The percutaneous absorption and skin distribution of lindane in man. II. In vitro studies

Human and Experimental Toxicology

Volumn 16, Issue 11, 1997, Pages 652-657

  Dick, Ian P ^a   Blain, Peter G ^a   Williams, Faith M ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Human; In vitro; Lindane; Skin absorption; Static diffusion cell; Vehicle effect

Indexed keywords

ACETONE; ALCOHOL; LINDANE; SOLVENT;

ARTICLE; BIOLOGICAL MONITORING; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; SKIN ABSORPTION; SKIN PERMEABILITY; STRATUM CORNEUM; TIME;

EID: 0030775669     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1177/096032719701601104     Document Type: Article

References (11)

1. Scott RC et al. Further validation of an in vitro method to reduce the need for in vivo studies for measuring the absorption of chemicals through rat skin. Fundamentals of Applied Toxicology 1992; 19: 484-492.
2. Clark NWE, Scott RC, Blain PG, Williams FM. Maintenance of skin viability in skin absorption systems. In: Scott RC, Guy RH, Hadgraft J, Boddé HE (eds). Prediction of Percutaneous Penetration, vol.2 Information Press Ltd, Oxford, 1991, pp 541-547.
3. Czegledi-Janko G, Avar P. Occupational exposure to lindane: Clinical and laboratory findings. British Journal of Industrial Medicine 1970; 27: 283-286.
4. Dick IP, Blain PG, Williams FM, The percutaneous absorption and skin distribution of lindane in man. I. In vivo studies. Human and Experimental Toxicology 1997; 16: 645-651.
5. Roper CS, Howes D, Blain PG, Williams FM. Prediction of the percutaneous penetration and metabolism of dodecyl decaethoxylate in rats using in vitro models. Archives of Toxicology 1995; 69: 649-654.
6. Dick IP, Blain PG, Williams FM. The percutaneous absorption and skin distribution of Lindane in man. III. Predictions from in vitro animal studies (in preparation).
7. Maibach HI, Feldmann R. Systemic absorption of pesticides through the skin of man. In: Occupational exposure to pesticides: Report to the Federal Working Group on Pest Management from the Task Group on Occupational Exposure to Peticides, Appendix B, US Government Printing Office, Washington DC, 1975, pp 120-127.
8. Moody RP, Nadeau B, Chu I. In vitro dermal absorption of pesticide: VI. In vivo and in vitro comparison of the organochlorine insecticide DDT in rat, guinea pig, pig, human and tissue-cultured skin. Toxicology In Vitro 1994; 8: 1225-1232.
9. Hunt G, Blain PG, Williams FM. Distribution of lindane in rat and human skin following topical application in vitro. In: Scott, Guy, Hadgraft, Boddé (eds). Prediction of Percutaneous Penetration, vol.2, Information Press, London, 1991, pp 508-514.
10. Grissom RE, Brownic C, Guthrie FE. In vivo and in vitro dermal penetration of lipophilic and hydrophilic pesticides in mice. Bulletin of Environmental Contamination and Toxicology 1987; 38: 917-924.
11. Dick IP, Blain PG, Williams FM, The percutaneous absorption and skin distribution of Lindane in man. IV. The use of the flow-through cell (in preparation).