A simple linker for the attachment of aldehydes to the solid phase. Application to solid phase synthesis by the multipin® method.

Tetrahedron Letters

Volumn 38, Issue 40, 1997, Pages 7119-7122

  Ede, Nicholas J ^a   Bray, Andrew M ^a  

^a Migenix Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE;

ARTICLE; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; METHODOLOGY; PEPTIDE SYNTHESIS; REACTION ANALYSIS; STEREOCHEMISTRY;

EID: 0030777280     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)01635-3     Document Type: Article

References (19)

1. Balkenhohl, F., Bussche-Hünnefeld, C. von dem., Lansky, A., Zechel, C., Angew.Chem.Int.Ed.Engl., 1996, 35, 2288-2337.
2. Hermkens, P.H.H., Ottenheijm, H.C.J., Rees, D., Tetrahedron, 1996, 52, 4527-4554.
3. Barlos, K., Tetrahedron Lett., 1989, 30, 3943.
4. Albericio, F., Kneib-Cordonier, N., Biancalana, S., Gera, L., Masada, R.I., Hudson, D., Barany, G., J. Org. Chem., 1990, 55, 3730-3743.
5. Murphy, A.M, Dagnino, Jr., R., Vallar, P.L., Trippe, A.J., Sherman, S.L., Lumpkin, R.H., Tamura, S.Y., and Webb, T.R., J. Am. Chem. Soc., 1992, 114, 3156-3157.
6. Fehrentz, J-A., Paris, M., Heitz, A., Velek, J., Liu, C-F., Winternitz, F., and Martinez, J., Tetrahedron Lett., 1995, 36, 7871-7874.
7. Nahm, S., Weinreb, S., Tetrahedron Lett., 1981, 22, 3518-3521.
8. Dinh, T.Q., and Armstrong, R.W., Tetrahedron Lett., 1996, 37, 1161-1164.
9. Aurell, M.J., Borx, C., Cenla, M.L., Lopis, C., Tortajada, A., and Mestres, R., J. Chem. Res. (M), 1995, 2564-2572.
10. Fotouhi, N., Galakatos, N.G., Kemp, D.S., J. Org Chem., 1989, 54, 2803-2817.
11. Tam, J.P., Lu, Y.-A., Liu, C.F., and Shao, J., Proc. Natl. Acad. Sci., 1995, 92, 12485-12489.
12. Wöhr, T., Wahl, F., Nefzi, A., Rohwedder, B., Sato, T., Sun, X., and Mutter, M., J. Am. Chem. Soc., 1996, 116, 9218-9227.
13. 4-(4-Hydroxymethyl-3-methoxyphenoxy)-butyric acid; Mergler, M., Tanner, R., Gosteli, J., Grogg, P., Tetrahedron Lett., 1988, 29, 4005-4008.
14. Synthesis was performed on Synphase-MD O-series crowns (methacrylic acid/dimethylacrylamide grafted polyethylene pins).
15. Maeji, N.J., Valerio, R.M., Bray, A.M., Campbell, R.A., Geysen, H.M., Reactive Polymers, 1994, 22, 203-212
16. Bray, A.M., Chiefari, D.S., Valerio, R.M., Maeji, N.J., Tetrahedron Lett., 1995, 36, 5081-5084.
17. Smart, S.S., Mason, T.J., Bennell, P.S., Maeji, N.J., Geysen, H.M., Int. J. Peptide Protein Res., 1996, 47, 47-55.
18. Fehrentz, J.-A., Castro, B., Synthesis, 1983, 676-678.
19. 17.