Protein and DNA contact surfaces that mediate the selective action of the Phox1 homeodomain at the c-fos serum response element

Molecular and Cellular Biology

Volumn 17, Issue 11, 1997, Pages 6653-6662

  Simon, Kenneth J ^a,b,c,d   Grueneberg, Dorre A ^b,c   Gilman, Michael ^a,b,c  

^a STONY BROOK UNIVERSITY   (United States)

^b Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

^c ARIAD PHARMACEUTICALS INC   (United States)

^d SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HOMEODOMAIN PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; DNA BINDING; DNA DETERMINATION; GENE EXPRESSION; IMMEDIATE EARLY GENE; ONCOGENE C FOS; PRIORITY JOURNAL; PROTEIN ANALYSIS; SITE DIRECTED MUTAGENESIS;

EID: 0030773053     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.17.11.6653     Document Type: Article

References (60)

1. Ananthan, J., R. Baler, D. Morrissey, J. Zuo, Y. Lan, M. Weir, and R. Voellmy. 1993. Synergistic activation of transcription is mediated by the N-terminal domain of Drosophila fushi tarazu homeoprotein and can occur without DNA binding by the protein. Mol. Cell. Biol. 13:1599-1609.
2. Bender, A., and G. F. Sprague, Jr. 1986. Yeast peptide pheromones, a-factor and alpha-factor, activate a common response mechanism in their target cells. Cell 47:929-937.
3. Berkowitz, L. A., K. T. Riabowol, and M. Z. Gilman. 1989. Multiple sequence elements of a single functional class are required for cyclic AMP responsiveness of the mouse c-fos promoter. Mol. Cell. Biol. 9:4272-4281.
4. Bradford, A. P., K. E. Conrad, P. H. Tran, M. C. Ostrowski, and A. Gutierrez-Hartmann. 1996. GHF-1/Pit-1 functions as a cell-specific integrator of Ras signaling by targeting the Ras pathway to a composite Ets-1/GHF-1 response element. J. Biol. Chem. 271:24639-24648.
5. Bradford, M. M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248.
6. Chan, S. K., and R. S. Mann. 1993. The segment identity functions of Ultrabithorax are contained within its homeo domain and carboxy-terminal sequences. Genes Dev. 7:796-811.
7. Chen, C. Y., and R. J. Schwartz. 1996. Recruitment of the tinman homolog Nkx-2.5 by serum response factor activates cardiac α-actin gene transcription. Mol. Cell. Biol. 16:6372-6384.
8. Cleary, M., S. Stern, M. Tanaka, and W. Herr. 1993. Differential positive control by Oct-1 and Oct-2: activation of a transcriptionally silent motif through Oct-1 and VP16 corecruitment. Genes Dev. 7:72-83.
9. Connolly, M. L. 1983. Solvent-accessible surfaces of proteins and nucleic acids. Science 221:709-713.
10. Duboule, D. (ed.). 1994. Guidebook to the homeobox genes. Oxford University Press, Oxford, United Kingdom.
11. Errede, B., and G. Ammerer. 1989. STE12, a protein involved in cell-type-specific transcription and signal transduction in yeast, is part of protein-DNA complexes. Genes Dev. 3:1349-1361.
12. Fitzpatrick, V. D., A. Percival-Smith, C. J. Ingles, and H. M. Krause. 1992. Homeodomain-independent activity of the fushi tarazu polypeptide in Drosophila embryos. Nature 356:610-612.
13. Gibson, G., A. Schier, P. LeMotte and W. J. Gehring. 1990. The specificities of Sex combs reduced and Antennapedia are defined by a distinct portion of each protein that includes the homeodomain. Cell 62:1087-1103.
14. Gilman, M. Z., R. N. Wilson, and R. A. Weinberg. 1986. Multiple protein-binding sites in the 5′-flanking region regulate c-fos expression. Mol. Cell. Biol. 6:4305-4316.
15. Gorman, C. M., L. F. Moffat, and B. H. Howard. 1982. Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol. Cell. Biol. 2:1044-1051.
16. Graham, R., and M. Gilman. 1991. Distinct protein targets for signals acting at the c-fos serum response element. Science 251:189-192.
17. Grueneberg, D. A., R. W. Henry, A. Brauer, C. D. Novina, V. Cheriyath, A. Roy, and M. Gilman. A multifunctional DNA-binding protein that promotes the formation of serum response factor/homeodomain complexes: identity of TFII-I. Genes Dev., in press.
18. Grueneberg, D. A., S. Natesan, C. Alexandre, and M. Z. Gilman. 1992. Human and Drosophila homeodomain proteins that enhance the DNA-binding activity of serum response factor. Science 257:1089-1095.
19. Grueneberg, D. A., K. J. Simon, K. Brennan, and M. Gilman. 1995. Sequence specific targeting of nuclear signal transduction pathways by homeodomain proteins. Mol. Cell. Biol. 15:3318-3326.
20. Halder, G., P. Callaerts, and W. J. Gehring. 1995. Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila. Science 267:1788-1792.
21. Hayashi, S., and M. P. Scott. 1990. What determines the specificity of action of Drosophila homeodomain proteins. Cell 63:883-894.
22. Hill, C. S., R. Marais, S. John, J. Wynne, S. Dalton, and R. Treisman. 1993. Functional analysis of a growth factor-responsive transcription factor complex. Cell 73:395-406.
23. Hill, C. S., and R. Treisman. 1995. Differential activation of c-fos promoter elements by serum, lysophosphatidic acid, G proteins and polypeptide growth factors. EMBO J. 14:5037-5047.
24. Hoppler, S., and M. Bienz. 1994. Specification of a single cell type by a Drosophila homeotic gene. Cell 76:689-702.
25. Jack, T., G. L. Fox, and E. M. Meyerowitz. 1994. Arabidopsis homeotic gene APETALA3 ectopic expression: transcriptional and posttranscriptional regulation determine floral organ identity. Cell 76:703-716.
26. Kessel, M., and P. Gruss. 1990. Murine developmental control genes. Science 249:374-379.
27. Kissinger, C. R., B. S. Liu, E. Martin-Blanco, T. B. Kornberg, and C. O. Pabo. 1990. Crystal structure of an engrailed homeodomain-DNA complex at 2.8 Å resolution: a framework for understanding homeodomain-DNA interactions. Cell 63:579-590.
28. Klemm, J. D., M. A. Rould, R. Aurora, W. Herr, and C. O. Pabo. 1994. Crystal structure of the Oct-1 POU domain bound to an octamer site: DNA recognition with tethered DNA-binding modules. Cell 77:21-32.
29. Kornberg, T. B. 1993. Understanding the homeodomain. J. Biol. Chem. 268:26813-26816.
30. Kunkel, T. A. 1985. Rapid and efficient site-specific mutagenesis without phenotypic selection. Proc. Natl. Acad. Sci. USA 82:488-492.
31. Kuziora, M. A., and W. McGinnis. 1989. A homeodomain substitution changes the regulatory specificity of the Deformed protein in Drosophila embryos. Cell 59:563-571.
32. Lai, J.-S., M. A. Cleary, and W. Herr. 1992. A single amino acid exchange transfers VP16-induced positive control from the Oct-1 to the Oct-2 homeo domain. Genes Dev. 6:2058-2065.
33. Lin, L., and W. McGinnis. 1992. Mapping functional specificity in the Dfd and Ubx homeodomains. Genes Dev. 6:1071-1081.
34. Ma, H. 1994. The unfolding drama of flower development: recent results from genetic and molecular analyses. Genes Dev. 8:745-756.
35. McGinnis, W., R. L. Garber, J. Wirz, A. Kuroiwa, and W. J. Gehring. 1984. A homologous protein-coding sequence in Drosophila homeotic genes and its conservation in other metazoans. Cell 37:403-408.
36. McGinnis, W., and R. Krumlauf. 1992. Homeobox genes and axial patterning. Cell 68:283-302.
37. Mohun, T. J., A. E. Chambers, N. Towers, and M. V. Taylor. 1991. Expression of genes encoding the transcription factor SRF during early development of Xenopus laevis: identification of a CArG box-binding activity as SRF. EMBO J. 10:933-940.
38. Nakayama, N., A. Miyajima, and K. Aral. 1987. Common signal transduction system shared by STE2 and STE3 in haploid cells of Saccharomyces cerevisiae: autocrine cell-cycle arrest results from forced expression of STE2. EMBO J. 6:249-254.
39. Natesan, S., and M. Gilman. 1995. YY1 facilitates the association of serum response factor with the c-fos serum response element. Mol. Cell. Biol. 15:5975-5982.
40. Otting, G., Y. Q. Qian, M. Billeter, M. Müller, M. Affolter, W. J. Gehring, and K. Wüthrich. 1990. Protein-DNA contacts in the structure of a homeodomain-DNA complex determined by nuclear magnetic resonance spectroscopy in solution. EMBO J. 9:3085-3092.
41. Pellegrini, L., S. Tan, and T. J. Richmond. 1995. Structure of serum response factor core bound to DNA. Nature 376:490-498.
42. Qian, Y. Q., M. Billeter, G. Otting, M. Muller, W. J. Gehring, and K. Wuthrich. 1989. The structure of the Antennapedia homeodomain determined by NMR spectroscopy in solution: comparison with prokaryotic repressors. Cell 59:573-580.
43. Rubin, G. M. 1991. Signal transduction and the fate of the R7 photoreceptor in Drosophila. Trends Genet. 7:372-377.
44. Schier, A. F., and W. J. Gehring. 1993. Functional specificity of the homeodomain protein fushi tarazu: the role of DNA-binding specificity in vivo. Proc. Natl. Acad. Sci. USA 90:1450-1454.
45. Scott, M. P., and S. B. Carroll. 1987. The segmentation and homeotic gene network in early Drosophila development. Cell 51:689-698.
46. Scott, M. P., J. W. Tamkun, and G. W. Hartzell III. 1989. The structure and function of the homeodomain. Biochim. Biophys. Acta 989:25-48.
47. Scott, M. P., and A. J. Weiner. 1984. Structural relationships among genes that control development: sequence homology between the Antennapedia, Ultrabithorax, and fushi tarazu loci of Drosophila. Proc. Natl. Acad. Sci. USA 81:4115-4119.
48. Smith, D. L., and A. D. Johnson. 1992. A molecular mechanism for combinatorial control in yeast: MCM1 protein sets the spacing and orientation of the homeodomains of an α2 dimer. Cell 68:133-142.
49. Stern, S., M. Tanaka, and W. Herr. 1989. The Oct-1 homeodomain directs formation of a multiprotein-DNA complex with the HSV transactivator VP16. Nature 341:624-630.
50. Sternberg, P. W., and H. R. Horvitz. 1991. Signal transduction during C. elegans vulval induction. Trends Genet. 7:366-371.
51. Tanaka, M., and W. Herr. 1990. Differential transcriptional activation by oct-1 and oct-2: interdependent activation domains induce oct-2 phosphorylation. Cell 60:375-386.
52. Treisman, J., P. Gönczy, M. Vashishtha, E. Harris, and C. Desplan. 1989. A single amino acid can determine the DNA binding specificity of homeodomain proteins. Cell 59:553-562.
53. Treisman, R. 1990. The SRE: a growth factor responsive transcriptional regulator, p. 47-58. In N. Jones (ed.), Seminars in cancer biology transcription factors, differentiation and cancer. Saunders Scientific Publications, London, United Kingdom.
54. Treisman, R., and G. Ammerer. 1992. The SRF and MCM1 transcription factors. Curr. Opin. Genet. Dev. 2:221-226.
55. Vershon, A. K., Y. Jin, and A. D. Johnson. 1995. A homeo domain protein lacking specific side chains of helix 3 can still bind DNA and direct transcriptional repression. Genes Dev. 9:182-192.
56. Weigel, D., and E. M. Meyerowitz. 1994. The ABCs of floral homeotic genes. Cell 78:203-209.
57. Wilson, A. C., K. LaMarco, M. G. Peterson, and W. Herr. 1993. The VP16 accessory protein HCF is a family of polypeptides processed from a large precursor protein. Cell 74:115-125.
58. Wilson, D. S., B. Guenther, C. Desplan, and J. Kuriyan. 1995. High resolution crystal structure of a paired (Pax) class cooperative homeodomain dimer on DNA. Cell 82:709-719.
59. Wolberger, C., A. K. Vershon, B. Liu, A. D. Johnson, and C. O. Pabo. 1991. Crystal structure of a MAT alpha 2 homeodomain-operator complex suggests a general model for homeodomain-DNA interactions. Cell 67:517-528.
60. Zeng, W., D. J. Andrew, L. D. Mathies, M. A. Horner, and M. P. Scott. 1993. Ectopic expression and function of the Antp and Scr homeotic genes: the N terminus of the homeodomain is critical to functional specificity. Development 118:339-352.