메뉴 건너뛰기




Volumn 23, Issue 5, 1997, Pages 419-423

A possible role for thrombopoietin and its receptor c-mpl in the pathobiology of essential thrombocythemia

Author keywords

c mpl receptor; Essential thrombocythemia; Pathobiology; Thrombopoietin

Indexed keywords

ONCOPROTEIN; THROMBOPOIETIN;

EID: 0030774053     PISSN: 00946176     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-996118     Document Type: Article
Times cited : (10)

References (33)
  • 1
    • 0029911507 scopus 로고    scopus 로고
    • Clonality assays and megakaryocyte culture techniques in essential thrombocythemia
    • Yan L, N Elkassar, C Gardin, et al: Clonality assays and megakaryocyte culture techniques in essential thrombocythemia. Leukemia Lymphoma 22 (suppl 1):31-40, 1996.
    • (1996) Leukemia Lymphoma , vol.22 , Issue.1 SUPPL. , pp. 31-40
    • Yan, L.1    Elkassar, N.2    Gardin, C.3
  • 2
    • 0029035985 scopus 로고
    • Thrombopoietin: The primary regulator of platelet production
    • Kaushansky K: Thrombopoietin: The primary regulator of platelet production. Blood 86:419-431, 1995.
    • (1995) Blood , vol.86 , pp. 419-431
    • Kaushansky, K.1
  • 3
    • 0031052063 scopus 로고    scopus 로고
    • Thrombopoietin: The primary regulator of megakaryocytopoiesis and thrombopoiesis
    • De Sauvage FJ, DL Eaton: Thrombopoietin: The primary regulator of megakaryocytopoiesis and thrombopoiesis. Exp Hematol 25:1-7, 1997.
    • (1997) Exp Hematol , vol.25 , pp. 1-7
    • De Sauvage, F.J.1    Eaton, D.L.2
  • 4
    • 0029861314 scopus 로고    scopus 로고
    • Thrombopoietin: In vitro predictions, in vivo realities
    • Kaushansky K: Thrombopoietin: In vitro predictions, in vivo realities. Am J Hematol 53:188-191, 1996.
    • (1996) Am J Hematol , vol.53 , pp. 188-191
    • Kaushansky, K.1
  • 5
    • 0022624954 scopus 로고
    • A retrovirus complex inducing an acute myeloproliferative leukemia disorder in mice
    • Wendung F, P Varlet, M Charon, et al: A retrovirus complex inducing an acute myeloproliferative leukemia disorder in mice. Virology 149:242-246, 1986.
    • (1986) Virology , vol.149 , pp. 242-246
    • Wendung, F.1    Varlet, P.2    Charon, M.3
  • 6
    • 0025674093 scopus 로고
    • A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors
    • Souyri M, I Vigon, JF Penciolelli, et al: A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors. Cell 63:1137-1147, 1990.
    • (1990) Cell , vol.63 , pp. 1137-1147
    • Souyri, M.1    Vigon, I.2    Penciolelli, J.F.3
  • 7
    • 0026684707 scopus 로고
    • Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: Identification of a member of the hematopoietic growth factor receptor superfamily
    • Vigon I, JP Mornon, L Cocault, et al: Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: Identification of a member of the hematopoietic growth factor receptor superfamily. Proc Natl Acad Sci USA 89:5640-5644, 1992.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 5640-5644
    • Vigon, I.1    Mornon, J.P.2    Cocault, L.3
  • 8
    • 0028332474 scopus 로고
    • Promotion of megakaryocyte progenitor expansion and differentiation by the c-mpl ligand thrombopoietin
    • Kaushansky K, S Lok, RD Holly, et al: Promotion of megakaryocyte progenitor expansion and differentiation by the c-mpl ligand thrombopoietin. Nature 369:568-571, 1994.
    • (1994) Nature , vol.369 , pp. 568-571
    • Kaushansky, K.1    Lok, S.2    Holly, R.D.3
  • 9
    • 0028909690 scopus 로고
    • Thrombopoietin (c-mpl ligand) acts synergistically with erythropoietin, stem cell factor, and IL-11 to enhance murine megakaryocyte colony growth and increases megakaryocyte ploidy in vitro
    • Broudy VC, NL Lin, K Kaushansky: Thrombopoietin (c-mpl ligand) acts synergistically with erythropoietin, stem cell factor, and IL-11 to enhance murine megakaryocyte colony growth and increases megakaryocyte ploidy in vitro. Blood 85: 1719-1726, 1995.
    • (1995) Blood , vol.85 , pp. 1719-1726
    • Broudy, V.C.1    Lin, N.L.2    Kaushansky, K.3
  • 10
    • 0029062371 scopus 로고
    • Recombinant human megakaryocyte growth and development factor stimulates thrombocytosis in normal nonhuman primates
    • Farese AM, P Hunt, T Boone, et al: Recombinant human megakaryocyte growth and development factor stimulates thrombocytosis in normal nonhuman primates. Blood 86:54-59, 1995.
    • (1995) Blood , vol.86 , pp. 54-59
    • Farese, A.M.1    Hunt, P.2    Boone, T.3
  • 11
    • 1842325907 scopus 로고
    • Randomized, douhle-blind, placebo-controlled phase I trial of pegylated megakaryocyte growth and development factor (PEG-rHuMGDF) administered to patients with advanced cancer before and after chemotherapy
    • Abstr 1014
    • Basser R, K Clarke, R Fox, et al: Randomized, douhle-blind, placebo-controlled phase I trial of pegylated megakaryocyte growth and development factor (PEG-rHuMGDF) administered to patients with advanced cancer before and after chemotherapy. Blood 86 (suppl 10):257(Abstr 1014), 1995.
    • (1995) Blood , vol.86 , Issue.10 SUPPL. , pp. 257
    • Basser, R.1    Clarke, K.2    Fox, R.3
  • 12
  • 13
    • 0346932064 scopus 로고
    • Deficiencies in early and late stages of megakaryocytopoiesis in TPO-KO mice
    • Abstr 1007
    • De Sauvage KJ, SM Luoh, K Carver-Moore, et al: Deficiencies in early and late stages of megakaryocytopoiesis in TPO-KO mice. Blood 86 (suppl 10):255 (Abstr 1007), 1995.
    • (1995) Blood , vol.86 , Issue.10 SUPPL. , pp. 255
    • De Sauvage, K.J.1    Luoh, S.M.2    Carver-Moore, K.3
  • 14
    • 0029030356 scopus 로고
    • The reciprocal relationship of thrombopoietin (c-Mpl ligand) to changes in the platelet mass during busulfan-induced thrombocytopenia in the rabbit
    • Kuter DJ, RD Rosenberg: The reciprocal relationship of thrombopoietin (c-Mpl ligand) to changes in the platelet mass during busulfan-induced thrombocytopenia in the rabbit. Blood 85:2720-2730, 1995.
    • (1995) Blood , vol.85 , pp. 2720-2730
    • Kuter, D.J.1    Rosenberg, R.D.2
  • 15
    • 0029865443 scopus 로고    scopus 로고
    • Regulation of thrombopoietin levels by c-mpl-mediated binding to platelets
    • Fielder PJ, AL Gurney, E Stefanich, et al: Regulation of thrombopoietin levels by c-mpl-mediated binding to platelets. Blood 87:2154-2161, 1996.
    • (1996) Blood , vol.87 , pp. 2154-2161
    • Fielder, P.J.1    Gurney, A.L.2    Stefanich, E.3
  • 16
    • 7844237038 scopus 로고    scopus 로고
    • Dysregulated thrombopoietin (TPO) production induces a fatal myeloproliferative syndrome in mice
    • Abstr 255
    • Villeval JL, K Cohen-Solal, M Tulliez, et al: Dysregulated thrombopoietin (TPO) production induces a fatal myeloproliferative syndrome in mice. Exp Hematol 24:1071(Abstr 255), 1996.
    • (1996) Exp Hematol , vol.24 , pp. 1071
    • Villeval, J.L.1    Cohen-Solal, K.2    Tulliez, M.3
  • 17
    • 0029956149 scopus 로고    scopus 로고
    • A model of myelofibrosis and osteosclerosis in mice induced by overexpressing thrombopoietin (mpl ligand): Reversal of disease by bone marrow transplantation
    • Yan XO, D Lacey, D Hill, et al: A model of myelofibrosis and osteosclerosis in mice induced by overexpressing thrombopoietin (mpl ligand): Reversal of disease by bone marrow transplantation. Blood 88:402-409, 1996.
    • (1996) Blood , vol.88 , pp. 402-409
    • Yan, X.O.1    Lacey, D.2    Hill, D.3
  • 18
    • 4243337800 scopus 로고    scopus 로고
    • Blood thrombopoietin (TPO) levels in patients with agnogenic myeloid metaplasia (AMM)
    • Abstr 3575
    • Wang JC, C Chen, L Loui, et al: Blood thrombopoietin (TPO) levels in patients with agnogenic myeloid metaplasia (AMM). Blood 88(suppl 1):212(Abstr 3575), 1996.
    • (1996) Blood , vol.88 , Issue.1 SUPPL. , pp. 212
    • Wang, J.C.1    Chen, C.2    Loui, L.3
  • 19
    • 0029881744 scopus 로고    scopus 로고
    • Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction
    • Emmons RVB, DM Reid, RL Cohen, et al: Human thrombopoietin levels are high when thrombocytopenia is due to megakaryocyte deficiency and low when due to increased platelet destruction. Blood 87:4068-4071, 1996.
    • (1996) Blood , vol.87 , pp. 4068-4071
    • Emmons, R.V.B.1    Reid, D.M.2    Cohen, R.L.3
  • 20
    • 0029859326 scopus 로고    scopus 로고
    • Circulating thrombopoietin concentrations in thrombocytopenic patients, including cancer patients following chemotherapy, with or without peripheral blood progenitor cell transplantation
    • Meng YG, TG Martin, ML Peterson, et al: Circulating thrombopoietin concentrations in thrombocytopenic patients, including cancer patients following chemotherapy, with or without peripheral blood progenitor cell transplantation. Br J Haematol 95:535-541, 1996.
    • (1996) Br J Haematol , vol.95 , pp. 535-541
    • Meng, Y.G.1    Martin, T.G.2    Peterson, M.L.3
  • 21
    • 85036683953 scopus 로고    scopus 로고
    • Endogenous thrombopoietin (TPO) levels in serum of patients with aplastic anemia (AA)
    • Abstr 695
    • Schrezenmeier H, M Griesshammer, A Hornkohl, et al: Endogenous thrombopoietin (TPO) levels in serum of patients with aplastic anemia (AA). Ann Haematol 73(suppl II):174(Abstr 695), 1996.
    • (1996) Ann Haematol , vol.73 , Issue.2 SUPPL. , pp. 174
    • Schrezenmeier, H.1    Griesshammer, M.2    Hornkohl, A.3
  • 22
    • 0030472273 scopus 로고    scopus 로고
    • Serum thrombopoietin levels in patients with aplastic anaemia
    • Marsh CW, M Gibson, RL Prue, et al: Serum thrombopoietin levels in patients with aplastic anaemia. Br J Haematol 95: 605-610, 1996.
    • (1996) Br J Haematol , vol.95 , pp. 605-610
    • Marsh, C.W.1    Gibson, M.2    Prue, R.L.3
  • 23
    • 0029987273 scopus 로고    scopus 로고
    • Serum thrombopoietin and plasma glycocalicin concentrations as useful diagnostic markers in thrombocytopenic disorders
    • Kunishima S, T Tahara, T Kato, et al: Serum thrombopoietin and plasma glycocalicin concentrations as useful diagnostic markers in thrombocytopenic disorders. Eur J Haematol 57:68-71, 1996.
    • (1996) Eur J Haematol , vol.57 , pp. 68-71
    • Kunishima, S.1    Tahara, T.2    Kato, T.3
  • 24
    • 0029744304 scopus 로고    scopus 로고
    • Serum thrombopoietin level in various hematological diseases
    • Usuki K, T Tahara, S Iki, et al: Serum thrombopoietin level in various hematological diseases. Stem Cells 14:558-565, 1996.
    • (1996) Stem Cells , vol.14 , pp. 558-565
    • Usuki, K.1    Tahara, T.2    Iki, S.3
  • 25
    • 8944258119 scopus 로고    scopus 로고
    • A sensitive sandwich ELISA for measuring thrombopoietin in human serum: Serum thrombopoietin levels in healthy volunteers and in patients with haemopoietic disorders
    • Tahara T, K Usuki, H Sato, et al: A sensitive sandwich ELISA for measuring thrombopoietin in human serum: Serum thrombopoietin levels in healthy volunteers and in patients with haemopoietic disorders. Br J Haematol 93:783-788, 1996.
    • (1996) Br J Haematol , vol.93 , pp. 783-788
    • Tahara, T.1    Usuki, K.2    Sato, H.3
  • 26
    • 8044228496 scopus 로고
    • Inappropriate elevation and loss of feedback regulation of thrombopoietin in essential thrombocythaemia (ET)
    • Abstr 183
    • Taylor K, L Pitcher, J Nichol, et al: Inappropriate elevation and loss of feedback regulation of thrombopoietin in essential thrombocythaemia (ET). Blood 86(suppl 1):49(Abstr 183), 1995.
    • (1995) Blood , vol.86 , Issue.1 SUPPL. , pp. 49
    • Taylor, K.1    Pitcher, L.2    Nichol, J.3
  • 27
    • 85036682003 scopus 로고    scopus 로고
    • Elevated endogenous thrombopoietin (TPO) levels in sera of patients with essential thrombocythemia (ET): Cause or consequence of abnormal platelet production?
    • Abstr 385
    • Griesshammer M, A Hornkohl, JL Nichol, et al: Elevated endogenous thrombopoietin (TPO) levels in sera of patients with essential thrombocythemia (ET): Cause or consequence of abnormal platelet production? Ann Hematol 73(suppl II):97(Abstr 385), 1996.
    • (1996) Ann Hematol , vol.73 , Issue.2 SUPPL. , pp. 97
    • Griesshammer, M.1    Hornkohl, A.2    Nichol, J.L.3
  • 28
    • 4243337800 scopus 로고    scopus 로고
    • Serum thrombopoietin (TPO) levels in patients with essential thrombocytosis (ET) and reactive thrombocytosis (RT)
    • Abstr 3576
    • Wang JC, C Chen, J Nichol: Serum thrombopoietin (TPO) levels in patients with essential thrombocytosis (ET) and reactive thrombocytosis (RT). Blood 88(suppl 1):212(Abstr 3576), 1996.
    • (1996) Blood , vol.88 , Issue.1 SUPPL. , pp. 212
    • Wang, J.C.1    Chen, C.2    Nichol, J.3
  • 29
    • 0030064060 scopus 로고    scopus 로고
    • Proto-oncogene c-mpl is involved in spontaneous megakaryocytopoiesis in myeloproliferative disorders
    • Li Y, G Hetet, JJ Kiladjian, et al: Proto-oncogene c-mpl is involved in spontaneous megakaryocytopoiesis in myeloproliferative disorders. Br J Haematol 92:60-66, 1996.
    • (1996) Br J Haematol , vol.92 , pp. 60-66
    • Li, Y.1    Hetet, G.2    Kiladjian, J.J.3
  • 30
    • 4243228153 scopus 로고    scopus 로고
    • Hypersensitivity of polycythemia vera megakaryocytic progenitors to thrombopoietin
    • Abstr 363
    • Martin JM, YK Gandhi, WR Jackson, et al: Hypersensitivity of polycythemia vera megakaryocytic progenitors to thrombopoietin. Blood 88(suppl 1): 94(Abstr 363), 1996.
    • (1996) Blood , vol.88 , Issue.1 SUPPL. , pp. 94
    • Martin, J.M.1    Gandhi, Y.K.2    Jackson, W.R.3
  • 31
    • 4244204301 scopus 로고    scopus 로고
    • Autonomous growth of megakaryocyte progenitors in essential thrombocythemia is not due to a mutation of c-mpl
    • Abstr 379
    • Debili N, JP Le Couedic, C Ternisien, et al: Autonomous growth of megakaryocyte progenitors in essential thrombocythemia is not due to a mutation of c-mpl. Blood 88(suppl 1): 98(Abstr 379), 1996.
    • (1996) Blood , vol.88 , Issue.1 SUPPL. , pp. 98
    • Debili, N.1    Le Couedic, J.P.2    Ternisien, C.3
  • 32
    • 0009519076 scopus 로고    scopus 로고
    • Failure to show molecular evidence for involvement of thromhopoietin (TPO) and c-mpl genes in essential thrombocythemia (ET)
    • Abstr 3573
    • Taylor K, D Taylor, P Favot, et al: Failure to show molecular evidence for involvement of thromhopoietin (TPO) and c-mpl genes in essential thrombocythemia (ET). Blood 88(suppl 1): 210(Abstr 3573), 1996.
    • (1996) Blood , vol.88 , Issue.1 SUPPL. , pp. 210
    • Taylor, K.1    Taylor, D.2    Favot, P.3
  • 33
    • 0003350616 scopus 로고    scopus 로고
    • Analysis of the thrombopoietin receptor (mpl) on platelets from normal and essential thrombocythemic (ET) patients
    • Abstr 2168
    • Li J, Y Xia, DJ Kuter: Analysis of the thrombopoietin receptor (mpl) on platelets from normal and essential thrombocythemic (ET) patients. Blood 88(suppl 1):595(Abstr 2168), 1996.
    • (1996) Blood , vol.88 , Issue.1 SUPPL. , pp. 595
    • Li, J.1    Xia, Y.2    Kuter, D.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.