Localization and effects of calcitonin gene-related peptide in the testicular vasculature of the rat

Journal of Andrology

Volumn 18, Issue 4, 1997, Pages 385-392

  Lissbrant, Erik ^a   Collin, Ola ^a   Bergh, Anders ^a  

^a UMEÅ UNIVERSITY   (Sweden)

Author keywords

Blood flow; CGRP; Testis; Vasomotion

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; CALCITONIN GENE RELATED PEPTIDE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD FLOW; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; INTRATESTICULAR DRUG ADMINISTRATION; LASER DOPPLER FLOWMETRY; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; REGULATORY MECHANISM; TESTIS; VASODILATATION;

ANIMALS; CALCITONIN GENE-RELATED PEPTIDE; IMMUNOHISTOCHEMISTRY; MALE; RATS; RATS, SPRAGUE-DAWLEY; REGIONAL BLOOD FLOW; TESTIS;

EID: 0030777933     PISSN: 01963635     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Bergh A, Damber J-E. Vascular controls in testicular physiology. In: Kretser DM, ed. Molecular Biology of the Male Reproductive System. New York: Academic Press; 1993:439-468.
2. Brain SD, Cambridge H. Calcitonin gene-related peptide: vasoactive effects and potential therapeutic role. Gen Pharm 1996;27:607-611.
3. Brain SD, Williams TJ, Tippins JR, Morris HR, MacIntyre SD. Calcitonin gene-related peptide is a potent vasodilator. Nature 1985;313:54-56.
4. Calka J, McDonald JK, Ojeda SR. The innervation of the immature rat ovary by calcitonin gene-related peptide. Biol Reprod 1988;39: 1215-1223.
5. Collin O, Damber J-E, Bergh A. 5-Hydroxytryptamine - a local regulator of testicular blood flow and vasomotion in rats. J Reprod Fertil 1996a;106:17-22.
6. Collin O, Damber J-E, Bergh A. Effects of endothelin-1 on the rat testicular vasculature. J Androl 1996b;17:360-366.
7. 8-37, a calcitonin gene-related peptide antagonist revealing calcitonin gene-related peptide receptor heterogeneity in brain and periphery. J Pharmacol Exp Ther 1990;254:123-128.
8. Fantini F, Magnoni C, Pincelli C, Giannetti A. Neurogenic inflammation and the skin: neuronal modulation of cutaneous inflammatory reactions. Eur J Dermatol 1995;5:349-357.
9. Fleet IR, Laurie MS, Noordhuizen-Stassen EN, Setchell BP. The flow of blood from the artery to vein in the spermatic cord of the ram, with some observations on reactive hyperaemia in the testis and the effects of adenosine and noradrenaline. J Physiol 1982;332:44P-45P.
10. Free MJ. Blood supply to the testis and its role in local exchange and transport of hormones. In: Johnson AD, Gomes WR. eds. The Testis. Vol IV. New York: Academic Press; 1977:39-90.
11. Hong KW, Pyo KM, Lee WS, Yu SS, Rhim BY. Pharmacological evidence that calcitonin gene-related peptide is implicated in cerebral autoregulation. Am J Physiol (Heart Circ Physiol) 1994;266(35):H11-H16.
12. Kumazawa T, Mizumura K. Mechanical and thermal responses of polymodal receptors recorded from the superior spermatic nerve of dogs. J Physiol 1980a;299:233-245.
13. Kumazawa T, Mizumura K. Chemical responses of polymodal receptors of the scrotal contents in dogs. J Physiol 1980b;299:219-231.
14. Lamano Carvalho TL, Hodson NP, Blank MA, Watson PF, Mulderry PK, Bishop AE, Gu J, Bloom SR, Polak JM. Occurrence, distribution and origin of peptide-containing nerves of guinea-pig and rat male genitalia and the effects of denervation on sperm characteristics. J Anat 1986;149:121-141.
15. Lissbrant E. Löfmark U, Collin O, Bergh A. Is nitric oxide involved in the regulation of the rat testicular vasculature? Biol Reprod 1997;57:1221-1227.
16. Morita-Tsuzuki Y, Bouskela E, Hardebo JE. Vasomotion in the rat cerebral microcirculation recorded by laser-Doppler flowmetry. Acta Physiol Scand 1992;146:431-439.
17. Nolte T, Harleman JH, Jahn W. Histopathology of chemically induced testicular atrophy in rats. Exp Toxic Pathol 1995;47:267-286.
18. Okimura Y, Chihara K, Abe H, Kita T, Kashio Y, Sato M, Fujita T. Calcitonin gene-related peptide-like immunoreactivity in the central nervous system and peripheral organs of rats. Regulatory Peptides 1987;17:327-337.
19. Properzi G, Cordeschi G, Francavilla S. Postnatal development and distribution of peptide-containing nerves in the genital system of the male rat. Histochemistry 1992;97:61-68.
20. Russell LD, Saxena NK, Weber JE. Intratesticular injection as a method to assess the potential toxicity of various agents and to study mechanisms of normal spermatogenesis. Gamete Res 1987;17:43-56.
21. Setchell BP, Bergh A, Widmark A, Damber J-E. Effect of temperature of the testis on vasomotion and blood flow, Int J Androl 1995;18:120-126.
22. Setchell BP, Maddocks S, Brooks DE. Anatomy, vasculature, innervation, and fluids of the male reproductive tract. In: Knobil E, Neill JD. eds. The Physiology of Reproduction. Second Ed. New York: Raven Press Ltd; 1994:1063-1175.
23. Silverman JD, Kruger L. Lectin and neuropeptide labeling of separate populations of dorsal root ganglion neurons and associated "nociceptor" thin axons in rat testis and cornea whole-mount preparations. Somatosens Res 1988;5(3):259-267.
24. Sweeney TE, Rozum JS, Desjardins C, Gore RW. Microvascular pressure distribution in the hamster testis. Am J Physiol 1991;260:H1581-H1589.
25. Tainio H. Peptidergic innervation of the human testis and epididymis. Acta Histochem 1994;96:415-420.
26. Tamura R, Mizumura K, Kumazawa T. Coexistence of calcitonin gene-related peptide- and substance P-like immunoreactivity in retrogradely labeled superior spermatic neurons in the dog. Neurosci Res 1996;25: 293-299.
27. Turner TT, Caplis L, Miller DW. Testicular microvascular blood flow: alteration after Leydig cell eradication and ischemia but not experimental varicocele. J Androl 1996;17:239-248.
28. Tyml K, Roman RJ, Lombard JH. Blood flow in skeletal muscle. In: Shepherd AP. Öberg PÄ, eds. Laser-Doppler Blood Flowmetry. Dordrecht: Kluwer Academic Publishers; 1990:215-226.
29. Zaidi M, Bevis PJR, Abeyasekera G, Girgis SI, Wimalawansa SJ, Morris HR, MacIntyre I. The origin of circulating calcitonin gene-related peptide in the rat. J Endocrinol 1986;110:185-190.