Hyper- and hypoinsulinemia in type-2 diabetes: What may be wrong in the secretory mechanism of the B-cell

Experimental and Clinical Endocrinology and Diabetes

Volumn 105, Issue SUPPL. 2, 1997, Pages 43-47

  Ammon, H P T ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN;

B LYMPHOCYTE; DESENSITIZATION; HYPERINSULINEMIA; HYPOINSULINEMIA; INSULIN RELEASE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; REVIEW;

EID: 0030777319     PISSN: 09477349     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0029-1211796     Document Type: Review

References (22)

1. Ammon HPT, Wahl MA: Islet redox ratios: their role in insulin release. In: Flatt PR, Lenzen S (eds.). Frontiers of insulin secretion and Pancreatic B-cell Research, pp. 113-122, 1994
2. Ammon HPT, Bacher M, Brändle WF, Ahmed ME, Waheed A: Sensitization of the insulin secretory mechanism after 48 h glucose infusion in rats. Diabetologia 38 (Suppl. 1): A 110, 1995
3. Ammon HPT: Wege der Nachrichtenübermittlung bei der Stimulation der Sekretion von Insulin. Diabetes und Stoffwechsel 3, Band 4: 311-320, 1995
4. Bedoya FJ, Jeanrenaud B: Evolution of insulin secretory response to glucose by perifused islets from lean (fa/fa) rats chronically infused with glucose. Diabetes 40: 7-14, 1991
5. Bolaffi JL, Bruno L, Heldt A, Grodsky GM: Characteristics of desensitization of insulin secretion in fully in vitro systems. Endocrinology 122: 1801-1809, 1988
6. Davalli AM, Pontiroli AE, Socci C, Bertuzzi F, Fattor B, Braghi S, Dicarlo V, Poza G: Human islets chronically exposed in vitro to different stimuli become unresponsive to the same stimuli given acutely - evidence supporting specific desensitization rather than beta-cell exhaustion. J Clin Endocrinol Metab 74: 790-794, 1992
7. Eizirik DL, Korbutt GS, Hellerström C: Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the beta-cell function. J Clin Invest 90: 1263-1268, 1992
8. Leahy JL, Cooper HE, Deal DA, Weir GC: Chronic hyperglycemia is associated with impaired glucose influence on insulin secretion, A study in normal rats using chronic in vivo glucose infusions. J Clin Invest 77: 908-915, 1986
9. Leahy JL, Cooper HE, Weir GC: Impaired insulin secretion associated with near normoglycemia. Diabetes 36: 459-464, 1987
10. Leahy JL: Natural history of β-cell dysfunction in NIDDM. Diabetes Care 13: 992-1010, 1990
11. Leahy JL, Weir GC: Beta-cell dysfunction in hyperglycaemic rat models: recovery of glucose-induced insulin secretion with lowering of the ambient glucose level. Diabetologia 34: 640-647, 1991
12. Marynissen G, Leclercq-Meyer V, Sener A, Malaisse WJ: Pertubation of pancreatic islet function in glucose-infused rats. Metabolism 39: 87-95, 1990
13. 2+ in impaired sensitivity to glucose of rat pancreatic islets exposed to high glucose in vitro. Diabetes 41: 1555-1561, 1992
14. + channels function in perifused rat pancreatic islets. Diabetes 39: 397-399, 1990
15. Purrello F, Buscema M, Rabuazo AM, Forte F, Vetri M, Vinci C, Caltabiano V: Potential role of glucose transport in the mechanism of glucose-induced insulin release. Diab Nutr Metab 5: 9-14, 1992
16. Sako Y, Grill VE: Coupling of R-cell desensitization by hyperglycemia to excessive stimulation and circulating insulin glucose-infused rats. Diabetes 39: 1580-1583, 1990
17. Steinke J, Patel TN, Ammon HPT: Relationship between glucose- and tolbutamide-induced insulin release and insulin content in single pancreatic rat islets. Metabolism 21: 465-470, 1972
18. Svenson C, Hellerström C: Long-term effects of a high glucose concentration in vitro on the oxidative metabolism and insulin production of isolated rat pancreatic islets. Metabolism 40: 513-518, 1991
19. 2+ in glucose-induced sensitization/desensitization of insulin secretion. Experientia 47: 1201-1208, 1991
20. Thibault C, Guettet C, Laury MC, N'Guyen JMN, Tormo MA, Bailbe D, Portha B, Penicaud L, Ktorza A: In vivo and in vitro increased pancreatic beta-cell sensitivity to glucose in normal rats submitted to a 48-h hyperglycaemic period. Diabetologia 36: 589-595, 1993
21. Timmers KI, Powell AM, Voyles NR, Solomon D, Wilkins SD, Bhathena S, Recant L: Multiple alterations in insulin responses to glucose in islets from 48-h glucose-infused nondiabetic rats. Diabetes 39: 1436-1444, 1990
22. Zawalich WS, Zawalich KC, Shulman GI, Rossetti L: Chronic in vivo hyperglycemia impairs phosphoinositide hydrolysis and insulin release in isolated perifused rat islets. Endocrinology 126: 253-260, 1990