Class-switching of the IgM type anti-adenocarcinoma human antibody HB4C5 into an IgG1 type resulted in the loss of the antigen binding ability

Human Antibodies

Volumn 8, Issue 3, 1997, Pages 137-145

  Haruta, Hirotaka ^a   Tachibana, Hirofumi ^a   Mochizuki, Katsumi ^b   Hashizume, Shuichi ^b   Kusakabe, Kiyoko ^c   Shirahata, Sanetaka ^a   Murakami, Hiroki ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b 2 1 1 Shimosueyoshi   (Japan)

^c TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

Class switch; HB4C5; Human monoclonal antibody; Recombinant

Indexed keywords

CANCER ANTIBODY; HUMAN MONOCLONAL ANTIBODY; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN M; IMMUNOGLOBULIN SUBCLASS;

ADENOCARCINOMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY STRUCTURE; ANTIGEN BINDING; ARTICLE; CHO CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; HYBRIDOMA; IMMUNOBLOTTING; IMMUNOGLOBULIN CONSTANT REGION; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; XENOGRAFT;

EID: 0030775628     PISSN: 10932607     EISSN: None     Source Type: Journal    
DOI: 10.3233/hab-1997-8305     Document Type: Article

References (36)

1. Graziano RF, Tempest PR, White P, Keler T, Deo Y, Ghebremariam H, Coleman K, Pfefferkorn LC, Fanger MW, Guyre PM. Construction and characterization of a humanized anti-γ-Ig receptor type I (FcγRI) monoclonal antibody. J Immunol 1995; 155: 4996
2. HER2 antibody for human cancer therapy. Proc Natl Acad Sci USA 1992; 89: 4285
3. Caron PC, Co MS, Bull MK, Avdalovic NM, Queen C, Scheinberg DA. Biological and immunological features of humanized M195 (anti-CD33) monoclonal antibodies. Cancer Res 1992; 52: 6761
4. Chester KA, Robson L, Keep PA, Pedley RB, Boden JA, Boxer GM, Hawkins RE, Begent RHJ. Production and tumor-binding characterization of a chimeric anti-CEA Fab expressed in Escherichia coli. Int J Cancer 1994; 57: 67
5. King DJ, Adair JR, Angal S, Low DC, Proudfoot KA, Lloyd JC, Bodmer MW, Yarranton GT. Expression, purification and characterization of a mouse-human chimeric antibody and chimeric Fab' fragment. Biochem J 1992; 281: 317
6. Bulens F, Vandamme AM, Berner H, Nelles L, Lijnen RH, Collen D. Construction and characterization of a functional chimeric murine-human antibody directed against human fibrin fragment-D dimer. Eur J Biochem 1991; 195: 235
7. Knight DM, Trinh H, Le J, Siegel S, Shealy D, McDonough M, Scallon B, Moore MA, Vilcek J, Daddona P, Ghrayeb J. Construction and initial characterization of a mouse-human chimeric anti-TNF antibody. Mol Immunol 1993; 30: 1443
8. Steplewski Z, Sun LK, Shearman CW, Ghrayeb J, Daddona P, Koprowski H. Biological activity of human-mouse IgG1, IgG2, IgG3, and IgG4 chimeric monoclonal antibodies with antitumor specificity. Proc Natl Acad Sci USA 1988; 85: 4852
9. Riechmann L, Clark M, Waldmann H, Winter G. Reshaping human antibodies for therapy. Nature 1988; 332: 323
10. Komori S, Yamasaki N, Shigeta M, Isojima S, Watanabe T. Production of heavy-chain class-switch variants of human monoclonal antibody by recombinant DNA technology. Clin Exp Immunol 1988; 71: 508
11. Steplewski Z, Spira G, Blaszczyk M, Lubeck MD, Radbruch A, Iliges H, Herlyn D, Rajewsky K, Scharff M. Isolation and characterization of anti-monosialoganglioside monoclonal antibody 19-9 class-switch variants. Proc Natl Acad Sci USA 1985; 82: 8653
12. Cooper LJN, Shikhman AR, Glass DD, Kangisser D, Cunningham MW, Greenspan NS. Role of heavy chain constant domains in antibody-antigen interaction. J Immunol 1993; 150: 2231
13. Cavacini LA, Ernes CL, Power J. Desharnais FD, Duval M, Montefiori D, Posner MR. Influence of heavy chain constant regions on antigen binding and HIV-1 neutralization by a human monoclonal antibody. J Immunol 1995; 155: 3638
14. Yaoita Y, Honjo T. Deletion of immunoglobulin heavy chain genes from expressed allelic chromosome. Nature 1980; 286: 850
15. Coleclough C, Cooper D, Perry RP. Rearrangement of immunoglobulin heavy chain genes during B-lymphocyte development as revealed by studies of mouse plasmacytoma cells. Proc Natl Acad Sci USA 1980; 77: 1422
16. Co MS, Avdalovic NM, Caron PC, Avdalovic MV, Scheinberg DA, Queen C. Chimeric and humanized antibodies with specificity for the CD33 antigen. J Immunol 1992; 148: 1149
17. Yano T, Yasumoto K, Nagashima A, Hashizume S, Murakami H, Nomoto K. Immunohistological characterization of human monoclonal antibody against lung cancer. J Surg Oncol 1988; 39: 108
18. Hashizume S, Mochizuki K, Murakami H, Yano T, Yasumoto K, Nomoto K. Serodiagnosis of cancer, using porcine antigens recognized by human monoclonal antibody. HB4C5. Biotherapy 1989; 1: 109
19. Tachibana H, Seki K, Murakami H. Identification of hybrid-type carbohydrate chains on the light chain of human monoclonal antibody specific to lung adenocarcinoma. Biochim Biophys Acta 1993; 1182: 257
20. Mochizuki K, Kato M, Sato S, Hashizume S, Murakami H, Nomoto K. Characterization of a lung cancer-associated human monoclonal antibody HB4C5. Hum Antibody Hybridomas 1991; 2: 116
21. Kato M, Mochizuki K, Kuroda K, Sato S, Murakami H, Yasumoto K, Nomoto K, Hashizume S. Histon H2B as an antigen recognized by long cancer-specific human monoclonal antibody HB4C5. Hum Antibody Hybridomas 1991: 2: 94
22. Hashizume S, Kamei M, Mochizuki K, Sato S, Kuroda K, Kato M, Yasumoto K, Nakahashi H, Hirose H, Tai H, Okano H, Nomoto K, Murakami H. Serodiagnosis of cancer by using Candida cytochrome c recognized by human monoclonal antibody HB4C5. Hum Antibod Hybridomas 1991; 2: 142
23. Chomczynski P, Sacchi N. Single-step method of FNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Ann Biochem 1987; 162: 156
24. Larrick JW, Danielsson L, Brenner CA, Wallace EF, Abrahamson M, Fry KE, Borrebaeck CAK. Polymerase chain reaction using mixed primers: Cloning of human monoclonal antibody variable region genes from single hybridoma cells. Biotechnology 1989; 7: 934
25. Kusakabe K, Kanaya K, Sato S, Kato M, Mochizuki K, Hashizume S, Yasumoto K, Murakami H, Nomoto K. Accumulation enhancement of human monoclonal antibody HB4C5 to lung tumor xenografts by N-deglycosylation. J Nucl Med 1994; 35: 289
26. Fraker PJ, Speck Jr. JC. Protein and cell membrane iodination with a sparingly soluble chloramide, 1,3,4,6-tetrachloro-3α,6α-di-phenylglycoluril. Biochem Biophys Res Commun 1978; 80: 849
27. Towbin H, Staehelin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications. Proc Natl Acad Sci USA 1979; 76: 4350
28. Kato M, Mochizuki K, Hashizume S, Tachibana H, Shirahata S, Murakami H. Activity enhancement of a lung cancer-associated human monoclonal antibody HB4C5 by N-deglycosylation. Hum Antibod Hybridomas 1993; 4: 9
29. Tomlinson IM, Walter G, Marks JD, Llewelyn MB, Winter G. The repertoire of human germline VH sequences reveals about fifty groups of VH segments with different hypervariable loops. J Mol Biol 1992; 227: 776
30. Randall TD, Parkhouse RME, Corley RB. J chain synthesis and secretion of hexameric IgM is differentially regulated by lipopolysaccharide and interleukin 5. Proc Natl Acad Sci USA 1992; 89: 962
31. Niles MJ, Matsuuchi L, Koshland ME. Polymer IgM assembly and secretion in lymphoid and nonlymphoid cells lines: Evidence that J chain is required for pentamer IgM synthesis. Proc Natl Acad Sci USA 1995; 92: 2884
32. Matsuda M, Kamei M, Sugimoto N, Hashizume S. Application of anti-tetanus human monoclonal antibodies. Animal Cell Technology: Basic Applied Aspects. Proc 5th Int Meet Jap Assoc Animal Cell Technol, 1992. Dordrecht: Kluwer Academic Pub 1993; pp. 617
33. Tachibana H, Jiyoun K, Taniguchi K, Ushio Y, Teruya K, Osada K, Inoue Y, Shirahata S, Murakami H. Modified antigen-binding of human antibodies with glycosylation variations of the light chains produced in sugar-limited human hybridoma cultures. In Vitro Cell Dev Biol 1995; 32: 178
34. Co Ms, Scheinberg DA, Avdalovic NM, McGraw K, Vasquez M, Caron PC, Queen C. Genetically engineered deglycosylation of the variable domain increases the affinity of an anti-CD33 monoclonal antibody. Mol Immunol 1993; 30: 1361
35. Berek C, Berger A, Apel M. Maturation of the immune response in germinal centers. Cell 1991; 67: 1121
36. Liu YJ, Johnson GD, Gordon J, MacLennan IC. Germinal centres in T-cell-dependent antibody responses. Immunol Today 1992; 13: 17