Mutation of a conserved fifth transmembrane domain lysine residue (Lys215) attenuates ligand binding in the angiotensin II type 2 receptor

Molecular Brain Research

Volumn 51, Issue 1-2, 1997, Pages 238-241

  Yee, Daniel K ^a   Kisley, Lori R ^a   Heerding, Jennifer N ^a   Fluharty, Steven J ^a  

^a Pediatric Psychology   (United States)

Author keywords

Angiotensin; AT2 receptor; Ligand binding; Mutagenesis

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN DERIVATIVE; GLUTAMINE; IODINE 125; LYSINE; MEMBRANE RECEPTOR;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; LIGAND BINDING; PRIORITY JOURNAL; RADIOASSAY; RECEPTOR AFFINITY; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANGIOTENSIN II; ANIMALS; BINDING SITES; CONSERVED SEQUENCE; COS CELLS; GLUTAMINE; KINETICS; LYSINE; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; POINT MUTATION; RECEPTOR, ANGIOTENSIN, TYPE 2; RECEPTORS, ANGIOTENSIN; RECOMBINANT PROTEINS; TRANSFECTION;

ANIMALIA;

EID: 0030776967     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(97)00244-1     Document Type: Article

References (15)

1. Bernstein K.E., Berk B.C. The biology of angiotensin receptors. Am. J. Kidney Dis. 22:1993;745-754.
2. Bumpus F.M., Catt K.J., Chiu A.T., DeGasparo M., Goodfriend T., Husain A., Peach M.J., Taylor D.G., Timmermans P.B. Nomenclature for angiotensin receptors. A report of the Nomenclature Committee of the Council for High Blood Pressure Research. Hypertension. 17:1991;720-721.
3. 8-angiotensin II on murine neuroblastoma N1E-115 cells. J. Neurochem. 52:1989;1393-1400.
4. Hein L., Barsh G.S., Pratt R.E., Dzau V.J., Kobilka B.K. Behavioral and cardiovascular effects of disrupting the angiotensin II type-2 receptor gene in mice. Nature. 377:1995;744-747.
5. 1 receptor. J. Biol. Chem. 269:1994;30953-30959.
6. Ho S.N., Hunt H.D., Horton R.M., Pullen J.K., Pease L.R. Site-directed mutagenesis by overlap extension using the polymerase chain reaction. Gene. 77:1989;51-59.
7. Ichiki T., Labosky P.A., Shiota C., Okuyama S., Imagawa Y., Fogo A., Niimura F., Ichikawa I., Hogan B.L.M., Inagami T. Effects on blood pressure and exploratory behavior of mice lacking angiotensin II type-2 receptor. Nature. 377:1995;748-750.
8. Joseph M.P., Maigret B., Bonnafous J.C., Marie J., Scheraga H.A. A computer modeling postulated mechanism for angiotensin-II receptor activation. J. Prot. Chem. 14:1995;381-398.
9. Kambayashi Y., Bardhan S., Takahashi K., Tsuzuki S., Inui H., Hamakubo T., Inagami T. Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibition. J. Biol. Chem. 268:1993;24543-24546.
10. Khosla M.C., Leese R.A., Maloy W.L., Ferreira A.T., Smeby R.R., Bumpus F.M. Synthesis of some analogs of angiotensin II as specific antagonists of the parent hormone. J. Med. Chem. 15:1972;792-795.
11. Mukoyama M., Nakajima M., Horiuchi M., Sasamura H., Pratt R.E., Dzau V.J. Expression cloning of type 2 angiotensin II receptor reveals a unique class of seven-transmembrane receptors. J. Biol. Chem. 268:1993;24539-24542.
12. Murphy T.J., Alexander R.W., Griendling K.K., Runge M.S., Bernstein K.E. Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor. Nature. 351:1991;233-236.
13. Sasaki K., Yamano Y., Bardhan S., Iwai N., Murray J.J., Hasegawa M., Matsuda Y., Inagami T. Cloning and expression of a complementary DNA encoding a bovine adrenal angiotensin II type-1 receptor. Nature. 351:1991;230-233.
14. Yamano Y., Ohyama K., Chaki S., Guo D.-F., Inagami T. Identification of amino acid residues of rat angiotensin II receptor for ligand binding by site directed mutagenesis. Biochem. Biophys. Res. Commun. 187:1992;1426-1431.
15. 1). J. Biol. Chem. 270:1995;14024-14030.