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1
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0028906338
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Autism as a strongly genetic disorder: Evidence from a British twin study
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Bailey A, LeCouteur A, Gottesman I, Bolton P, Simonoff E, Yuzda E, Rutter M: Autism as a strongly genetic disorder: evidence from a British twin study. Psychol Med 1995, 25:63-77. Extends the findings of the first systematic twin study by Folstein and Rutter [2] and documents the importance of hereditary factors in autism and the broader autism phenotype.
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Bailey, A.1
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Infantile autism: A genetic study of 21 twin pairs
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3
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0028359950
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A case-control family history study of autism
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Bolton P, Macdonald H, Pickles A, Rios P, Goode S, Crowson M, Bailey A, Rutter M: A case-control family history study of autism. J Child Psychol Psychiatry 1994, 35:877-900.
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J Child Psychol Psychiatry
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Bolton, P.1
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Bailey, A.7
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4
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0031035019
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The broader autism phenotype: Evidence from a family study of multiple-incidence autism families
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Piven J, Palmer P, Jacobi D, Childress D, Arndt S: The broader autism phenotype: evidence from a family study of multiple-incidence autism families. Am J Psychiatry 1997, 154:185-190.
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Am J Psychiatry
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Piven, J.1
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5
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Personality and language characteristics in parents from multiple-incidence autism families
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Piven J, Palmer P, Landa R: Personality and language characteristics in parents from multiple-incidence autism families. Am J Med Genet 1997, 74:398-411. Refines definitions of the broader autism phenotype in a sample of families ascertained through two autistic probands and directly assessed.
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Am J Med Genet
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Piven, J.1
Palmer, P.2
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6
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0030855007
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Parents of children with Asperger syndrome: What is the cognitive phenotype?
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Baron-Cohen S, Hammer J: Parents of children with Asperger syndrome: what is the cognitive phenotype? J Cogn Neurosci 1997, 9:548-554. Extends previous reports defining a broader autism phenotype by showing that parents of children with Asperger Syndrome appear to have difficulty interpreting the mental states of others. This deficit in parents is consistent with the finding of deficits in 'theory of mind' in autistic individuals.
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J Cogn Neurosci
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Baron-Cohen, S.1
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7
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Cognitive deficits in parents from multiple-incidence autism families
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Piven J, Palmer P: Cognitive deficits in parents from multiple-incidence autism families. J Child Psychol Psychiatry 1997, in press. Direct testing of parents ascertained through two autistic probands shows evidence of cognitive deficits, suggesting that particular cognitive characteristics may also be components of a broader autism phenotype.
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J Child Psychol Psychiatry
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Piven, J.1
Palmer, P.2
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8
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0031029742
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Executive function in parents of children with autism
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Hughes C, LeBoyer M, Bouvard M: Executive function in parents of children with autism. Psychol Med 1997, 27:209-220.
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Hughes, C.1
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9
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Autism, affective disorders, and social phobia
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Smalley S, McCracken J, Tanguay P: Autism, affective disorders, and social phobia. Am J Med Genet 1995, 60:19-26.
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Smalley, S.1
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10
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Obstetric complications in autism: Consequences or causes of the condition?
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Bolton P, Murphy M, MacDonald H, Whitlock B, Pickles A, Rutter M: Obstetric complications in autism: consequences or causes of the condition? J Am Acad Child Adolesc Psychiatry 1997, 36:272-281. Presents evidence to suggest that the association of perinatal factors and autism, found in some studies, may be a consequence of the genetic liability for autism rather than an independent risk factor for the disorder.
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J am Acad Child Adolesc Psychiatry
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Bolton, P.1
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11
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0029134874
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Latent-class analysis of recurrence risks for complex phenotypes with selection and measurement error: A twin and family history study of autism
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Pickles A, Bolton P, Macdonald H, Bailey A, LeCouteur A, Sim C-H, Rutter M: Latent-class analysis of recurrence risks for complex phenotypes with selection and measurement error: a twin and family history study of autism Am J Hum Genet 1995, 57:717-726. This is the first paper to undertake a genetic analysis of autism, including affected individuals with the broader autism phenotype. The results suggest that autism is an oligogenic disorder.
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Am J Hum Genet
, vol.57
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Pickles, A.1
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Rutter, M.7
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12
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0031027824
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Susceptibility loci for distinct components of developmental dyslexia on chromosomes 6 and 15
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Grigorenko EL, Wood FB, Meyer MS, Hart LA, Speed WC, Shuster A, Pauls DL: Susceptibility loci for distinct components of developmental dyslexia on chromosomes 6 and 15. Am J Hum Genet 1997, 60:13-16.
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Am J Hum Genet
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Grigorenko, E.L.1
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Pauls, D.L.7
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13
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Autism and the X chromosome: Multipoint sib-pair analysis
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Hallmayer J, Hebert JM, Spiker D, Lotspeich L, McMahon WM, Petersen P, Nicholas P, Pingree C, Lin AA, Cavalli-Sforza LL et al.: Autism and the X chromosome: multipoint sib-pair analysis. Arch Gen Psychiatry 1996, 53:985-989.
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Hallmayer, J.1
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14
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0029116939
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Autism and genetics: Clinical approach and association study with two markers of HRAS gene
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Herault J, Petit E, Martineau J, Perrot A, Lenoir P, Cherpi C, Barthelemy C, Sauvage D, Mallet J, Muh JP, Lelord G: Autism and genetics: clinical approach and association study with two markers of HRAS gene. Am J Med Genet 1995, 60:276-281.
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Herault, J.1
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Barthelemy, C.7
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Muh, J.P.10
Lelord, G.11
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15
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0029120604
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Increased frequency of the extended or ancestral haplotype B44-SC30-DR4 in autism
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Daniels WW, Warren RP, Odell JD, Maciulis A, Burger RA, Warren WL, Torres AR: Increased frequency of the extended or ancestral haplotype B44-SC30-DR4 in autism. Biol Psychiatry 1995, 32:120-123.
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Daniels, W.W.1
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Warren, W.L.6
Torres, A.R.7
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16
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0030200135
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Strong association of the third hypervariable region of HLA-DR1 with autism
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Warren RP, Odell JD, Warren L, Burger RA, Maciulis A, Daniels WW, Torres AR: Strong association of the third hypervariable region of HLA-DR1 with autism. J Neuroimmunol 1996, 67:97-102.
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Warren, R.P.1
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Daniels, W.W.6
Torres, A.R.7
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17
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0029169674
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Association study with two markers of a human homeogene in infantile autism
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Petit E, Hérault J, Martineau J, Perrot A, Barthélémy C, Hameury L, Sauvage D, Lelord G, Müh JP: Association study with two markers of a human homeogene in infantile autism. J Med Genet 1995, 32:269-274.
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Petit, E.1
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18
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Evidence of linkage between the serotonin transporter and autistic disorder
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Cook EH, Courchesne R, Lord C, Cox NJ, Yan S, Lincoln A, Haas R, Courchesne E, Leventhal BL: Evidence of linkage between the serotonin transporter and autistic disorder. Mol Psychiatry 1997, 2:247-250. Provides preliminary evidence of possible linkage and association between autism and the serotonin transporter gene.
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Mol Psychiatry
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Cook, E.H.1
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19
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Cook EH, Lindgren V, Leventhal BL, Courchesne R, Lincoln A, Shulman C, Lord C, Courchesne E: Autism or atypical autism in maternally but not paternally derived proximal 15q duplication. Am J Hum Genet 1997, 60:928-934. Adds to recent evidence that the chromosome 15q11-q13 region may be involved in some cases of autism by showing maternal (but not paternal) transmission of a duplication in that region to be associated with autism.
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(1997)
Am J Hum Genet
, vol.60
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Cook, E.H.1
Lindgren, V.2
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Lincoln, A.5
Shulman, C.6
Lord, C.7
Courchesne, E.8
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20
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0030477054
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Maternal origin of inv dup (15) chromosomes in infantile autism
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Martinsson T, Johannesson T, Vujic M, Sjostedt A, Steffenburg S, Gillberg C, Wahlstrom J: Maternal origin of inv dup (15) chromosomes in infantile autism. Eur Child Adolesc Psychiatry 1996, 5:185-192.
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Eur Child Adolesc Psychiatry
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Martinsson, T.1
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21
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0029996407
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Executive functions and developmental psychopathology
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Pennington BF, Ozonoff S: Executive functions and developmental psychopathology. J Child Psychol Psychiatry 1996, 37:51-87. Provides a comprehensive review of executive function in autism.
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(1996)
J Child Psychol Psychiatry
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Pennington, B.F.1
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22
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0029782544
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The neuropsychology of autism
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Happé F, Frith T: The neuropsychology of autism. Brain 1996, 119:1377-1400. Reviews the evidence for competing theories regarding the neuropsychological basis of autism.
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Brain
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Happé, F.1
Frith, T.2
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23
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0029872978
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Autism: Toward an integration of clinical, genetic, neuropsychological, and neurobiological perspectives
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Bailey A, Philips W, Rutter M: Autism: toward an integration of clinical, genetic, neuropsychological, and neurobiological perspectives. J Child Psychol Psychiatry 1996, 37:89-126. Provides the most comprehensive integration to date of current data from a variety of related perspectives on the pathogenesis of autism.
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(1996)
J Child Psychol Psychiatry
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Bailey, A.1
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24
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0029966009
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Brief report: Neuropsychology of autism: a report on the state of the science
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Dawson G: Brief report: neuropsychology of autism: a report on the state of the science. J Autism Dev Disord 1996, 26:179-184. This brief report summarizes current thinking on the neuropsychological mechanisms in autism.
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J Autism Dev Disord
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Dawson, G.1
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25
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Neuropsychologic functioning in autism: Profile of a complex information processing disorder
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Minshew NJ, Goldstein G, Siegel D: Neuropsychologic functioning in autism: profile of a complex information processing disorder. J lnternatl Neuropsychol Soc 1997, 3:303-316. Puts forth a comprehensive argument for conceptualizing autism as a syndrome of multiple primary deficits.
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Minshew, N.J.1
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26
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Schizophrenia: A disconnection syndrome?
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Friston KJ, Frith C: Schizophrenia: a disconnection syndrome? Clin Neurosci 1995, 3:89-97.
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Clin Neurosci
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Friston, K.J.1
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27
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Fragile X mental retardation protein: Nucleocytoplasmic shuttling and association with somatodendritis ribosomes
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Feng Y, Gutekunst CA, Eberhart DE, Yi H, Warren ST, Hersch SM: Fragile X mental retardation protein: nucleocytoplasmic shuttling and association with somatodendritis ribosomes. J Neurosci 1997, 17:1539-1547.
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J Neurosci
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Feng, Y.1
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28
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Brief report: Neuroanatomic observations of the brain in pervasive developmental disorders
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Bauman ML: Brief report: neuroanatomic observations of the brain in pervasive developmental disorders. J Autism Dev Disord 1996, 26:199-203. The work of Bauman and Kemper, as summarized in this brief report, has been the foundation for our current understanding of the post-mortem brain in autism.
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J Autism Dev Disord
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Bauman, M.L.1
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Rodier PM, Ingram JL, Tisdale B, Nelson S, Roman J: Embryological origin for autism: developmental anomalies of the cranial nerve motor nuclei. J Comp Neurol 1996, 370:247-261.
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J Comp Neurol
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Rodier, P.M.1
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31
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Head circumference measurements in children with autism
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Davidovitch M, Patterson B, Gartside P: Head circumference measurements in children with autism. J Child Neurol 1996, 11:389-393.
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J Child Neurol
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Davidovitch, M.1
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Head circumference in autism and other pervasive developmental disorders
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Woodhouse W, Bailey A, Rutter M, Bolton P, Baird G, Le Couteur A: Head circumference in autism and other pervasive developmental disorders. J Child Psychol Psychiatry 1996, 37:665-671.
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J Child Psychol Psychiatry
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Woodhouse, W.1
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Macrocephaly in children and adults with autism
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Lainhart J, Piven J, Wzorek M, Landa R, Santangelo SL, Coon H, Folstein SE: Macrocephaly in children and adults with autism. J Am Acad Child Adolesc Psychiatry 1997, 36:282-289. Extends the work of others showing macrocephaly in autism by examining the developmental trajectory of this phenomenon.
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J am Acad Child Adolesc Psychiatry
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Lainhart, J.1
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Autism and megalencephaly
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Bailey A, Luthert P, Bolton P, LeCouteur A, Rutter M: Autism and megalencephaly. Lancet 1993, 34:1225-1226.
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Lancet
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An MRI study of brain size in autism
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Piven J, Arndt S, Bailey J, Havercamp S, Andreasen NC, Palmer P: An MRI study of brain size in autism. Am J Psychiatry 1995, 152:1145-1149.
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Am J Psychiatry
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Piven, J.1
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Brief report: Neuroimaging in autism: The state of the science 1995
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Filipek P: Brief report: neuroimaging in autism: The state of the science 1995. J Autism Dev Disord 1996, 26:211-215.
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Regional brain enlargement in autism: A magnetic resonance imaging study
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Piven J, Arndt S, Bailey J, Andreasen N: Regional brain enlargement in autism: a magnetic resonance imaging study. J Am Acad Child Adolesc Psychiatry 1996, 35:530-536. Provides evidence for regional enlargement of the brain in autism.
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(1996)
J am Acad Child Adolesc Psychiatry
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Piven, J.1
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An MRI study of autism: The cerebellum revisited
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Piven J, Saliba K, Bailey J, Arndt S: An MRI study of autism: the cerebellum revisited. Neurology 1997, 49:546-551.
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Neurology
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Piven J, O'Leary D: Neuroimaging in autism. In Child and Adolescent Psychiatry Clinics of North America. Edited by Bradley S, Peterson WB. Philadelphia: Saunders Co.; 1997:305-323. This chapter reviews the current status of neuroimaging research in autism.
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Child and Adolescent Psychiatry Clinics of North America
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Piven, J.1
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Association of tuberous sclerosis of temporal lobes with autism and atypical autism
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Bolton PF, Griffiths PD: Association of tuberous sclerosis of temporal lobes with autism and atypical autism. Lancet 1997, 349:392-395. Provides new evidence suggesting that the presence of temporal lobe tubers may be important in the pathogenesis of autism in individuals with tuberous sclerosis.
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Lancet
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Bolton, P.F.1
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Autism and tuberous sclerosis complex: Prevalence and clinical features
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Baker P, Piven J, Sato Y: Autism and tuberous sclerosis complex: prevalence and clinical features. J Autism Dev Disord 1997, in press.
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J Autism Dev Disord
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Egaas B, Courchesne E, Saitoh O: Reduced size of corpus callosum in autism. Arch Neurol 1995, 52:794-801.
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Arch Neurol
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An MRI study of the corpus callosum in autism
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Piven J, Bailey J, Ranson BJ, Arndt S: An MRI study of the corpus callosum in autism. Am J Psychiatry 1997, 154:1051-1056.
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Am J Psychiatry
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Piven, J.1
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Cross-sectional area of the posterior hippocampus in autistic patients with cerebellar and corpus callosum abnormalities
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Saitoh O, Courchesne E, Egaas B, Lincoln AJ, Schreibman L: Cross-sectional area of the posterior hippocampus in autistic patients with cerebellar and corpus callosum abnormalities. Neurology 1995, 45:317-324.
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46
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Delayed maturation of the frontal cortex in childhood autism
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Zilbovicius M, Garreau B, Samson Y, Remy P, Barthélémy C, Syrota A, Lelord G: Delayed maturation of the frontal cortex in childhood autism. Am J Psychiatry 1995, 152:248-252. This functional imaging study is unique in taking a developmental perspective on understanding brain mechanisms in autism.
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Am J Psychiatry
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Zilbovicius, M.1
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47
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Anterior cingulate gyrus volume and glucose metabolism in autistic disorder
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in press
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Haznedar MM, Buchsbaum MS, Metzger M, Solimando A, Spiegel-Cohen J, Hollander E: Anterior cingulate gyrus volume and glucose metabolism in autistic disorder. Am J Psychiatry 1997, in press. This PET study reports abnormalities that are consistent with post-mortem studies in autism that suggest abnormal development of limbic structures.
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(1997)
Am J Psychiatry
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Haznedar, M.M.1
Buchsbaum, M.S.2
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48
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Theory of mind' in the brain, evidence from a PET scan study of Asperger syndrome
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Happé F, Ehlers S, Fletcher P, Frith U, Johansson M, Gillberg C, Dolan R, Frackowiak R, Frith C: 'Theory of mind' in the brain, evidence from a PET scan study of Asperger syndrome. Neuroreport 1996, 8:197-201. Employing a novel cortical activation paradigm based on the wealth of psychological studies suggesting the importance of 'theory of mind' in autism, these investigators demonstrate focal areas of abnormality on PET scans in individuals with Asperger syndrome.
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(1996)
Neuroreport
, vol.8
, pp. 197-201
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Happé, F.1
Ehlers, S.2
Fletcher, P.3
Frith, U.4
Johansson, M.5
Gillberg, C.6
Dolan, R.7
Frackowiak, R.8
Frith, C.9
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49
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0029803880
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A double-blind, placebo-controlled study of fluvoxamine in adults with autistic disorder
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McDougle CJ, Naylor ST, Cohen DJ, Volkmar FR, Heninger GR, Price LH: A double-blind, placebo-controlled study of fluvoxamine in adults with autistic disorder. Arch Gen Psychiatry 1996, 53:1001-1008. Provides good evidence for the efficacy of selective serotonin reuptake inhibitors (SSRIs) in the treatment of abnormal ritualistic/repetitive behaviors in autism.
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(1996)
Arch Gen Psychiatry
, vol.53
, pp. 1001-1008
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McDougle, C.J.1
Naylor, S.T.2
Cohen, D.J.3
Volkmar, F.R.4
Heninger, G.R.5
Price, L.H.6
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51
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0029944752
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Brief report: Genetic, prenatal, and immunologic factors
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Smalley SL, Collins F: Brief report: genetic, prenatal, and immunologic factors. J Autism Dev Disord 1996, 20:195-198.
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(1996)
J Autism Dev Disord
, vol.20
, pp. 195-198
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Smalley, S.L.1
Collins, F.2
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