Does effect of a neuroprotective agent on volume of experimental animal cerebral infarct predict effect of the agent on clinical outcome in human stroke?

Annals of the New York Academy of Sciences

Volumn 825, Issue , 1997, Pages 281-287

  Jonas, S ^a   Tran, A Q ^c   Eisenberg, E ^c   Azam, M ^a   Viera, D ^b   Grumet, S ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NEW YORK UNIVERSITY   (United States)

^c BELLEVUE HOSPITAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GANGLIOSIDE GM1; GLUCOCORTICOID; NEUROPROTECTIVE AGENT; NIMODIPINE;

BLOOD CLOT LYSIS; BRAIN INFARCTION; CLINICAL TRIAL; CONFERENCE PAPER; HEMODILUTION; HUMAN; NONHUMAN; STROKE;

ANIMALIA;

EID: 0030776575     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1997.tb48439.x     Document Type: Conference Paper

References (34)

1. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. 1995. Tissue plasminogen activator for acute ischemic stroke. N Engl. J. Med. 333: 1581-1633.
2. The European Cooperative Acute Stroke Study. 1995. Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. JAMA 274: 1017-1025.
3. Multicentre Acute Stroke Trial-Italy (MAST-I) Group. 1996. Randomized controlled trial of streptokinase, aspirin, and combination of both in treatment of acute ischaemic stroke. Lancet 346: 1509-1514.
4. The Multicenter Acute Stroke Trial-European Study Group. 1996. Thrombolytic therapy with streptokinase in acute ischemic stroke. N. Engl. J. Med. 335: 145-150.
5. The Australian Streptokinase Trial Study Group. 1996. Streptokinase for acute ischemic stroke with relationship to time of administration. JAMA 276: 961-996.
6. Early Stroke Trial Group. 1994. Early treatment of stroke with monosialoganglioside GM-1. Stroke 25: 1552-1558.
7. 1 in acute ischemic stroke. Stroke 25: 1141-1148.
8. STRAND, T., K. ASPLUND, S. ERIKSSON, E. HÄGG, F. LITHNER & P. WESTER. 1984. A randomized controlled trial of hemodilution therapy in acute ischemic stroke. Stroke 15: 980-989.
9. Scandinavian Stroke Study Group. 1987. Multicenter trial of hemodilution in acute ischemic stroke. Stroke 18: 691-699.
10. FREI, A., C. COTTIER, P. WUNDERLICH & E. LÜDIN. 1987. Glycerol and dextran combined in therapy of acute stroke. Stroke 18: 373-379.
11. BAYER, A., M. S. PATHY & R. NEWCOMBE. 1987. Double-blind randomized trial of intravenous glycerol in acute stroke. Lancet I: 405-408.
12. GOSALINGA, H., V. EIJZENBACH, J. H. S. HEUVELMANS, E. VAN DER LAAN DE VRIES, V. M. J. MELIS, H. SCHMID-SCHÖNBEIN & P. D. BEZEMER. 1992. Custom-tailored hemodilution with albumin and crystaloids in acute ischemic stroke. Stroke 23: 181-188.
13. Italian Acute Stroke Study Group. 1987. Haemodilution in acute stroke: results of the Italian Haemodilution Trial. Lancet I:318-321.
14. MILLIKAN, C. H., F. MCDOWELL & J. D. EASTON. 1987. Stroke. Lea & Febiger. Philadelphia, PA.
15. KASTE, M., R. FOGELHOLM, T. ERILÄ, H. PALOMÄKI, K. MURROS, A. RISSANEN & S. SARNA. 1994. A randomized, double-blind, placebo-controlled trial of nimodipine in acute ischemic hemispheric stroke. Stroke 25: 1348-1353.
16. SAKURAMA, T., R. KITAMURA & M. KANEKO. 1994. Tissue-type plasminogen activator improves neurological functions in a rat model of thromboembolic stroke. Stroke 25: 451-456.
17. SEREGHY, T., K. OVERGAARD & G. BOYSEN. 1993. Neuroprotection by excitatory amino acid antagonist augments the benefit of thrombolysis in embolic stroke in rats. Stroke 24: 1702-1708.
18. CARTER, L. P., A. N. GUTHKELCH, J. OROZCO & O. TEMELTAS. 1992. Influence of tissue plasminogen activator and heparin on cerebral ischemia in a rabbit model. Stroke 23: 883-888.
19. OVERGAARD, K., T. SEREGHY, H. PEDERSEN & G. BOYSEN. 1993. Neuroprotection with NBQX and thrombolysis with rt-PA in rat embolic stroke. Neurol. Res. 15: 344-349.
20. DEL ZOPPO, G. J., B. R. COPELAND, T. A. WALTZ, J. ZYROFF, E. F. PLOW & L. A. HARKER. 1986. The beneficial effect of intracarotid urokinase on acute stroke in a baboon model. Stroke 17: 638-643.
21. 1 ganglioside treatment of focal ischemia: a dose-response and microdialysis study. J. Pharmacol. Exp. Ther. 265: 24-29.
22. BORZEIX, M. G., R. CAHN & J. CAHN. 1989. Effect of brain gangliosides on early and late consequences of a transient incomplete forebrain ischemia in the rat. Pharmacology 38: 167-176.
23. BIELENBERG, G. W. & T. BECK 1991. The effects of dizocilpine (MK-801), phencyclidine, and nimodipine on infarct size 48 h after middle cerebral artery occlusion in the rat. Brain Res. 552: 338-342.
24. MARINOV, M., H. WASSMANN & S. NATSCHEV. 1991. Effect of nimodipine in treatment of experimental focal cerebral ischemia. Neurol. Res. 13: 77-83.
25. WASSMAN, H., M. MARINOV & D. MOSKOPP. 1992. Nimodipine in experimental permanent focal cerebral ischemia. Zentralbl. Neurochir. 53: 141-147.
26. BARNETT, G. H., B. BOSE, J. R. LITTLE, S. C. JONES & M. S. FRIEL. 1986. Effects of nimodipine on acute focal cerebral ischemia. Stroke 17: 884-890.
27. RICKLES, E., M. R. GAAB & H. HEISSLER. 1993. The effect of mannitol and nimodipine treatment in a rat model of temporary focal ischemia. Zentralbl. Neurochir. 54: 3-12.
28. SAKAKI, T., S. TSUNODA & T. MORIMOTO. 1991. The influence of the calcium antagonist nimodipine and induced hypertension on the behavior of the cerebral pial arteries, the blood-brain barrier, cerebral edema, and cerebral infarction in cats with one-hour occlusion of the middle cerebral artery. Neurosurgery 28: 267-272.
29. SNAPE, M. F., H. A. BALDWIN, A. J. CROSS & A. R. GREEN. The effects of chlormethiazole and nimodipine on cortical infarct area after focal cerebral ischemia in the rat. Neuroscience 53: 837-844.
30. COLE, D. J., R. M. SCHELL, J. C. DRUMMOND & L. REYNOLDS. 1993. Focal cerebral ischemia in rats; effect of hypervolemic hemodilution with diaspirin cross-linked hemoglobin versus albumin on brain injury and edema. Anesthesiology 78: 335-342.
31. MATSUI, T., H. SINYAMA & T. ASANO. 1993. Beneficial effect of prolonged administration of albumin on ischemic cerebral edema and infarction after occlusion of middle cerebral artery in rats. Neurosurgery 33: 293-300.
32. KOÇ, R. K., H. AKDEMIR, KANDEMIR, H. PAŞAOǦLU, I. S. ÖKTEM & A. PAŞAOǦLU. 1994. The therapeutic value of naloxone and mannitol in experimental focal cerebral ischemia. Res. Exp. Med. 194: 277-285.
33. TUOR, U. I., P. D. CHUMAS & M. R. DEL BIGIO. 1995. Prevention of hypoxic-ischemic damage with dexamethasone is dependent on age and not influenced by fasting. Exp. Neurol. 132: 116-122.
34. KIM, J. S., M. CHOPP & S. C. GAUTAM. 1995. High dose methylprednisolone therapy reduces expression of JE/MCP-1 mRNA and macrophage accumulation in the ischemic rat brain. J. Neurol. Sci. 128: 28-35.