Changes in amyloid precursor protein and apolipoprotein E immunoreactivity following ischemic brain injury in rat with long-term survival: Influence of idebenone treatment

Neuroscience Letters

Volumn 232, Issue 2, 1997, Pages 95-98

  Pluta, Ryszard ^a,b   Barcikowska, Maria ^a   Dȩbicki, Grzegorz ^a   Ryba, Mirosław ^a   Januszewski, Sławomir ^a  

^a MOSSAKOWSKI MEDICAL RESEARCH CENTRE   (Poland)

^b JÓZEF PI SUDSKI UNIVERSITY OF PHYSICAL EDUCATION IN WARSAW   (Poland)

Author keywords

Alzheimer's disease; Amyloid precursor protein; Apolipoprotein E; Cardiac arrest; Free radicals; Global cerebral ischemia; Idebenone; Rat

Indexed keywords

AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN E; FREE RADICAL; IDEBENONE;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN INJURY; BRAIN ISCHEMIA; CONTROLLED STUDY; HEART ARREST; IMMUNOREACTIVITY; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; RECEPTOR UPREGULATION; REPERFUSION INJURY; SURVIVAL TIME;

AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; APOLIPOPROTEINS E; BENZOQUINONES; BRAIN ISCHEMIA; CEREBRAL CORTEX; FEMALE; HIPPOCAMPUS; RATS; RATS, WISTAR;

EID: 0030772342     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(97)00571-5     Document Type: Article

References (22)

1. Dyrks, T., Hartmann, T., Masters, C. and Beyreuther, K., Amyloidgenicity of βA4 and βA4-bearing amyloid precursor fragments by metal-catalyzed oxidation, J. Biol. Chem., 267 (1992) 18210-18217.
2. Golde, T.E., Estus, S., Younkin, L.H., Selkoe, D.J. and Younkin, S.G., Processing of the amyloid protein precursor to potentially amyloidogenic derivatives, Science, 255 (1992) 728-730.
3. Gulyaeva, N., Stepanichev, M.Y., Onufriev, M.V., Lazareva, N.A., Zarzhetsky, Y.V., Gurvitch, A.M. and Volkov, A.V., Cardiac arrest induces decrease of nitric oxide synthase activity and increase of free radical generation in rat brain regions, Neurosci. Lett., 220 (1996) 147-150.
4. Hall, E.D. and Braughler, J.M., Central nervous system trauma and stroke. II. Physiological and pharmacological evidence for involvement of oxygen radicals and lipid peroxidation, Free Radical Biol. Med., 6 (1989) 303-313.
5. Hall, E.D., Oostveen, J.A., Dunn, E. and Carter, D.B., Increased amyloid protein precursor and apolipoprotein E immunoreactivity in the selectively vulnerable hippocampus following transient forebrain ischemia in gerbils, Exp. Neurol., 135 (1995) 17-27.
6. Harman, D., The aging process, Proc, Natl. Acad. Sci. USA, 78 (1981) 7124-7128.
7. He, Y.Y., Hsu, C.Y., Ezrin, A.M. and Miller, M.S., Polyethylene glycol-conjugated superoxide dismutase in focal cerebral ischemia-reperfusion, Am. J. Physiol., 265 (1993) H252-H256.
8. Horsburgh, K. and Nicoll, J.A.R., Selective cellular alterations in amyloid precursor protein and apolipoprotein E following transient cerebral ischemia in the rat, Alzheim. Res., 2 (1996) 37-42.
9. Ishimaru, H., Ishikawa, K., Haga, S., Shoji, M., Ohe, Y., Haga, C., Sasaki, A., Takashashi, A. and Maruyama, Y., Accumulation of apolipoprotein E and β-amyloid-like protein in a trace of the hippocampal CA1 pyramidal cell layer after ischaemic delayed neuronal death, NeuroReport, 7 (1996) 3063-3067.
10. Kida, E., Pluta, R., Lossinsky, A.S., Golabek, A.A., Choi-Miura, N.H., Wisniewski, H.M. and Mossakowski, M.J., Complete cerebral ischemia with short-term survival in rat induced by cardiac arrest. II. Extracellular and intracellular accumulation of apolipoproteins E and J in the brain, Brain Res., 674 (1995) 341-346.
11. Maury, C.P.J., Biology of disease. Molecular pathogenesis of β-amyloidosis in Alzheimer's disease and other cerebral amyloidoses, Lab. Invest., 72 (1995) 4-16.
12. Pluta, R., Lossinsky, A.S., Mossakowski, M.J., Faso, L. and Wisniewski, H.M., Reassessment of a new model of complete cerebral ischemia in rats. Method of induction of clinical death, pathophysiology and cerebrovascular pathology, Acta Neuropathol., 83 (1991) 1-11.
13. Pluta, R., Kida, E., Lossinsky, A.S., Golabek, A.A., Mossakowski, M.J. and Wisniewski, H.M., Complete cerebral ischemia with short-term survival in rats induced by cardiac arrest. I. Extracellular accumulation of Alzheimer's β-amyloid protein precursor in the brain, Brain Res., 649 (1994) 323-328.
14. Pluta, R., Lossinsky, A.S., Walski, M., Wisniewski, H.M. and Mossakowski, M.J., Platelet occlusion phenomenon after short- and long-term survival following complete cerebral ischemia in rats produced by cardiac arrest, J. Brain Res., 35 (1994) 466-471.
15. Pluta, R., Kida, E., Golabek, A.A. and Mossakowski, M.J., Possible involvement of pathomechanism(s) operating in brain ischemia, in Alzheimer's disease pathology, J. Cerebral Blood Flow Metab., 15 (Suppl. 1) (1995) S803.
16. Pluta, R., Barcikowska, M., Januszewski, S., Misicka, A. and Lipkowski, A.W., Evidence of blood-brain barrier permeability/ leakage for circulating human Alzheimer's β-amyloid-(1-42)-peptide, NeuroReport, 7 (1996) 1261-1265.
17. Pluta, R., Barcikowska, M., Kida, E., Zelman, I. and Mossakowski, M.J., Late extracellular deposits of β-amyloid precursor protein in ischaemic rat brain show different immunoreactivity to the N- and C-terminal, Alzheim. Res., 3 (1997) 51-57.
18. Selkoe, D.J., Alzheimer's disease: a central role for amyloid, J. Neuropathol. Exp. Neurol., 53 (1994) 438-447.
19. Soto, C., Golabek, A., Wisniewski, T. and Castano, E.M., Alzheimer's β-amyloid peptide is conformationally modified by apolipoprotein E in vitro, NeuroReport, 7 (1996) 721-725.
20. Tomimoto, H., Wakita, H., Akiguchi, I., Nakamura, S. and Kimura, J., Temporal profiles of accumulation of amyloid/A4 protein precursor in the gerbil after graded ischemic stress, J. Cerebral Blood Flow Metab., 14 (1994) 565-573.
21. 2+ channels: a possible involvement of free radicals, J. Neurochem., 68 (1997) 265-271.
22. Weyer, G., Erzigkeit, H., Hadler, D. and Kubicki, S., Efficacy and safety of idebenone in the long-term treatment of Alzheimer's disease: a double-blind, placebo controlled multicentre study, Hum. Psychopharmacol., 11 (1996) 53-65.