Artesunate suppositories: An effective treatment for severe falciparum malaria in rural areas

Annals of Tropical Medicine and Parasitology

Volumn 91, Issue 7, 1997, Pages 891-896

  Wilairatana, P ^a   Viriyavejakul, P ^a   Looareesuwan, S ^a   Chongsuphajaisiddhi, T ^a  

^a MAHIDOL UNIVERSITY   (Thailand)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; ARTEMISININ; ARTESUNATE; DIHYDROARTEMISININ; DRUG METABOLITE; MEFLOQUINE;

AREA UNDER THE CURVE; ARTICLE; CLINICAL TRIAL; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG FORMULATION; DRUG HALF LIFE; DRUG METABOLISM; DRUG TOLERANCE; HUMAN; MALARIA FALCIPARUM; ORAL DRUG ADMINISTRATION; PHARMACODYNAMICS; RECTAL DRUG ADMINISTRATION; RECURRENT DISEASE; RURAL AREA; SUPPOSITORY;

ACUTE DISEASE; ANTIMALARIALS; ARTEMISININS; DRUG THERAPY, COMBINATION; HUMANS; MALARIA, FALCIPARUM; MEFLOQUINE; PARASITEMIA; RURAL HEALTH; SESQUITERPENES; SUPPOSITORIES;

EID: 0030778461     PISSN: 00034983     EISSN: None     Source Type: Journal    
DOI: 10.1080/00034989760662     Document Type: Article

References (27)

1. ARNOLD, K. (1994). Early treatment of malaria in the community using artemisinin-hope or hazard? Transactions of the Royal Society of Tropical Medicine and Hygiene, 88 (Suppl. 1), S47-S49.
2. ARNOLD, K., HIEN, T. T., CHINH, N. T., PHU, N. H. & MAI, P. P. (1990). A randomised comparative study of artemisinin (qinghaosu) suppositories and oral quinine in acute falciparum malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene, 84, 499-502.
3. BARRADELL, L. B. & FITTON, A. (1995). Artesunate. A review of its pharmacology and therapeutic efficacy in the treatment of malaria. Drugs, 50, 714-741.
4. BENAKIS, A., PARIS, M., LOUTAN, L., PLESSAS, C. T. & PLESSAS, S. T. (1996). Pharmacokinetic study of a new pharmaceutical form of artesunate (Plasmotrim®-200 Rectocaps) administered in healthy volunteers by rectal route. Japanese Journal of Tropical Medicine and Hygiene, 24 (Suppl. 1), 39-45.
5. BHATT, K. M., BHATT, S. M., OMONGE, E., OTEKO, L. & ANDRIAL, M. (1996). Efficacy and tolerability of a sequential artesunate suppository-mefloquine treatment of severe falciparum malaria. Japanese Journal of Tropical Medicine and Hygiene, 24 (Suppl. 1), 59-63.
6. BUNNAG, D., KARBWANG, J. & HARINASUTA, T. (1992a). Artemether in the treatment of multidrug resistant falciparum malaria. Southeast Asian Journal of Tropical Medicine and Public Health, 23, 762-767.
7. BUNNAG, D., VIRAVAN, C., LOOAREESUWAN, S., KARBWANG, J. & HARINASUTA, T. (1992b). Clinical trial of artesunate and artemether in multidrug-resistant falciparum malaria in Thailand: a preliminary report. Southeast Asian Journal of Tropical Medicine and Public Health, 22, 380-385.
8. FIELD, J. W. & NIVEN, J. C. (1937). A note on a prognosis in relation to parasite counts in acute subtertian malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene, 30, 569-574.
9. GOMEZ LANDIRES, E. A. (1996). Efficacy of artesunate suppository followed by oral mefloquine in the treatment of severe falciparum malaria in endemic areas were resistance to chloroquine exits in Ecuador. Japanese Journal of Tropical Medicine and Hygiene, 24 (Suppl. 1), 17-24.
10. HERMANN, T. W. (1995). Recent research on bioavailability of drugs from suppositories. International Journal of Pharmacology, 123, 1-11.
11. HIEN, T. T., TAM, D. T. H., CUC, N. T. K. & ARNOLD, K. (1991). Comparative effectiveness of artemisinin suppositories and oral quinine in children with acute falciparum malaria. Transactions of the Royal Society of Tropical Medicine and Hygiene, 85, 210-211.
12. HOFFMAN, S. L. (1992). Diagnosis, treatment, and prevention of malaria. Medical Clinics of North America, 76, 1327-1355.
13. LI, G. Q., GUO, X. B., JIAN, H. X., FU, L. C., SHEN, L. C., LI, R. S., DAI, B. Q. & LI, A. L. (1985). Observation on the efficacy of qinghaosu suppository in 100 cases of falciparum malaria. Journal of Traditional Chinese Medicine, 5, 159-161.
14. LI, G. Q., GUO, X. B., FU, L. C., JIAN, H. X. & WANG, X. H. (1994). Clinical trials of artemisinin and its derivatives in the treatment of malaria in China. Transactions of the Royal Society of Tropical Medicine and Hygiene, 88 (Suppl. 1), S5-S6.
15. LOOAREESUWAN, S. & WILAIRATANA, P. (1997). Malaria. In 1997 Conn's Current Therapy, ed Rakel, R. E. pp. 104-115. Philadelphia: W.B. Saunders.
16. LOOAREESUWAN, S., KYLE, D. E., VIRAVAN, C., VANIJANONTA, S., WILAIRATANA, P., CHAROENLARP, P., CANFIELD, C. J. & WEBSTER, H. K. (1992a). Treatment of patients with recrudescence falciparum malaria with a sequential combination of artesunate and mefloquine. American Journal of Tropical Medicine and Hygiene, 47, 794-799.
17. LOOAREESUWAN, S., VIRAVAN, C., VANIJANONTA, S., WILAIRATANA, P., SUNTHARASAMAI, P., CHAROENLARP, P., ARNOLD, K., KYLE, D. E., CANFIELD, C. & WEBSTER, H. K. (1992b). A randomised trial of mefloquine, artesunate, and artesunate followed by mefloquine in acute uncomplicated falciparum malaria. Lancet, i, 821-824.
18. LOOAREESUWAN, S, VANIJANONTA, S., VIRAVAN, C., WILAIRATANA, P., CHAROENLARP, P. & ANDRIAL, M. (1994). Randomised trial of mefloquine alone and artesunate followed by mefloquine for the treatment of acute uncomplicated falciparum malaria. Annals of Tropical Medicine and Parasitology, 88, 131-136.
19. LOOAREESUWAN, S., WILAIRATANA, P., VANIJANONTA, S., VIRAVAN, C. & ANDRIAL, M. (1995). Efficacy and tolerability of a sequential, artesunate suppository plus mefloquine, treatment of severe falciparum malaria. Annals of Tropical Medicine and Parasitology, 89, 469-475.
20. LOOAREESUWAN, S., WILAIRATANA, P. & ANDRIAL, M. (1996). Artesunate suppository for treatment of severe falciparum malaria in Thailand. Japanese Journal of Tropical Medicine and Hygiene, 24 (Suppl. 1), 13-15.
21. MESHNICK, S. R., TAYLOR, T. E. & KAMCHONWONGPAISAN, S. (1996). Artemisinin and the antimalarial endoperoxides: from herbal remedy to targeted chemotherapy. Microbiological Reviews, 60, 301-315
22. MOLYNEUX, M. E., TAYLOR, T. E., WIRIMA, J. J. & BORGSTEIN, A. (1989). Clinical features and prognostic indicators in paediatric cerebral malaria: a study of 131 comatose Malawian children. Quarterly Journal of Medicine, 265, 441-459.
23. TER KUILE, F., WHITE, N. J., HOLLOWAY, P., PASVOL, G. & KRISNA, S. (1993). Plasmodium falciparum: in vitro studies of the pharmacodynamic properties of drugs used for the treatment of the severe malaria. Experimental Parasitology, 76, 85-95.
24. THWE, Y., THAN, M., PHAY, S., OO, A. Z. & SOE, A. Y. (1996). Artesunate suppository-mefloquine tablets (Plasmotrim®, Rectocaps®, Mefloquine®, Lactab®) in the treatment of severe falciparum malaria. Japanese Journal of Tropical Medicine and Hygiene, 24 (Suppl. 1), 25-32.
25. WHITE, N. J. (1994). Artemisinin: current status. Transactions of the Royal Society of Tropical Medicine and Hygiene, 88 (Suppl. 1), S3-S4.
26. WILAIRATANA, P. & LOOAREESUWAN, S. (1995). APACHE II scoring for predicting outcome in cerebral malaria. Journal of Tropical Medicine and Hygiene, 98, 256-260.
27. WORLD HEALTH ORGANIZATION (1993). Global malaria control. Bulletin of the World Health Organization, 71, 281-284.