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A mixture of cyclic and noncyclic dimers was also isolated, which accounts for the total mass balance of the reaction
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A mixture of cyclic and noncyclic dimers was also isolated, which accounts for the total mass balance of the reaction.
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26
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1542784335
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Molecular modeling [MM2 (Allinger, N. L. J. Am. Chem. Soc. 1977, 99, 8127-8134), water set)] of compound 3 showed that the lowest energy conformation was indeed the folded one. Similar computational studies have been carried out by Abramovitch's group; see ref 11.
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note
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-4 M, MeCN). However, further studies are required before drawing any conclusion. Detailed NMR studies are in progress.
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29
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9844269483
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note
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As suggested by one of the reviewers, it would be interesting check the outcome of an alternative synthetic strategy, i.e., formation of the biaryl ether followed by macrocyclization via intramolecular alkylation of the keto ester. The cyclization results will provide a direct evidence of our hypothesis as intramolecular recognition phenomena will be absent in this case. This study will be incorporated in a future full account.
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30
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33
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9844228966
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We have been informed that Professor Nogradi has also accomplished, very recently, a total synthesis of acerogenin C
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We have been informed that Professor Nogradi has also accomplished, very recently, a total synthesis of acerogenin C.
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