In vitro metabolism of dexamethasone (DEX) in human liver and kidney: The involvement of CYP3A4 and CYP17 (17,20 LYASE) and molecular modelling studies

Biochemical Pharmacology

Volumn 54, Issue 5, 1997, Pages 605-611

  Tomlinson, E S ^a   Lewis, D F V ^b   Maggs, J L ^a   Kroemer, H K ^c   Park, B K ^a   Back, D J ^a,d  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b UNIVERSITY OF SURREY   (United Kingdom)

^c DR MARGARETE FISCHER BOSCH INSTITUTE OF CLINICAL PHARMACOLOGY   (Germany)

^d Dept of Pharmacol and Therapeutics ^*  (United Kingdom)

Author keywords

CYP17 (17,20 lyase); CYP3A4; Dexamethasone; Enzyme modelling; Metabolism

Indexed keywords

CYTOCHROME P450 ISOENZYME; DEXAMETHASONE;

ARTICLE; CONTROLLED STUDY; DRUG METABOLISM; HUMAN; HUMAN TISSUE; IN VITRO STUDY; KIDNEY; LIVER; MOLECULAR MODEL; PRIORITY JOURNAL;

BINDING SITES; CYTOCHROME P-450 ENZYME SYSTEM; CYTOSOL; DEXAMETHASONE; HUMANS; KIDNEY; LIVER; MICROSOMES; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; MODELS, MOLECULAR; PROTEIN CONFORMATION; STEROID 17-ALPHA-HYDROXYLASE;

EID: 0030773459     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(97)00166-4     Document Type: Article

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