Cytotoxicity of halogenated benzenes and its relationship with logP

Toxicology in Vitro

Volumn 11, Issue 5, 1997, Pages 673-677

  Fratello, G ^a   Marchini, S ^a   Zucco, F ^b   Sapora, O ^a   Stammati, A ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b CNR   (Italy)

Author keywords

cytotoxicity; Halobenzenes; logP

Indexed keywords

BENZENE DERIVATIVE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOFLUOROMETRY; CYTOTOXICITY; DNA DAMAGE; FIBROBLAST CULTURE; LUNG FIBROBLAST; NONHUMAN; QUANTITATIVE STRUCTURE ACTIVITY RELATION; TOXICITY; TOXICITY TESTING;

ANIMALIA; CELL FUSING AGENT VIRUS; CRICETINAE; CRICETULUS GRISEUS;

EID: 0030776051     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0887-2333(97)00086-6     Document Type: Article

References (15)

1. Babich H. and Borenfreund E. (1987) Structure-activity relationship (SAR) models established in vitro with the neutral red cytotoxicity assay. Toxicology in Vitro 1, 3-9.
2. Bols N. C., Bolisica S. A., Dixon D. G. and Kaiser K. L. E. (1985) The use of fish cell cultures as an indication of contaminant toxicity to fish. Aquatic Toxicology 6, 147-155.
3. Borenfreund E. and Puerner J. A. (1984) A simple quantitative procedure using monolayer culture for cytotoxicity assay (HTD/NR90). Journal of Tissue Culture Methods 8, 7-9.
4. De Bruijn J., Busser F., Seinen W. and Hermens J. (1989) Determination of octanol/water partition coefficients for hydrophobic chemicals with the 'slow-stirring' method. Environmental Toxicology and Chemistry 8, 499-512.
5. den Besten C., Brouwer A., Rietjens I. M. C. M. and van Bladeren P. J. (1994) Biotransformation and toxicity of halogenated benzenes. Human and Experimental Toxicology 13, 866-875.
6. Dillingham E. O., Mast R. W., Bass G. E. and Autian J. (1973) Toxicity of methyl- and halogen-substituted alcohols in tissue culture relative to structure-activity models and acute toxicity in mice. Journal of Pharmaceutical Science 62, 22-30.
7. Eriksson L., Sandstroem B. E., Sjoestroem M., Tysklind M. and Wold S. (1993) Modeling the cytotoxicity of halogenated aliphatic hydrocarbons. Quantitative structure-activity relationship for the IC50 to human HeLa cells. Quantitative Structure-Activity Relationship 12, 124-131.
8. Ford D. K. and Yerganian G. (1958) Observation on the chromosomes of chinese hamster cells in tissue culture. Journal of the National Cancer Institute 21, 393-425.
9. Hamilton M. A., Russo R. C. and Thurston R. V. (1977) Trimmed Spearman-Karber method for estimating median lethal concentrations in toxicity bioassays. Environmental Science and Technology 11, 714-719.
10. Hermens J., Canton J. K., Janssen P. and de Jong R. (1984) Quantitative structure-activity relationships and toxicity studies of mixtures of chemicals with anaesthetic potency: acute lethal and sublethal toxicity to Daphnia magna. Aquatic Toxicology 5, 143-154.
11. Jansson K. and Jansson V. (1993) The toxicity of chlorophenols in V-79 hamster cells. Toxicology Letters 69, 289-294.
12. Könemann H. (1981) Quantitative structure-activity relationships in fish toxicity studies. Part 1: Relationship for 50 industrial pollutants. Toxicology 19, 209-221.
13. Saito H., Koyasu J., Shigeoka T. and Tomita I. (1994) Cytotoxicity of chlorophenols to goldfish GFS cells with the MTT and LDH assays. Toxicology in Vitro 8, 1107-1112.
14. Van Leeuwen C. J., van Der Zandt P. T. J., Aldenberg T., Verhaar H. J. M. and Hermens J. L. M. (1992) Application of QSARs, extrapolation and equilibrium partitioning in aquatic effects assessment. I. Narcotic industrial pollutants. Environmental Toxicology and Chemistry 11, 267-282.
15. Veith G. D., Call D. J. and Brooke L. T. (1983) Structure-activity relationships for the fathead minnow, Pimephales promelas: narcotic industrial chemicals. Canadian Journal of Fish and Aquatic Science 40, 713-798.