast cancers. J. Natl. Cancer Inst. 84: 845-855, 1992.
    • (1992) J. Natl. Cancer Inst. , vol.84 , pp. 845-855
    • Thor, A.1    Moore II, D.H.2    Edgerton, S.M.3
  • 32
    • 0028787781 scopus 로고
    • Enhanced apoptosis predicts shortened survival in non-small cell lung carcinoma
    • Törmänen, U., Eerola, A.-K., Rainio, P. et al.: Enhanced apoptosis predicts shortened survival in non-small cell lung carcinoma. Cancer Res. 55: 5595-5602, 1995.
    • (1995) Cancer Res. , vol.55 , pp. 5595-5602
    • Törmänen, U.1    Eerola, A.-K.2    Rainio, P.3
  • 33
    • 0030048977 scopus 로고    scopus 로고
    • P53, Ki-ras and DNA ploidy in human pancreatic ductal adenocarcinomas
    • Weyrer, K., Feichtinger, H., Haun, M. et al.: p53, Ki-ras and DNA ploidy in human pancreatic ductal adenocarcinomas. Lab. Invest. 74: 279-289, 1996.
    • (1996) Lab. Invest. , vol.74 , pp. 279-289
    • Weyrer, K.1    Feichtinger, H.2    Haun, M.3
  • 34
    • 0024633224 scopus 로고
    • Carcinoma of the pancreas: A clinicopathologic study of 96 cases with immunohistochemical observations
    • Yamaguchi, K. & Enjoji, M.: Carcinoma of the pancreas: a clinicopathologic study of 96 cases with immunohistochemical observations. Jpn. J. Clin. Oncol. 19: 14-22, 1989.
    • (1989) Jpn. J. Clin. Oncol. , vol.19 , pp. 14-22
    • Yamaguchi, K.1    Enjoji, M.2
  • 35
    • 0025784539 scopus 로고
    • Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6
    • Yonish-Rouach, E., Resnitzky, D., Lotem, J. et al.: Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6. Nature 352: 345-347, 1991.
    • (1991) Nature , vol.352 , pp. 345-347
    • Yonish-Rouach, E.1    Resnitzky, D.2    Lotem, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.